Download MendeleyCrystal Structure of FolP (dihydropteroate synthase) from Colstridium difficile in the presence of pteroic acid
Girardi, N.M., Thoden, J.B., Holden, H.M.To be published.
6PZ2
Crystal Structure of FolP (dihydropteroate synthase) from Colstridium difficile in the presence of pteroic acid
- PDB DOI: https://doi.org/10.2210/pdb6PZ2/pdb
- Classification: TRANSFERASE
- Organism(s): Clostridioides difficile
- Expression System: Escherichia coli
- Mutation(s): No
- Deposited: 2019-07-31 Released: 2019-11-27
- Funding Organization(s): National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 2.00 Å
- R-Value Free: 0.224
- R-Value Work: 0.188
- R-Value Observed: 0.190
This is version 1.2 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Dihydropteroate synthase | 267 | Clostridioides difficile | Mutation(s): 0 Gene Names: folP, SAMEA3374989_02220 EC: 2.5.1.15 |  | |
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 3 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| PT1 (Subject of Investigation/LOI) Query on PT1 | K [auth A] | PTEROIC ACID C14 H12 N6 O3 JOAQINSXLLMRCV-UHFFFAOYSA-N |  | ||
| NHE Query on NHE | L [auth A] | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID C8 H17 N O3 S MKWKNSIESPFAQN-UHFFFAOYSA-N |  | ||
| SO4 Query on SO4 | B [auth A] C [auth A] D [auth A] E [auth A] F [auth A] | SULFATE ION O4 S QAOWNCQODCNURD-UHFFFAOYSA-L |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 2.00 Å
- R-Value Free: 0.224
- R-Value Work: 0.188
- R-Value Observed: 0.190
- Space Group: P 63 2 2
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 156.258 | α = 90 |
| b = 156.258 | β = 90 |
| c = 84.708 | γ = 120 |
| Software Name | Purpose |
|---|---|
| REFMAC | refinement |
| PDB_EXTRACT | data extraction |
| HKL-3000 | data reduction |
| HKL-3000 | data scaling |
| PHASER | phasing |
Entry History & Funding Information
Deposition Data
- Released Date: 2019-11-27 Deposition Author(s): Girardi, N.M., Thoden, J.B., Holden, H.M.
| Funding Organization | Location | Grant Number |
|---|---|---|
| National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | United States | gm115921 |
Revision History (Full details and data files)
- Version 1.0: 2019-11-27
Type: Initial release - Version 1.1: 2020-01-01
Changes: Author supporting evidence - Version 1.2: 2023-10-11
Changes: Data collection, Database references, Refinement description
