Download MendeleyA doublecortin-domain protein of Toxoplasma and its orthologues bind to and modify the structure and organization of tubulin polymers.
Leung, J.M., Nagayasu, E., Hwang, Y.C., Liu, J., Pierce, P.G., Phan, I.Q., Prentice, R.A., Murray, J.M., Hu, K.(2020) BMC Mol Cell Biol 21: 8-8
- PubMed: 32111164
- DOI: https://doi.org/10.1186/s12860-020-0249-5
- Primary Citation of Related Structures:
6B4A - PubMed Abstract:
TgDCX is a doublecortin-domain protein associated with the conoid fibers, a set of strongly curved non-tubular tubulin-polymers in Toxoplasma. TgDCX deletion impairs conoid structure and parasite invasion. TgDCX contains two tubulin-binding domains: a partial P25α and the DCX/doublecortin domain. Orthologues are found in apicomplexans and their free-living relatives Chromera and Vitrella.
Organizational Affiliation:
Department of Biology, Indiana University, Bloomington, IN, 47405, USA.
