7EVN

The cryo-EM structure of the DDX42-SF3b complex

Experimental Data Snapshot

  • Method: ELECTRON MICROSCOPY
  • Resolution: 2.60 Å
  • Aggregation State: PARTICLE 
  • Reconstruction Method: SINGLE PARTICLE 

wwPDB Validation   3D Report Full Report


This is version 1.2 of the entry. See complete history. 


Literature

Structural insights into branch site proofreading by human spliceosome

Zhang, X., Zhan, X., Bian, T., Yang, F., Li, P., Lu, Y., Xing, Z., Fan, R., Zhang, Q.C., Shi, Y.

(2024) Nat Struct Mol Biol 


Macromolecules
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Entity ID: 1
MoleculeChains Sequence LengthOrganismDetailsImage
Splicing factor 3B subunit 5A [auth B]86Homo sapiensMutation(s): 0 
Gene Names: SF3B5, SF3B10
UniProt & NIH Common Fund Data Resources
Find proteins for Q9BWJ5 (Homo sapiens)
Explore Q9BWJ5 
Go to UniProtKB:  Q9BWJ5
PHAROS:  Q9BWJ5
GTEx:  ENSG00000169976 
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UniProt GroupQ9BWJ5
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Entity ID: 2
MoleculeChains Sequence LengthOrganismDetailsImage
Splicing factor 3B subunit 1B [auth C]872Homo sapiensMutation(s): 0 
Gene Names: SF3B1, SAP155
UniProt & NIH Common Fund Data Resources
Find proteins for O75533 (Homo sapiens)
Explore O75533 
Go to UniProtKB:  O75533
PHAROS:  O75533
GTEx:  ENSG00000115524 
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UniProt GroupO75533
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Entity ID: 3
MoleculeChains Sequence LengthOrganismDetailsImage
PHD finger-like domain-containing protein 5AC [auth D]110Homo sapiensMutation(s): 0 
Gene Names: PHF5A
UniProt & NIH Common Fund Data Resources
Find proteins for Q7RTV0 (Homo sapiens)
Explore Q7RTV0 
Go to UniProtKB:  Q7RTV0
PHAROS:  Q7RTV0
GTEx:  ENSG00000100410 
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UniProt GroupQ7RTV0
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Entity ID: 4
MoleculeChains Sequence LengthOrganismDetailsImage
Splicing factor 3B subunit 3D [auth A]1,250Homo sapiensMutation(s): 0 
Gene Names: SF3B3, KIAA0017, SAP130
UniProt & NIH Common Fund Data Resources
Find proteins for Q15393 (Homo sapiens)
Explore Q15393 
Go to UniProtKB:  Q15393
PHAROS:  Q15393
GTEx:  ENSG00000189091 
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UniProt GroupQ15393
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Entity ID: 5
MoleculeChains Sequence LengthOrganismDetailsImage
ATP-dependent RNA helicase DDX42958Homo sapiensMutation(s): 0 
Gene Names: DDX42
EC: 3.6.4.13
UniProt & NIH Common Fund Data Resources
Find proteins for Q86XP3 (Homo sapiens)
Explore Q86XP3 
Go to UniProtKB:  Q86XP3
PHAROS:  Q86XP3
GTEx:  ENSG00000198231 
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UniProt GroupQ86XP3
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Experimental Data & Validation

Experimental Data

  • Method: ELECTRON MICROSCOPY
  • Resolution: 2.60 Å
  • Aggregation State: PARTICLE 
  • Reconstruction Method: SINGLE PARTICLE 

Structure Validation

View Full Validation Report



View more in-depth experimental data
Entry History & Funding Information

Deposition Data

Funding OrganizationLocationGrant Number
National Natural Science Foundation of China (NSFC)China31930059

Revision History  (Full details and data files)

  • Version 1.0: 2022-08-03
    Type: Initial release
  • Version 1.1: 2023-08-16
    Changes: Data collection, Database references
  • Version 1.2: 2024-01-17
    Changes: Database references