Download MendeleyInhibition of Diverse DsbA Enzymes in Multi-DsbA Encoding Pathogens.
Totsika, M., Vagenas, D., Paxman, J.J., Wang, G., Dhouib, R., Sharma, P., Martin, J.L., Scanlon, M.J., Heras, B.(2018) Antioxid Redox Signal 29: 653-666
- PubMed: 29237285
- DOI: https://doi.org/10.1089/ars.2017.7104
- Primary Citation of Related Structures:
6BQX, 6BR4 - PubMed Abstract:
DsbA catalyzes disulfide bond formation in secreted and outer membrane proteins in bacteria. In pathogens, DsbA is a major facilitator of virulence constituting a target for antivirulence antimicrobial development. However, many pathogens encode multiple and diverse DsbA enzymes for virulence factor folding during infection. The aim of this study was to determine whether our recently identified inhibitors of Escherichia coli K-12 DsbA can inhibit the diverse DsbA enzymes found in two important human pathogens and attenuate their virulence.
Organizational Affiliation:
1 Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Queensland University of Technology , Queensland, Australia .
