6ZM5

Human mitochondrial ribosome in complex with OXA1L, mRNA, A/A tRNA, P/P tRNA and nascent polypeptide


Experimental Data Snapshot

  • Method: ELECTRON MICROSCOPY
  • Resolution: 2.89 Å
  • Aggregation State: PARTICLE 
  • Reconstruction Method: SINGLE PARTICLE 

wwPDB Validation   3D Report Full Report


This is version 2.0 of the entry. See complete history


Literature

Mechanism of membrane-tethered mitochondrial protein synthesis.

Itoh, Y.Andrell, J.Choi, A.Richter, U.Maiti, P.Best, R.B.Barrientos, A.Battersby, B.J.Amunts, A.

(2021) Science 371: 846-849

  • DOI: https://doi.org/10.1126/science.abe0763
  • Primary Citation of Related Structures:  
    6ZM5, 6ZM6

  • PubMed Abstract: 

    Mitochondrial ribosomes (mitoribosomes) are tethered to the mitochondrial inner membrane to facilitate the cotranslational membrane insertion of the synthesized proteins. We report cryo-electron microscopy structures of human mitoribosomes with nascent polypeptide, bound to the insertase oxidase assembly 1-like (OXA1L) through three distinct contact sites. OXA1L binding is correlated with a series of conformational changes in the mitoribosomal large subunit that catalyze the delivery of newly synthesized polypeptides. The mechanism relies on the folding of mL45 inside the exit tunnel, forming two specific constriction sites that would limit helix formation of the nascent chain. A gap is formed between the exit and the membrane, making the newly synthesized proteins accessible. Our data elucidate the basis by which mitoribosomes interact with the OXA1L insertase to couple protein synthesis and membrane delivery.


  • Organizational Affiliation

    Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, 17165 Solna, Stockholm, Sweden. abarrientos@med.miami.edu brendan.battersby@helsinki.fi amunts@scilifelab.se.


Macromolecules

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Entity ID: 3
MoleculeChains Sequence LengthOrganismDetailsImage
39S ribosomal protein L2, mitochondrialC [auth D]305Homo sapiensMutation(s): 0 
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GTEx:  ENSG00000112651 
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Entity ID: 4
MoleculeChains Sequence LengthOrganismDetailsImage
39S ribosomal protein L3, mitochondrialD [auth E]348Homo sapiensMutation(s): 0 
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GTEx:  ENSG00000114686 
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Entity ID: 5
MoleculeChains Sequence LengthOrganismDetailsImage
39S ribosomal protein L4, mitochondrialE [auth F]311Homo sapiensMutation(s): 0 
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GTEx:  ENSG00000105364 
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Entity ID: 6
MoleculeChains Sequence LengthOrganismDetailsImage
39S ribosomal protein L9, mitochondrialF [auth H]267Homo sapiensMutation(s): 0 
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GTEx:  ENSG00000143436 
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Entity ID: 7
MoleculeChains Sequence LengthOrganismDetailsImage
39S ribosomal protein L10, mitochondrialG [auth I]261Homo sapiensMutation(s): 0 
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GTEx:  ENSG00000159111 
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Entity ID: 8
MoleculeChains Sequence LengthOrganismDetailsImage
39S ribosomal protein L11, mitochondrialH [auth J]192Homo sapiensMutation(s): 0 
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GTEx:  ENSG00000174547 
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Entity ID: 9
MoleculeChains Sequence LengthOrganismDetailsImage
39S ribosomal protein L13, mitochondrialI [auth K]177Homo sapiensMutation(s): 0 
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GTEx:  ENSG00000172172 
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Entity ID: 10
MoleculeChains Sequence LengthOrganismDetailsImage
39S ribosomal protein L14, mitochondrialJ [auth L]145Homo sapiensMutation(s): 0 
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GTEx:  ENSG00000180992 
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Entity ID: 11
MoleculeChains Sequence LengthOrganismDetailsImage
39S ribosomal protein L15, mitochondrialK [auth M]296Homo sapiensMutation(s): 0 
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GTEx:  ENSG00000137547 
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Entity ID: 12
MoleculeChains Sequence LengthOrganismDetailsImage
39S ribosomal protein L16, mitochondrialL [auth N]251Homo sapiensMutation(s): 0 
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GTEx:  ENSG00000166902 
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Entity ID: 13
MoleculeChains Sequence LengthOrganismDetailsImage
39S ribosomal protein L17, mitochondrialM [auth O]175Homo sapiensMutation(s): 0 
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GTEx:  ENSG00000158042 
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Entity ID: 14
MoleculeChains Sequence LengthOrganismDetailsImage
39S ribosomal protein L18, mitochondrialN [auth P]180Homo sapiensMutation(s): 0 
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GTEx:  ENSG00000112110 
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Entity ID: 15
MoleculeChains Sequence LengthOrganismDetailsImage
39S ribosomal protein L19, mitochondrialO [auth Q]292Homo sapiensMutation(s): 0 
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GTEx:  ENSG00000115364 
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Entity ID: 16
MoleculeChains Sequence LengthOrganismDetailsImage
39S ribosomal protein L20, mitochondrialP [auth R]149Homo sapiensMutation(s): 0 
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GTEx:  ENSG00000242485 
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Entity ID: 17
MoleculeChains Sequence LengthOrganismDetailsImage
39S ribosomal protein L21, mitochondrialQ [auth S]205Homo sapiensMutation(s): 0 
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GTEx:  ENSG00000197345 
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Entity ID: 18
MoleculeChains Sequence LengthOrganismDetailsImage
39S ribosomal protein L22, mitochondrialR [auth T]206Homo sapiensMutation(s): 0 
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GTEx:  ENSG00000082515 
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Entity ID: 19
MoleculeChains Sequence LengthOrganismDetailsImage
39S ribosomal protein L23, mitochondrialS [auth U]152Homo sapiensMutation(s): 0 
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GTEx:  ENSG00000214026 
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Entity ID: 20
MoleculeChains Sequence LengthOrganismDetailsImage
39S ribosomal protein L24, mitochondrialT [auth V]216Homo sapiensMutation(s): 0 
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GTEx:  ENSG00000143314 
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Entity ID: 21
MoleculeChains Sequence LengthOrganismDetailsImage
39S ribosomal protein L27, mitochondrialU [auth W]148Homo sapiensMutation(s): 0 
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GTEx:  ENSG00000108826 
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Entity ID: 22
MoleculeChains Sequence LengthOrganismDetailsImage
39S ribosomal protein L28, mitochondrialV [auth X]256Homo sapiensMutation(s): 0 
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GTEx:  ENSG00000086504 
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Entity ID: 23
MoleculeChains Sequence LengthOrganismDetailsImage
39S ribosomal protein L47, mitochondrialW [auth Y]250Homo sapiensMutation(s): 0 
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GTEx:  ENSG00000136522 
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Entity ID: 24
MoleculeChains Sequence LengthOrganismDetailsImage
39S ribosomal protein L30, mitochondrialX [auth Z]161Homo sapiensMutation(s): 0 
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GTEx:  ENSG00000185414 
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Entity ID: 25
MoleculeChains Sequence LengthOrganismDetailsImage
39S ribosomal protein L32, mitochondrialY [auth 0]188Homo sapiensMutation(s): 0 
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GTEx:  ENSG00000106591 
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Entity ID: 26
MoleculeChains Sequence LengthOrganismDetailsImage
39S ribosomal protein L33, mitochondrialZ [auth 1]65Homo sapiensMutation(s): 0 
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GTEx:  ENSG00000243147 
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Entity ID: 27
MoleculeChains Sequence LengthOrganismDetailsImage
39S ribosomal protein L34, mitochondrialAA [auth 2]92Homo sapiensMutation(s): 0 
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GTEx:  ENSG00000130312 
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Entity ID: 28
MoleculeChains Sequence LengthOrganismDetailsImage
39S ribosomal protein L35, mitochondrialBA [auth 3]188Homo sapiensMutation(s): 0 
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GTEx:  ENSG00000132313 
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Entity ID: 29
MoleculeChains Sequence LengthOrganismDetailsImage
39S ribosomal protein L36, mitochondrialCA [auth 4]103Homo sapiensMutation(s): 0 
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GTEx:  ENSG00000171421 
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Entity ID: 30
MoleculeChains Sequence LengthOrganismDetailsImage
39S ribosomal protein L37, mitochondrialDA [auth 5]423Homo sapiensMutation(s): 0 
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GTEx:  ENSG00000116221 
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Entity ID: 31
MoleculeChains Sequence LengthOrganismDetailsImage
39S ribosomal protein L38, mitochondrialEA [auth 6]380Homo sapiensMutation(s): 0 
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GTEx:  ENSG00000204316 
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Entity ID: 32
MoleculeChains Sequence LengthOrganismDetailsImage
39S ribosomal protein L39, mitochondrialFA [auth 7]338Homo sapiensMutation(s): 0 
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GTEx:  ENSG00000154719 
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Entity ID: 33
MoleculeChains Sequence LengthOrganismDetailsImage
39S ribosomal protein L40, mitochondrialGA [auth 8]206Homo sapiensMutation(s): 0 
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GTEx:  ENSG00000185608 
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Entity ID: 34
MoleculeChains Sequence LengthOrganismDetailsImage
39S ribosomal protein L41, mitochondrialHA [auth 9]137Homo sapiensMutation(s): 0 
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GTEx:  ENSG00000182154 
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Entity ID: 35
MoleculeChains Sequence LengthOrganismDetailsImage
39S ribosomal protein L42, mitochondrialIA [auth a]142Homo sapiensMutation(s): 0 
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GTEx:  ENSG00000198015 
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Entity ID: 36
MoleculeChains Sequence LengthOrganismDetailsImage
39S ribosomal protein L43, mitochondrialJA [auth b]214Homo sapiensMutation(s): 0 
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GTEx:  ENSG00000055950 
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Entity ID: 37
MoleculeChains Sequence LengthOrganismDetailsImage
39S ribosomal protein L44, mitochondrialKA [auth c]332Homo sapiensMutation(s): 0 
EC: 3.1.26
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GTEx:  ENSG00000135900 
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Entity ID: 38
MoleculeChains Sequence LengthOrganismDetailsImage
39S ribosomal protein L45, mitochondrialLA [auth d]306Homo sapiensMutation(s): 0 
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Entity ID: 39
MoleculeChains Sequence LengthOrganismDetailsImage
39S ribosomal protein L46, mitochondrialMA [auth e]279Homo sapiensMutation(s): 0 
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GTEx:  ENSG00000259494 
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Entity ID: 40
MoleculeChains Sequence LengthOrganismDetailsImage
39S ribosomal protein L48, mitochondrialNA [auth f]212Homo sapiensMutation(s): 0 
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GTEx:  ENSG00000175581 
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Entity ID: 41
MoleculeChains Sequence LengthOrganismDetailsImage
39S ribosomal protein L49, mitochondrialOA [auth g]166Homo sapiensMutation(s): 0 
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GTEx:  ENSG00000149792 
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UniProt GroupQ13405
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Entity ID: 42
MoleculeChains Sequence LengthOrganismDetailsImage
39S ribosomal protein L50, mitochondrialPA [auth h]158Homo sapiensMutation(s): 0 
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GTEx:  ENSG00000136897 
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Entity ID: 43
MoleculeChains Sequence LengthOrganismDetailsImage
39S ribosomal protein L51, mitochondrialQA [auth i]128Homo sapiensMutation(s): 0 
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GTEx:  ENSG00000111639 
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Entity ID: 44
MoleculeChains Sequence LengthOrganismDetailsImage
39S ribosomal protein L52, mitochondrialRA [auth j]123Homo sapiensMutation(s): 0 
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GTEx:  ENSG00000172590 
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Entity ID: 45
MoleculeChains Sequence LengthOrganismDetailsImage
39S ribosomal protein L53, mitochondrialSA [auth k]111Homo sapiensMutation(s): 0 
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GTEx:  ENSG00000204822 
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Entity ID: 46
MoleculeChains Sequence LengthOrganismDetailsImage
39S ribosomal protein L54, mitochondrialTA [auth l]138Homo sapiensMutation(s): 0 
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GTEx:  ENSG00000183617 
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Entity ID: 47
MoleculeChains Sequence LengthOrganismDetailsImage
39S ribosomal protein L55, mitochondrialUA [auth m]128Homo sapiensMutation(s): 0 
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GTEx:  ENSG00000162910 
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Entity ID: 48
MoleculeChains Sequence LengthOrganismDetailsImage
Ribosomal protein 63, mitochondrialVA [auth o]102Homo sapiensMutation(s): 0 
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GTEx:  ENSG00000173141 
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Entity ID: 49
MoleculeChains Sequence LengthOrganismDetailsImage
Peptidyl-tRNA hydrolase ICT1, mitochondrialWA [auth p]206Homo sapiensMutation(s): 0 
EC: 3.1.1.29
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GTEx:  ENSG00000167862 
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Entity ID: 50
MoleculeChains Sequence LengthOrganismDetailsImage
Growth arrest and DNA damage-inducible proteins-interacting protein 1XA [auth q]222Homo sapiensMutation(s): 0 
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GTEx:  ENSG00000179271 
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Entity ID: 51
MoleculeChains Sequence LengthOrganismDetailsImage
39S ribosomal protein S18a, mitochondrialYA [auth r]196Homo sapiensMutation(s): 0 
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GTEx:  ENSG00000096080 
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Entity ID: 52
MoleculeChains Sequence LengthOrganismDetailsImage
39S ribosomal protein S30, mitochondrialZA [auth s]439Homo sapiensMutation(s): 0 
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GTEx:  ENSG00000112996 
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Entity ID: 53
MoleculeChains Sequence LengthOrganismDetailsImage
39S ribosomal protein L12, mitochondrial198Homo sapiensMutation(s): 0 
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GTEx:  ENSG00000262814 
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Entity ID: 55
MoleculeChains Sequence LengthOrganismDetailsImage
28S ribosomal protein S2, mitochondrialHB [auth AB]296Homo sapiensMutation(s): 0 
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GTEx:  ENSG00000122140 
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Entity ID: 56
MoleculeChains Sequence LengthOrganismDetailsImage
28S ribosomal protein S24, mitochondrialIB [auth AC]167Homo sapiensMutation(s): 0 
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GTEx:  ENSG00000062582 
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Entity ID: 57
MoleculeChains Sequence LengthOrganismDetailsImage
28S ribosomal protein S5, mitochondrialJB [auth AD]430Homo sapiensMutation(s): 0 
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GTEx:  ENSG00000144029 
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Entity ID: 58
MoleculeChains Sequence LengthOrganismDetailsImage
28S ribosomal protein S6, mitochondrialKB [auth AE]125Homo sapiensMutation(s): 0 
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GTEx:  ENSG00000243927 
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Entity ID: 59
MoleculeChains Sequence LengthOrganismDetailsImage
28S ribosomal protein S7, mitochondrialLB [auth AF]242Homo sapiensMutation(s): 0 
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GTEx:  ENSG00000125445 
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Entity ID: 60
MoleculeChains Sequence LengthOrganismDetailsImage
28S ribosomal protein S9, mitochondrialMB [auth AG]396Homo sapiensMutation(s): 0 
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GTEx:  ENSG00000135972 
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Entity ID: 61
MoleculeChains Sequence LengthOrganismDetailsImage
28S ribosomal protein S10, mitochondrialNB [auth AH]201Homo sapiensMutation(s): 0 
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GTEx:  ENSG00000048544 
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Entity ID: 62
MoleculeChains Sequence LengthOrganismDetailsImage
28S ribosomal protein S11, mitochondrialOB [auth AI]194Homo sapiensMutation(s): 0 
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GTEx:  ENSG00000181991 
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Entity ID: 63
MoleculeChains Sequence LengthOrganismDetailsImage
28S ribosomal protein S12, mitochondrialPB [auth AJ]138Homo sapiensMutation(s): 0 
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GTEx:  ENSG00000128626 
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Entity ID: 64
MoleculeChains Sequence LengthOrganismDetailsImage
28S ribosomal protein S14, mitochondrialQB [auth AK]128Homo sapiensMutation(s): 0 
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GTEx:  ENSG00000120333 
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Entity ID: 65
MoleculeChains Sequence LengthOrganismDetailsImage
28S ribosomal protein S15, mitochondrialRB [auth AL]257Homo sapiensMutation(s): 0 
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GTEx:  ENSG00000116898 
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Entity ID: 66
MoleculeChains Sequence LengthOrganismDetailsImage
28S ribosomal protein S16, mitochondrialSB [auth AM]137Homo sapiensMutation(s): 0 
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GTEx:  ENSG00000182180 
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Entity ID: 67
MoleculeChains Sequence LengthOrganismDetailsImage
28S ribosomal protein S17, mitochondrialTB [auth AN]130Homo sapiensMutation(s): 0 
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GTEx:  ENSG00000239789 
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Entity ID: 68
MoleculeChains Sequence LengthOrganismDetailsImage
28S ribosomal protein S18b, mitochondrialUB [auth AO]258Homo sapiensMutation(s): 0 
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GTEx:  ENSG00000204568 
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Entity ID: 69
MoleculeChains Sequence LengthOrganismDetailsImage
28S ribosomal protein S18c, mitochondrialVB [auth AP]142Homo sapiensMutation(s): 0 
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GTEx:  ENSG00000163319 
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Entity ID: 70
MoleculeChains Sequence LengthOrganismDetailsImage
28S ribosomal protein S21, mitochondrialWB [auth AQ]86Homo sapiensMutation(s): 1 
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GTEx:  ENSG00000266472 
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Entity ID: 71
MoleculeChains Sequence LengthOrganismDetailsImage
28S ribosomal protein S22, mitochondrialXB [auth AR]360Homo sapiensMutation(s): 0 
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GTEx:  ENSG00000175110 
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Entity ID: 72
MoleculeChains Sequence LengthOrganismDetailsImage
28S ribosomal protein S23, mitochondrialYB [auth AS]190Homo sapiensMutation(s): 0 
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GTEx:  ENSG00000181610 
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Entity ID: 73
MoleculeChains Sequence LengthOrganismDetailsImage
28S ribosomal protein S25, mitochondrialZB [auth AT]173Homo sapiensMutation(s): 0 
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GTEx:  ENSG00000131368 
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Entity ID: 74
MoleculeChains Sequence LengthOrganismDetailsImage
28S ribosomal protein S26, mitochondrialAC [auth AU]205Homo sapiensMutation(s): 0 
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GTEx:  ENSG00000125901 
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Entity ID: 75
MoleculeChains Sequence LengthOrganismDetailsImage
28S ribosomal protein S27, mitochondrialBC [auth AV]414Homo sapiensMutation(s): 0 
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GTEx:  ENSG00000113048 
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Entity ID: 76
MoleculeChains Sequence LengthOrganismDetailsImage
28S ribosomal protein S28, mitochondrialCC [auth AW]187Homo sapiensMutation(s): 0 
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GTEx:  ENSG00000147586 
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Entity ID: 77
MoleculeChains Sequence LengthOrganismDetailsImage
28S ribosomal protein S29, mitochondrialDC [auth AX]398Homo sapiensMutation(s): 0 
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GTEx:  ENSG00000132676 
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Entity ID: 78
MoleculeChains Sequence LengthOrganismDetailsImage
28S ribosomal protein S31, mitochondrialEC [auth AY]395Homo sapiensMutation(s): 0 
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GTEx:  ENSG00000102738 
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Entity ID: 79
MoleculeChains Sequence LengthOrganismDetailsImage
28S ribosomal protein S33, mitochondrialFC [auth AZ]106Homo sapiensMutation(s): 0 
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GTEx:  ENSG00000090263 
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Entity ID: 80
MoleculeChains Sequence LengthOrganismDetailsImage
28S ribosomal protein S34, mitochondrialGC [auth A0]218Homo sapiensMutation(s): 0 
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GTEx:  ENSG00000074071 
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Entity ID: 81
MoleculeChains Sequence LengthOrganismDetailsImage
28S ribosomal protein S35, mitochondrialHC [auth A1]323Homo sapiensMutation(s): 0 
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GTEx:  ENSG00000061794 
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Entity ID: 82
MoleculeChains Sequence LengthOrganismDetailsImage
Coiled-coil-helix-coiled-coil-helix domain-containing protein 1IC [auth A2]117Homo sapiensMutation(s): 0 
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GTEx:  ENSG00000172586 
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Entity ID: 83
MoleculeChains Sequence LengthOrganismDetailsImage
Aurora kinase A-interacting proteinJC [auth A3]199Homo sapiensMutation(s): 0 
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Find proteins for Q9NWT8 (Homo sapiens)
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GTEx:  ENSG00000175756 
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Entity ID: 84
MoleculeChains Sequence LengthOrganismDetailsImage
Pentatricopeptide repeat domain-containing protein 3, mitochondrialKC [auth A4]689Homo sapiensMutation(s): 0 
UniProt & NIH Common Fund Data Resources
Find proteins for Q96EY7 (Homo sapiens)
Explore Q96EY7 
Go to UniProtKB:  Q96EY7
PHAROS:  Q96EY7
GTEx:  ENSG00000132300 
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UniProt GroupQ96EY7
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Entity ID: 85
MoleculeChains Sequence LengthOrganismDetailsImage
Mitochondrial inner membrane protein OXA1LLC [auth u]435Homo sapiensMutation(s): 0 
UniProt & NIH Common Fund Data Resources
Find proteins for Q15070 (Homo sapiens)
Explore Q15070 
Go to UniProtKB:  Q15070
PHAROS:  Q15070
GTEx:  ENSG00000155463 
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UniProt GroupQ15070
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Entity ID: 86
MoleculeChains Sequence LengthOrganismDetailsImage
Nascent polypeptideMC [auth v]32Homo sapiensMutation(s): 0 
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Entity ID: 1
MoleculeChains LengthOrganismImage
16S mitochondrial rRNA1,561Homo sapiens
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Entity ID: 2
MoleculeChains LengthOrganismImage
mitochondrial tRNAVal72Homo sapiens
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Entity ID: 54
MoleculeChains LengthOrganismImage
12S mitochondrial rRNAGB [auth AA]954Homo sapiens
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Entity ID: 87
MoleculeChains LengthOrganismImage
A-site tRNA with aminoacylationNC [auth w]68Homo sapiens
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Entity ID: 88
MoleculeChains LengthOrganismImage
P-site tRNAOC [auth x]70Homo sapiens
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Entity ID: 89
MoleculeChains LengthOrganismImage
mRNAPC [auth y]19Homo sapiens
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Small Molecules
Ligands 7 Unique
IDChains Name / Formula / InChI Key2D Diagram3D Interactions
GTP
Query on GTP

Download Ideal Coordinates CCD File 
VL [auth AX]GUANOSINE-5'-TRIPHOSPHATE
C10 H16 N5 O14 P3
XKMLYUALXHKNFT-UUOKFMHZSA-N
ATP
Query on ATP

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TL [auth AX]ADENOSINE-5'-TRIPHOSPHATE
C10 H16 N5 O13 P3
ZKHQWZAMYRWXGA-KQYNXXCUSA-N
FES
Query on FES

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EJ [auth r],
RL [auth AP],
SL [auth AT]
FE2/S2 (INORGANIC) CLUSTER
Fe2 S2
NIXDOXVAJZFRNF-UHFFFAOYSA-N
ALA
Query on ALA

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XL [auth w]ALANINE
C3 H7 N O2
QNAYBMKLOCPYGJ-REOHCLBHSA-N
ZN
Query on ZN

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AJ [auth 4],
QL [auth AO],
ZI [auth 0]
ZINC ION
Zn
PTFCDOFLOPIGGS-UHFFFAOYSA-N
K
Query on K

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AI [auth A]
BI [auth A]
CI [auth A]
CJ [auth i]
DI [auth A]
AI [auth A],
BI [auth A],
CI [auth A],
CJ [auth i],
DI [auth A],
DJ [auth o],
EI [auth A],
FI [auth A],
GI [auth A],
GL [auth AA],
HI [auth A],
HL [auth AA],
II [auth A],
IL [auth AA],
JI [auth A],
JL [auth AA],
KI [auth A],
KL [auth AA],
LI [auth A],
LL [auth AA],
MI [auth A],
ML [auth AA],
NI [auth A],
NL [auth AA],
OH [auth A],
OI [auth A],
OL [auth AA],
PH [auth A],
PI [auth A],
QH [auth A],
QI [auth A],
RH [auth A],
RI [auth A],
SH [auth A],
TH [auth A],
UH [auth A],
VH [auth A],
WH [auth A],
WI [auth M],
XH [auth A],
XI [auth N],
YH [auth A],
YI [auth P],
ZH [auth A]
POTASSIUM ION
K
NPYPAHLBTDXSSS-UHFFFAOYSA-N
MG
Query on MG

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AD [auth A]
AE [auth A]
AF [auth A]
AG [auth A]
AH [auth A]
AD [auth A],
AE [auth A],
AF [auth A],
AG [auth A],
AH [auth A],
AK [auth AA],
AL [auth AA],
BD [auth A],
BE [auth A],
BF [auth A],
BG [auth A],
BH [auth A],
BJ [auth g],
BK [auth AA],
BL [auth AA],
CD [auth A],
CE [auth A],
CF [auth A],
CG [auth A],
CH [auth A],
CK [auth AA],
CL [auth AA],
DD [auth A],
DE [auth A],
DF [auth A],
DG [auth A],
DH [auth A],
DK [auth AA],
DL [auth AA],
ED [auth A],
EE [auth A],
EF [auth A],
EG [auth A],
EH [auth A],
EK [auth AA],
EL [auth AA],
FD [auth A],
FE [auth A],
FF [auth A],
FG [auth A],
FH [auth A],
FJ [auth AA],
FK [auth AA],
FL [auth AA],
GD [auth A],
GE [auth A],
GF [auth A],
GG [auth A],
GH [auth A],
GJ [auth AA],
GK [auth AA],
HD [auth A],
HE [auth A],
HF [auth A],
HG [auth A],
HH [auth A],
HJ [auth AA],
HK [auth AA],
ID [auth A],
IE [auth A],
IF [auth A],
IG [auth A],
IH [auth A],
IJ [auth AA],
IK [auth AA],
JD [auth A],
JE [auth A],
JF [auth A],
JG [auth A],
JH [auth A],
JJ [auth AA],
JK [auth AA],
KD [auth A],
KE [auth A],
KF [auth A],
KG [auth A],
KH [auth A],
KJ [auth AA],
KK [auth AA],
LD [auth A],
LE [auth A],
LF [auth A],
LG [auth A],
LH [auth A],
LJ [auth AA],
LK [auth AA],
MD [auth A],
ME [auth A],
MF [auth A],
MG [auth A],
MH [auth A],
MJ [auth AA],
MK [auth AA],
ND [auth A],
NE [auth A],
NF [auth A],
NG [auth A],
NH [auth A],
NJ [auth AA],
NK [auth AA],
OD [auth A],
OE [auth A],
OF [auth A],
OG [auth A],
OJ [auth AA],
OK [auth AA],
PD [auth A],
PE [auth A],
PF [auth A],
PG [auth A],
PJ [auth AA],
PK [auth AA],
PL [auth AB],
QC [auth A],
QD [auth A],
QE [auth A],
QF [auth A],
QG [auth A],
QJ [auth AA],
QK [auth AA],
RC [auth A],
RD [auth A],
RE [auth A],
RF [auth A],
RG [auth A],
RJ [auth AA],
RK [auth AA],
SC [auth A],
SD [auth A],
SE [auth A],
SF [auth A],
SG [auth A],
SI [auth D],
SJ [auth AA],
SK [auth AA],
TC [auth A],
TD [auth A],
TE [auth A],
TF [auth A],
TG [auth A],
TI [auth D],
TJ [auth AA],
TK [auth AA],
UC [auth A],
UD [auth A],
UE [auth A],
UF [auth A],
UG [auth A],
UI [auth D],
UJ [auth AA],
UK [auth AA],
UL [auth AX],
VC [auth A],
VD [auth A],
VE [auth A],
VF [auth A],
VG [auth A],
VI [auth E],
VJ [auth AA],
VK [auth AA],
WC [auth A],
WD [auth A],
WE [auth A],
WF [auth A],
WG [auth A],
WJ [auth AA],
WK [auth AA],
WL [auth A3],
XC [auth A],
XD [auth A],
XE [auth A],
XF [auth A],
XG [auth A],
XJ [auth AA],
XK [auth AA],
YC [auth A],
YD [auth A],
YE [auth A],
YF [auth A],
YG [auth A],
YJ [auth AA],
YK [auth AA],
ZC [auth A],
ZD [auth A],
ZE [auth A],
ZF [auth A],
ZG [auth A],
ZJ [auth AA],
ZK [auth AA]
MAGNESIUM ION
Mg
JLVVSXFLKOJNIY-UHFFFAOYSA-N
Modified Residues  3 Unique
IDChains TypeFormula2D DiagramParent
SAC
Query on SAC
I [auth K]L-PEPTIDE LINKINGC5 H9 N O4SER
AYA
Query on AYA
S [auth U]L-PEPTIDE LINKINGC5 H9 N O3ALA
THC
Query on THC
JA [auth b]L-PEPTIDE LINKINGC6 H11 N O4THR
Experimental Data & Validation

Experimental Data

  • Method: ELECTRON MICROSCOPY
  • Resolution: 2.89 Å
  • Aggregation State: PARTICLE 
  • Reconstruction Method: SINGLE PARTICLE 
EM Software:
TaskSoftware PackageVersion
RECONSTRUCTIONRELION3.0
MODEL REFINEMENTPHENIX1.17.1-3660

Structure Validation

View Full Validation Report



Entry History & Funding Information

Deposition Data


Funding OrganizationLocationGrant Number
European Research Council (ERC)Sweden--

Revision History  (Full details and data files)

  • Version 1.0: 2021-01-13
    Type: Initial release
  • Version 1.1: 2021-03-03
    Changes: Database references
  • Version 2.0: 2023-11-15
    Changes: Atomic model, Data collection, Database references, Refinement description