Download MendeleyDynamic remodeling of host membranes by self-organizing bacterial effectors.
Hsieh, T.S., Lopez, V.A., Black, M.H., Osinski, A., Pawlowski, K., Tomchick, D.R., Liou, J., Tagliabracci, V.S.(2021) Science 372: 935-941
- PubMed: 33927055
- DOI: https://doi.org/10.1126/science.aay8118
- Primary Citation of Related Structures:
7M7A - PubMed Abstract:
During infection, intracellular bacterial pathogens translocate a variety of effectors into host cells that modify host membrane trafficking for their benefit. We found a self-organizing system consisting of a bacterial phosphoinositide kinase and its opposing phosphatase that formed spatiotemporal patterns, including traveling waves, to remodel host cellular membranes. The Legionella effector MavQ, a phosphatidylinositol (PI) 3-kinase, was targeted to the endoplasmic reticulum (ER). MavQ and the Legionella PI 3-phosphatase SidP, even in the absence of other bacterial components, drove rapid PI 3-phosphate turnover on the ER and spontaneously formed traveling waves that spread along ER subdomains inducing vesicle and tubule budding. Thus, bacteria can exploit a self-organizing membrane-targeting mechanism to hijack host cellular structures for survival.
Organizational Affiliation:
Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
