Download MendeleyOptimization of 8-Hydroxyquinolines as Inhibitors of Catechol O-Methyltransferase.
Buchler, I., Akuma, D., Au, V., Carr, G., de Leon, P., DePasquale, M., Ernst, G., Huang, Y., Kimos, M., Kolobova, A., Poslusney, M., Wei, H., Swinnen, D., Montel, F., Moureau, F., Jigorel, E., Schulze, M.E.D., Wood, M., Barrow, J.C.(2018) J Med Chem 61: 9647-9665
- PubMed: 30272964
- DOI: https://doi.org/10.1021/acs.jmedchem.8b01126
- Primary Citation of Related Structures:
6GY1 - PubMed Abstract:
A series of 8-hydroxy quinolines were identified as potent inhibitors of catechol O-methyltransferase (COMT) with selectivity for the membrane-bound form of the enzyme. Small substituents at the 7-position of the quinoline were found to increase metabolic stability without sacrificing potency. Compounds with good pharmacokinetics and brain penetration were identified and demonstrated in vivo modulation of dopamine metabolites in the brain. An X-ray cocrystal structure of compound 21 in the S-COMT active site shows chelation of the active site magnesium similar to catechol-based inhibitors. These compounds should prove useful for treatment of many neurological and psychiatric conditions associated with compromised cortical dopamine signaling.
Organizational Affiliation:
Lieber Institute for Brain Development , 855 North Wolfe Street , Baltimore , Maryland 21205 , United States.
