6ZOT

Structural and Dynamic Insights into Redundant Function of YTHDF Proteins.

(2020) J Chem Inf Model 60: 5932-5935

• PubMed: 33073985 Search on PubMed
• DOI: https://doi.org/10.1021/acs.jcim.0c01029
• Primary Citation of Related Structures:  
  6ZOT


• PubMed Abstract: 
  

  Three YTH-domain family proteins (YTHDF1, YTHDF2, and YTHDF3) recognize the N ⁶ -methyladenosine (m ⁶ A) modification of mRNA in cells. However, the redundancy of their cellular functions has been disputed. We investigate their interactions with m ⁶ A-containing RNA using X-ray crystallography and molecular dynamics (MD). The new X-ray structures and MD simulations show that the three proteins share identical interactions with the m ⁶ A-containing RNA and have similar intrinsic plasticity, thus evidencing the redundant roles of the three proteins in cellular functions.

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Organizational Affiliation: 

Department of Biochemistry, University of Zurich, CH-8057 Zurich, Switzerland.