6MSY
Anti-HIV-1 Fab Fab 2G12 + Man4 re-refinement
- PDB DOI: https://doi.org/10.2210/pdb6MSY/pdb
- Entry: 6MSY supersedes: 1ZLS
- Classification: IMMUNE SYSTEM
- Organism(s): Homo sapiens
- Expression System: Cricetulus griseus
- Mutation(s): No 
- Deposited: 2018-10-18 Released: 2018-11-21 
- Funding Organization(s): National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 2.00 Å
- R-Value Free: 0.242 
- R-Value Work: 0.206 
- R-Value Observed: 0.208 
wwPDB Validation   3D Report Full Report
Currently 6MSY does not have a validation slider image.
This is version 2.1 of the entry. See complete history. 
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
---|---|---|---|---|---|
Molecule | Chains | Sequence Length | Organism | Details | Image |
Fab 2G12, light chain | A [auth L] | 213 | Homo sapiens | Mutation(s): 0  | |
UniProt | |||||
Find proteins for P0DOX7 (Homo sapiens) Explore P0DOX7  Go to UniProtKB:  P0DOX7 | |||||
Entity Groups   | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
UniProt Group | P0DOX7 | ||||
Sequence AnnotationsExpand | |||||
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Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 2 | |||||
---|---|---|---|---|---|
Molecule | Chains | Sequence Length | Organism | Details | Image |
Fab 2g12, heavy chain | B [auth H] | 225 | Homo sapiens | Mutation(s): 0  | |
UniProt | |||||
Find proteins for P0DOX5 (Homo sapiens) Explore P0DOX5  Go to UniProtKB:  P0DOX5 | |||||
Entity Groups   | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
UniProt Group | P0DOX5 | ||||
Sequence AnnotationsExpand | |||||
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Oligosaccharides
Small Molecules
Ligands 2 Unique | |||||
---|---|---|---|---|---|
ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
ACT Query on ACT | H | ACETATE ION C2 H3 O2 QTBSBXVTEAMEQO-UHFFFAOYSA-M | |||
UNX Query on UNX | D [auth L], E [auth H], F [auth H], G [auth H] | UNKNOWN ATOM OR ION X |
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 2.00 Å
- R-Value Free: 0.242 
- R-Value Work: 0.206 
- R-Value Observed: 0.208 
- Space Group: C 2 2 2
Unit Cell:
Length ( Å ) | Angle ( ˚ ) |
---|---|
a = 144.646 | α = 90 |
b = 148.319 | β = 90 |
c = 54.604 | γ = 90 |
Software Name | Purpose |
---|---|
PHENIX | refinement |
HKL-2000 | data reduction |
SCALEPACK | data scaling |
PHASER | phasing |
Structure Validation
View Full Validation Report
Currently 6MSY does not have a validation slider image.
Entry History & Funding Information
Deposition Data
- Released Date: 2018-11-21  Deposition Author(s): Calarese, D.A., Stanfield, R.L., Wilson, I.A.
- This entry supersedes: 1ZLS
Funding Organization | Location | Grant Number |
---|---|---|
National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | United States | GM46192 |
Revision History (Full details and data files)
- Version 1.0: 2018-11-21
Type: Initial release - Version 1.1: 2020-01-01
Changes: Author supporting evidence - Version 2.0: 2020-07-29
Type: Remediation
Reason: Carbohydrate remediation
Changes: Atomic model, Data collection, Derived calculations, Structure summary - Version 2.1: 2023-10-11
Changes: Data collection, Database references, Derived calculations, Refinement description, Structure summary