6QBI

Solution NMR structure of Borrelia burgdorferi outer surface lipoprotein BBP28, a member of the mlp protein family.

(2020) Proteins 

• PubMed: 32949018 Search on PubMed
• DOI: https://doi.org/10.1002/prot.26011
• Primary Citation of Related Structures:  
  6QBI


• PubMed Abstract: 
  

  Lyme disease is the most widespread vector-transmitted disease in North America and Europe, caused by infection with Borrelia burgdorferi sensu lato complex spirochetes. We report the solution NMR structure of the B. burgdorferi outer surface lipoprotein BBP28, a member of the multicopy lipoprotein (mlp) family. The structure comprises a tether peptide, five α-helices and an extended C-terminal loop. The fold is similar to that of Borrelia turicatae outer surface protein BTA121, which is known to bind lipids. These results contribute to the understanding of Lyme disease pathogenesis by revealing the molecular structure of a protein from the widely found mlp family.

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Organizational Affiliation: 

Latvian Institute of Organic Synthesis, Riga, Latvia.