Download MendeleyCrystal structure of betaine aldehyde dehydrogenase from Burkholderia pseudomallei.
Beard, D.K., Subramanian, S., Abendroth, J., Dranow, D.M., Edwards, T.E., Myler, P.J., Asojo, O.A.(2022) Acta Crystallogr F Struct Biol Commun 78: 45-51
- PubMed: 35102892
- DOI: https://doi.org/10.1107/S2053230X21013455
- Primary Citation of Related Structures:
6WSA, 6WSB - PubMed Abstract:
Burkholderia pseudomallei infection causes melioidosis, which is often fatal if untreated. There is a need to develop new and more effective treatments for melioidosis. This study reports apo and cofactor-bound crystal structures of the potential drug target betaine aldehyde dehydrogenase (BADH) from B. pseudomallei. A structural comparison identified similarities to BADH from Pseudomonas aeruginosa which is inhibited by the drug disulfiram. This preliminary analysis could facilitate drug-repurposing studies for B. pseudomallei.
Organizational Affiliation:
Department of Chemistry and Biochemistry, Hampton University, 100 William R. Harvey Way, Hampton, VA 23668, USA.
