6UCQ

Crystal structure of the Thermus thermophilus 70S ribosome recycling complex


Experimental Data Snapshot

  • Method: X-RAY DIFFRACTION
  • Resolution: 3.50 Å
  • R-Value Free: 0.294 
  • R-Value Work: 0.244 
  • R-Value Observed: 0.246 

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This is version 1.4 of the entry. See complete history


Literature

Structural basis for ribosome recycling by RRF and tRNA.

Zhou, D.Tanzawa, T.Lin, J.Gagnon, M.G.

(2020) Nat Struct Mol Biol 27: 25-32

  • DOI: https://doi.org/10.1038/s41594-019-0350-7
  • Primary Citation of Related Structures:  
    6UCQ

  • PubMed Abstract: 

    The bacterial ribosome is recycled into subunits by two conserved proteins, elongation factor G (EF-G) and the ribosome recycling factor (RRF). The molecular basis for ribosome recycling by RRF and EF-G remains unclear. Here, we report the crystal structure of a posttermination Thermus thermophilus 70S ribosome complexed with EF-G, RRF and two transfer RNAs at a resolution of 3.5 Å. The deacylated tRNA in the peptidyl (P) site moves into a previously unsuspected state of binding (peptidyl/recycling, p/R) that is analogous to that seen during initiation. The terminal end of the p/R-tRNA forms nonfavorable contacts with the 50S subunit while RRF wedges next to central inter-subunit bridges, illuminating the active roles of tRNA and RRF in dissociation of ribosomal subunits. The structure uncovers a missing snapshot of tRNA as it transits between the P and exit (E) sites, providing insights into the mechanisms of ribosome recycling and tRNA translocation.


  • Organizational Affiliation

    State Key Laboratory of Genetic Engineering, School of Life Sciences, Zhongshan Hospital, Fudan University, Shanghai, China.


Macromolecules

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Entity ID: 3
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L2C [auth 1D],
GB [auth 2D]
276Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 4
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L3D [auth 1E],
HB [auth 2E]
206Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 5
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L4E [auth 1F],
IB [auth 2F]
210Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 6
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L5F [auth 1G],
JB [auth 2G]
182Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 7
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L6G [auth 1H],
KB [auth 2H]
180Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 8
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L13H [auth 1N],
LB [auth 2N]
140Thermus thermophilus HB8Mutation(s): 0 
UniProt
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Entity ID: 9
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L14I [auth 1O],
MB [auth 2O]
122Thermus thermophilus HB8Mutation(s): 0 
UniProt
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Entity ID: 10
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L15J [auth 1P],
NB [auth 2P]
150Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 11
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L16K [auth 1Q],
OB [auth 2Q]
141Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 12
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L17L [auth 1R],
PB [auth 2R]
118Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 13
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L18M [auth 1S],
QB [auth 2S]
112Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 14
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L19N [auth 1T],
RB [auth 2T]
146Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 15
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L20O [auth 1U],
SB [auth 2U]
118Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 16
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L21P [auth 1V],
TB [auth 2V]
101Thermus thermophilus HB8Mutation(s): 0 
UniProt
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Entity ID: 17
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L22Q [auth 1W],
UB [auth 2W]
113Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 18
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L23R [auth 1X],
VB [auth 2X]
96Thermus thermophilus HB8Mutation(s): 0 
UniProt
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Entity ID: 19
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L24S [auth 1Y],
WB [auth 2Y]
110Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 20
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L25T [auth 1Z],
XB [auth 2Z]
206Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 21
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L27U [auth 10],
YB [auth 20]
85Thermus thermophilus HB8Mutation(s): 0 
UniProt
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Entity ID: 22
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L28V [auth 11],
ZB [auth 21]
98Thermus thermophilus HB8Mutation(s): 0 
UniProt
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Entity ID: 23
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L29AC [auth 22],
W [auth 12]
72Thermus thermophilus HB8Mutation(s): 0 
UniProt
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Entity ID: 24
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L30BC [auth 23],
X [auth 13]
60Thermus thermophilus HB8Mutation(s): 0 
UniProt
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Entity ID: 25
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L31CC [auth 24],
Y [auth 14]
71Thermus thermophilus HB8Mutation(s): 0 
UniProt
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Entity ID: 26
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L32DC [auth 25],
Z [auth 15]
60Thermus thermophilus HB8Mutation(s): 0 
UniProt
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Entity ID: 27
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L33AA [auth 16],
EC [auth 26]
54Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 28
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L34BA [auth 17],
FC [auth 27]
49Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 29
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L35CA [auth 18],
GC [auth 28]
65Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 30
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L36DA [auth 19],
HC [auth 29]
37Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 32
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S2FA [auth 1b],
JC [auth 2b]
256Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 33
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S3GA [auth 1c],
KC [auth 2c]
239Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 34
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S4HA [auth 1d],
LC [auth 2d]
209Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 35
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S5IA [auth 1e],
MC [auth 2e]
162Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 36
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S6JA [auth 1f],
NC [auth 2f]
101Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 37
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S7KA [auth 1g],
OC [auth 2g]
156Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 38
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S8LA [auth 1h],
PC [auth 2h]
138Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 39
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S9MA [auth 1i],
QC [auth 2i]
128Thermus thermophilus HB8Mutation(s): 0 
UniProt
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Entity ID: 40
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S10NA [auth 1j],
RC [auth 2j]
105Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 41
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S11OA [auth 1k],
SC [auth 2k]
129Thermus thermophilus HB8Mutation(s): 0 
UniProt
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Entity ID: 42
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S12PA [auth 1l],
TC [auth 2l]
132Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 43
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S13QA [auth 1m],
UC [auth 2m]
126Thermus thermophilus HB8Mutation(s): 0 
UniProt
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Entity ID: 44
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S14 type ZRA [auth 1n],
VC [auth 2n]
61Thermus thermophilus HB8Mutation(s): 0 
UniProt
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Entity ID: 45
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S15SA [auth 1o],
WC [auth 2o]
89Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 46
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S16TA [auth 1p],
XC [auth 2p]
88Thermus thermophilus HB8Mutation(s): 0 
UniProt
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Entity ID: 47
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S17UA [auth 1q],
YC [auth 2q]
105Thermus thermophilus HB8Mutation(s): 0 
UniProt
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Entity ID: 48
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S18VA [auth 1r],
ZC [auth 2r]
88Thermus thermophilus HB8Mutation(s): 0 
UniProt
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Entity ID: 49
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S19AD [auth 2s],
WA [auth 1s]
93Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 50
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S20BD [auth 2t],
XA [auth 1t]
106Thermus thermophilus HB8Mutation(s): 0 
UniProt
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Entity ID: 51
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein ThxCD [auth 2u],
YA [auth 1u]
27Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 52
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L9,Elongation factor GDD [auth 2v],
ZA [auth 1v]
758Thermus thermophilus HB8Mutation(s): 0 
Gene Names: rplITTHA0242fusAfusTTHA1695
UniProt
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Find proteins for Q5SHN5 (Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8))
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Entity ID: 53
MoleculeChains Sequence LengthOrganismDetailsImage
Ribosome-recycling factorAB [auth 1w],
ED [auth 2w]
185Thermus thermophilus HB8Mutation(s): 0 
Gene Names: frrTTHA0858
UniProt
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Entity ID: 1
MoleculeChains LengthOrganismImage
23S Ribosomal RNAA [auth 1A],
EB [auth 2A]
2,915Thermus thermophilus HB8
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Entity ID: 2
MoleculeChains LengthOrganismImage
5S Ribosomal RNAB [auth 1B],
FB [auth 2B]
121Thermus thermophilus HB8
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Entity ID: 31
MoleculeChains LengthOrganismImage
16S Ribosomal RNAEA [auth 1a],
IC [auth 2a]
1,521Thermus thermophilus HB8
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Entity ID: 54
MoleculeChains LengthOrganismImage
P-site and E-site tRNAsBB [auth 1x],
CB [auth 1y],
FD [auth 2x],
GD [auth 2y]
76Escherichia coli
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Entity ID: 55
MoleculeChains LengthOrganismImage
mRNADB [auth 1z],
HD [auth 2z]
21synthetic construct
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Small Molecules
Ligands 5 Unique
IDChains Name / Formula / InChI Key2D Diagram3D Interactions
GDP
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OJD [auth 2v],
VJB [auth 1v]
GUANOSINE-5'-DIPHOSPHATE
C10 H15 N5 O11 P2
QGWNDRXFNXRZMB-UUOKFMHZSA-N
SF4
Query on SF4

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LHD [auth 2d],
XIB [auth 1d]
IRON/SULFUR CLUSTER
Fe4 S4
LJBDFODJNLIPKO-UHFFFAOYSA-N
ZN
Query on ZN

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DVA [auth 1Y]
DWA [auth 19]
EUC [auth 24]
GUC [auth 25]
IUC [auth 26]
DVA [auth 1Y],
DWA [auth 19],
EUC [auth 24],
GUC [auth 25],
IUC [auth 26],
JJB [auth 1n],
OTC [auth 2Y],
QVA [auth 14],
TID [auth 2n],
TVA [auth 15],
VUC [auth 29],
VVA [auth 16]
ZINC ION
Zn
PTFCDOFLOPIGGS-UHFFFAOYSA-N
K
Query on K

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FKB [auth 2A]POTASSIUM ION
K
NPYPAHLBTDXSSS-UHFFFAOYSA-N
MG
Query on MG

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AAA [auth 1A]
AAB [auth 1a]
AAC [auth 2A]
AAD [auth 2a]
ABA [auth 1A]
AAA [auth 1A],
AAB [auth 1a],
AAC [auth 2A],
AAD [auth 2a],
ABA [auth 1A],
ABB [auth 1a],
ABC [auth 2A],
ABD [auth 2a],
ACA [auth 1A],
ACB [auth 1a],
ACC [auth 2A],
ACD [auth 2a],
ADA [auth 1A],
ADB [auth 1a],
ADC [auth 2A],
ADD [auth 2a],
AE [auth 1A],
AEA [auth 1A],
AEB [auth 1a],
AEC [auth 2A],
AED [auth 2a],
AF [auth 1A],
AFA [auth 1A],
AFB [auth 1a],
AFC [auth 2A],
AFD [auth 2a],
AG [auth 1A],
AGA [auth 1A],
AGB [auth 1a],
AGC [auth 2A],
AGD [auth 2a],
AH [auth 1A],
AHA [auth 1A],
AHB [auth 1a],
AHC [auth 2A],
AHD [auth 2a],
AI [auth 1A],
AIA [auth 1A],
AIB [auth 1a],
AIC [auth 2A],
AID [auth 2h],
AJ [auth 1A],
AJA [auth 1A],
AJB [auth 1e],
AJC [auth 2A],
AJD [auth 2q],
AK [auth 1A],
AKA [auth 1A],
AKB [auth 1y],
AKC [auth 2A],
AKD [auth 2y],
AL [auth 1A],
ALA [auth 1A],
ALB [auth 2A],
ALC [auth 2A],
AM [auth 1A],
AMA [auth 1A],
AMB [auth 2A],
AMC [auth 2A],
AN [auth 1A],
ANA [auth 1A],
ANB [auth 2A],
ANC [auth 2A],
AO [auth 1A],
AOA [auth 1A],
AOB [auth 2A],
AOC [auth 2A],
AP [auth 1A],
APA [auth 1A],
APB [auth 2A],
APC [auth 2A],
AQ [auth 1A],
AQA [auth 1A],
AQB [auth 2A],
AQC [auth 2A],
AR [auth 1A],
ARA [auth 1A],
ARB [auth 2A],
ARC [auth 2B],
AS [auth 1A],
ASA [auth 1A],
ASB [auth 2A],
ASC [auth 2B],
AT [auth 1A],
ATA [auth 1B],
ATB [auth 2A],
ATC [auth 2P],
AU [auth 1A],
AUA [auth 1O],
AUB [auth 2A],
AUC [auth 23],
AV [auth 1A],
AVA [auth 1W],
AVB [auth 2A],
AVC [auth 2a],
AW [auth 1A],
AWA [auth 18],
AWB [auth 2A],
AWC [auth 2a],
AX [auth 1A],
AXA [auth 1a],
AXB [auth 2A],
AXC [auth 2a],
AY [auth 1A],
AYA [auth 1a],
AYB [auth 2A],
AYC [auth 2a],
AZ [auth 1A],
AZA [auth 1a],
AZB [auth 2A],
AZC [auth 2a],
BAA [auth 1A],
BAB [auth 1a],
BAC [auth 2A],
BAD [auth 2a],
BBA [auth 1A],
BBB [auth 1a],
BBC [auth 2A],
BBD [auth 2a],
BCA [auth 1A],
BCB [auth 1a],
BCC [auth 2A],
BCD [auth 2a],
BDA [auth 1A],
BDB [auth 1a],
BDC [auth 2A],
BDD [auth 2a],
BE [auth 1A],
BEA [auth 1A],
BEB [auth 1a],
BEC [auth 2A],
BED [auth 2a],
BF [auth 1A],
BFA [auth 1A],
BFB [auth 1a],
BFC [auth 2A],
BFD [auth 2a],
BG [auth 1A],
BGA [auth 1A],
BGB [auth 1a],
BGC [auth 2A],
BGD [auth 2a],
BH [auth 1A],
BHA [auth 1A],
BHB [auth 1a],
BHC [auth 2A],
BHD [auth 2a],
BI [auth 1A],
BIA [auth 1A],
BIB [auth 1a],
BIC [auth 2A],
BID [auth 2h],
BJ [auth 1A],
BJA [auth 1A],
BJB [auth 1g],
BJC [auth 2A],
BJD [auth 2q],
BK [auth 1A],
BKA [auth 1A],
BKB [auth 1y],
BKC [auth 2A],
BKD [auth 2y],
BL [auth 1A],
BLA [auth 1A],
BLB [auth 2A],
BLC [auth 2A],
BM [auth 1A],
BMA [auth 1A],
BMB [auth 2A],
BMC [auth 2A],
BN [auth 1A],
BNA [auth 1A],
BNB [auth 2A],
BNC [auth 2A],
BO [auth 1A],
BOA [auth 1A],
BOB [auth 2A],
BOC [auth 2A],
BP [auth 1A],
BPA [auth 1A],
BPB [auth 2A],
BPC [auth 2A],
BQ [auth 1A],
BQA [auth 1A],
BQB [auth 2A],
BQC [auth 2A],
BR [auth 1A],
BRA [auth 1A],
BRB [auth 2A],
BRC [auth 2B],
BS [auth 1A],
BSA [auth 1A],
BSB [auth 2A],
BSC [auth 2B],
BT [auth 1A],
BTA [auth 1B],
BTB [auth 2A],
BTC [auth 2Q],
BU [auth 1A],
BUA [auth 1O],
BUB [auth 2A],
BUC [auth 23],
BV [auth 1A],
BVA [auth 1W],
BVB [auth 2A],
BVC [auth 2a],
BW [auth 1A],
BWA [auth 18],
BWB [auth 2A],
BWC [auth 2a],
BX [auth 1A],
BXA [auth 1a],
BXB [auth 2A],
BXC [auth 2a],
BY [auth 1A],
BYA [auth 1a],
BYB [auth 2A],
BYC [auth 2a],
BZ [auth 1A],
BZA [auth 1a],
BZB [auth 2A],
BZC [auth 2a],
CAA [auth 1A],
CAB [auth 1a],
CAC [auth 2A],
CAD [auth 2a],
CBA [auth 1A],
CBB [auth 1a],
CBC [auth 2A],
CBD [auth 2a],
CCA [auth 1A],
CCB [auth 1a],
CCC [auth 2A],
CCD [auth 2a],
CDA [auth 1A],
CDB [auth 1a],
CDC [auth 2A],
CDD [auth 2a],
CE [auth 1A],
CEA [auth 1A],
CEB [auth 1a],
CEC [auth 2A],
CED [auth 2a],
CF [auth 1A],
CFA [auth 1A],
CFB [auth 1a],
CFC [auth 2A],
CFD [auth 2a],
CG [auth 1A],
CGA [auth 1A],
CGB [auth 1a],
CGC [auth 2A],
CGD [auth 2a],
CH [auth 1A],
CHA [auth 1A],
CHB [auth 1a],
CHC [auth 2A],
CHD [auth 2a],
CI [auth 1A],
CIA [auth 1A],
CIB [auth 1a],
CIC [auth 2A],
CID [auth 2h],
CJ [auth 1A],
CJA [auth 1A],
CJB [auth 1g],
CJC [auth 2A],
CJD [auth 2r],
CK [auth 1A],
CKA [auth 1A],
CKB [auth 1y],
CKC [auth 2A],
CKD [auth 2y],
CL [auth 1A],
CLA [auth 1A],
CLB [auth 2A],
CLC [auth 2A],
CM [auth 1A],
CMA [auth 1A],
CMB [auth 2A],
CMC [auth 2A],
CN [auth 1A],
CNA [auth 1A],
CNB [auth 2A],
CNC [auth 2A],
CO [auth 1A],
COA [auth 1A],
COB [auth 2A],
COC [auth 2A],
CP [auth 1A],
CPA [auth 1A],
CPB [auth 2A],
CPC [auth 2A],
CQ [auth 1A],
CQA [auth 1A],
CQB [auth 2A],
CQC [auth 2A],
CR [auth 1A],
CRA [auth 1A],
CRB [auth 2A],
CRC [auth 2B],
CS [auth 1A],
CSA [auth 1A],
CSB [auth 2A],
CSC [auth 2B],
CT [auth 1A],
CTA [auth 1B],
CTB [auth 2A],
CTC [auth 2Q],
CU [auth 1A],
CUA [auth 1O],
CUB [auth 2A],
CUC [auth 23],
CV [auth 1A],
CVA [auth 1Y],
CVB [auth 2A],
CVC [auth 2a],
CW [auth 1A],
CWA [auth 19],
CWB [auth 2A],
CWC [auth 2a],
CX [auth 1A],
CXA [auth 1a],
CXB [auth 2A],
CXC [auth 2a],
CY [auth 1A],
CYA [auth 1a],
CYB [auth 2A],
CYC [auth 2a],
CZ [auth 1A],
CZA [auth 1a],
CZB [auth 2A],
CZC [auth 2a],
DAA [auth 1A],
DAB [auth 1a],
DAC [auth 2A],
DAD [auth 2a],
DBA [auth 1A],
DBB [auth 1a],
DBC [auth 2A],
DBD [auth 2a],
DCA [auth 1A],
DCB [auth 1a],
DCC [auth 2A],
DCD [auth 2a],
DDA [auth 1A],
DDB [auth 1a],
DDC [auth 2A],
DDD [auth 2a],
DE [auth 1A],
DEA [auth 1A],
DEB [auth 1a],
DEC [auth 2A],
DED [auth 2a],
DF [auth 1A],
DFA [auth 1A],
DFB [auth 1a],
DFC [auth 2A],
DFD [auth 2a],
DG [auth 1A],
DGA [auth 1A],
DGB [auth 1a],
DGC [auth 2A],
DGD [auth 2a],
DH [auth 1A],
DHA [auth 1A],
DHB [auth 1a],
DHC [auth 2A],
DHD [auth 2a],
DI [auth 1A],
DIA [auth 1A],
DIB [auth 1a],
DIC [auth 2A],
DID [auth 2h],
DJ [auth 1A],
DJA [auth 1A],
DJB [auth 1i],
DJC [auth 2A],
DJD [auth 2r],
DK [auth 1A],
DKA [auth 1A],
DKB [auth 1y],
DKC [auth 2A],
DKD [auth 2y],
DL [auth 1A],
DLA [auth 1A],
DLB [auth 2A],
DLC [auth 2A],
DM [auth 1A],
DMA [auth 1A],
DMB [auth 2A],
DMC [auth 2A],
DN [auth 1A],
DNA [auth 1A],
DNB [auth 2A],
DNC [auth 2A],
DO [auth 1A],
DOA [auth 1A],
DOB [auth 2A],
DOC [auth 2A],
DP [auth 1A],
DPA [auth 1A],
DPB [auth 2A],
DPC [auth 2A],
DQ [auth 1A],
DQA [auth 1A],
DQB [auth 2A],
DQC [auth 2A],
DR [auth 1A],
DRA [auth 1A],
DRB [auth 2A],
DRC [auth 2B],
DS [auth 1A],
DSA [auth 1A],
DSB [auth 2A],
DSC [auth 2B],
DT [auth 1A],
DTA [auth 1B],
DTB [auth 2A],
DTC [auth 2Q],
DU [auth 1A],
DUA [auth 1O],
DUB [auth 2A],
DUC [auth 24],
DV [auth 1A],
DVB [auth 2A],
DVC [auth 2a],
DW [auth 1A],
DWB [auth 2A],
DWC [auth 2a],
DX [auth 1A],
DXA [auth 1a],
DXB [auth 2A],
DXC [auth 2a],
DY [auth 1A],
DYA [auth 1a],
DYB [auth 2A],
DYC [auth 2a],
DZ [auth 1A],
DZA [auth 1a],
DZB [auth 2A],
DZC [auth 2a],
EAA [auth 1A],
EAB [auth 1a],
EAC [auth 2A],
EAD [auth 2a],
EBA [auth 1A],
EBB [auth 1a],
EBC [auth 2A],
EBD [auth 2a],
ECA [auth 1A],
ECB [auth 1a],
ECC [auth 2A],
ECD [auth 2a],
EDA [auth 1A],
EDB [auth 1a],
EDC [auth 2A],
EDD [auth 2a],
EE [auth 1A],
EEA [auth 1A],
EEB [auth 1a],
EEC [auth 2A],
EED [auth 2a],
EF [auth 1A],
EFA [auth 1A],
EFB [auth 1a],
EFC [auth 2A],
EFD [auth 2a],
EG [auth 1A],
EGA [auth 1A],
EGB [auth 1a],
EGC [auth 2A],
EGD [auth 2a],
EH [auth 1A],
EHA [auth 1A],
EHB [auth 1a],
EHC [auth 2A],
EHD [auth 2a],
EI [auth 1A],
EIA [auth 1A],
EIB [auth 1a],
EIC [auth 2A],
EID [auth 2i],
EJ [auth 1A],
EJA [auth 1A],
EJB [auth 1l],
EJC [auth 2A],
EJD [auth 2s],
EK [auth 1A],
EKA [auth 1A],
EKB [auth 1z],
EKC [auth 2A],
EKD [auth 2y],
EL [auth 1A],
ELA [auth 1A],
ELB [auth 2A],
ELC [auth 2A],
EM [auth 1A],
EMA [auth 1A],
EMB [auth 2A],
EMC [auth 2A],
EN [auth 1A],
ENA [auth 1A],
ENB [auth 2A],
ENC [auth 2A],
EO [auth 1A],
EOA [auth 1A],
EOB [auth 2A],
EOC [auth 2A],
EP [auth 1A],
EPA [auth 1A],
EPB [auth 2A],
EPC [auth 2A],
EQ [auth 1A],
EQA [auth 1A],
EQB [auth 2A],
EQC [auth 2A],
ER [auth 1A],
ERA [auth 1A],
ERB [auth 2A],
ERC [auth 2B],
ES [auth 1A],
ESA [auth 1A],
ESB [auth 2A],
ESC [auth 2B],
ET [auth 1A],
ETA [auth 1B],
ETB [auth 2A],
ETC [auth 2Q],
EU [auth 1A],
EUA [auth 1P],
EUB [auth 2A],
EV [auth 1A],
EVA [auth 1Z],
EVB [auth 2A],
EVC [auth 2a],
EW [auth 1A],
EWA [auth 1a],
EWB [auth 2A],
EWC [auth 2a],
EX [auth 1A],
EXA [auth 1a],
EXB [auth 2A],
EXC [auth 2a],
EY [auth 1A],
EYA [auth 1a],
EYB [auth 2A],
EYC [auth 2a],
EZ [auth 1A],
EZA [auth 1a],
EZB [auth 2A],
EZC [auth 2a],
FAA [auth 1A],
FAB [auth 1a],
FAC [auth 2A],
FAD [auth 2a],
FBA [auth 1A],
FBB [auth 1a],
FBC [auth 2A],
FBD [auth 2a],
FCA [auth 1A],
FCB [auth 1a],
FCC [auth 2A],
FCD [auth 2a],
FDA [auth 1A],
FDB [auth 1a],
FDC [auth 2A],
FDD [auth 2a],
FE [auth 1A],
FEA [auth 1A],
FEB [auth 1a],
FEC [auth 2A],
FED [auth 2a],
FF [auth 1A],
FFA [auth 1A],
FFB [auth 1a],
FFC [auth 2A],
FFD [auth 2a],
FG [auth 1A],
FGA [auth 1A],
FGB [auth 1a],
FGC [auth 2A],
FGD [auth 2a],
FH [auth 1A],
FHA [auth 1A],
FHB [auth 1a],
FHC [auth 2A],
FHD [auth 2b],
FI [auth 1A],
FIA [auth 1A],
FIB [auth 1a],
FIC [auth 2A],
FID [auth 2i],
FJ [auth 1A],
FJA [auth 1A],
FJB [auth 1m],
FJC [auth 2A],
FJD [auth 2s],
FK [auth 1A],
FKA [auth 1A],
FKC [auth 2A],
FKD [auth 2y],
FL [auth 1A],
FLA [auth 1A],
FLB [auth 2A],
FLC [auth 2A],
FM [auth 1A],
FMA [auth 1A],
FMB [auth 2A],
FMC [auth 2A],
FN [auth 1A],
FNA [auth 1A],
FNB [auth 2A],
FNC [auth 2A],
FO [auth 1A],
FOA [auth 1A],
FOB [auth 2A],
FOC [auth 2A],
FP [auth 1A],
FPA [auth 1A],
FPB [auth 2A],
FPC [auth 2A],
FQ [auth 1A],
FQA [auth 1A],
FQB [auth 2A],
FQC [auth 2A],
FR [auth 1A],
FRA [auth 1A],
FRB [auth 2A],
FRC [auth 2B],
FS [auth 1A],
FSA [auth 1B],
FSB [auth 2A],
FSC [auth 2B],
FT [auth 1A],
FTA [auth 1D],
FTB [auth 2A],
FTC [auth 2Q],
FU [auth 1A],
FUA [auth 1P],
FUB [auth 2A],
FUC [auth 25],
FV [auth 1A],
FVA [auth 1Z],
FVB [auth 2A],
FVC [auth 2a],
FW [auth 1A],
FWA [auth 1a],
FWB [auth 2A],
FWC [auth 2a],
FX [auth 1A],
FXA [auth 1a],
FXB [auth 2A],
FXC [auth 2a],
FY [auth 1A],
FYA [auth 1a],
FYB [auth 2A],
FYC [auth 2a],
FZ [auth 1A],
FZA [auth 1a],
FZB [auth 2A],
FZC [auth 2a],
GAA [auth 1A],
GAB [auth 1a],
GAC [auth 2A],
GAD [auth 2a],
GBA [auth 1A],
GBB [auth 1a],
GBC [auth 2A],
GBD [auth 2a],
GCA [auth 1A],
GCB [auth 1a],
GCC [auth 2A],
GCD [auth 2a],
GDA [auth 1A],
GDB [auth 1a],
GDC [auth 2A],
GDD [auth 2a],
GE [auth 1A],
GEA [auth 1A],
GEB [auth 1a],
GEC [auth 2A],
GED [auth 2a],
GF [auth 1A],
GFA [auth 1A],
GFB [auth 1a],
GFC [auth 2A],
GFD [auth 2a],
GG [auth 1A],
GGA [auth 1A],
GGB [auth 1a],
GGC [auth 2A],
GGD [auth 2a],
GH [auth 1A],
GHA [auth 1A],
GHB [auth 1a],
GHC [auth 2A],
GHD [auth 2b],
GI [auth 1A],
GIA [auth 1A],
GIB [auth 1a],
GIC [auth 2A],
GID [auth 2i],
GJ [auth 1A],
GJA [auth 1A],
GJB [auth 1m],
GJC [auth 2A],
GJD [auth 2s],
GK [auth 1A],
GKA [auth 1A],
GKB [auth 2A],
GKC [auth 2A],
GKD [auth 2y],
GL [auth 1A],
GLA [auth 1A],
GLB [auth 2A],
GLC [auth 2A],
GM [auth 1A],
GMA [auth 1A],
GMB [auth 2A],
GMC [auth 2A],
GN [auth 1A],
GNA [auth 1A],
GNB [auth 2A],
GNC [auth 2A],
GO [auth 1A],
GOA [auth 1A],
GOB [auth 2A],
GOC [auth 2A],
GP [auth 1A],
GPA [auth 1A],
GPB [auth 2A],
GPC [auth 2A],
GQ [auth 1A],
GQA [auth 1A],
GQB [auth 2A],
GQC [auth 2A],
GR [auth 1A],
GRA [auth 1A],
GRB [auth 2A],
GRC [auth 2B],
GS [auth 1A],
GSA [auth 1B],
GSB [auth 2A],
GSC [auth 2D],
GT [auth 1A],
GTA [auth 1D],
GTB [auth 2A],
GTC [auth 2Q],
GU [auth 1A],
GUA [auth 1P],
GUB [auth 2A],
GV [auth 1A],
GVA [auth 1Z],
GVB [auth 2A],
GVC [auth 2a],
GW [auth 1A],
GWA [auth 1a],
GWB [auth 2A],
GWC [auth 2a],
GX [auth 1A],
GXA [auth 1a],
GXB [auth 2A],
GXC [auth 2a],
GY [auth 1A],
GYA [auth 1a],
GYB [auth 2A],
GYC [auth 2a],
GZ [auth 1A],
GZA [auth 1a],
GZB [auth 2A],
GZC [auth 2a],
HAA [auth 1A],
HAB [auth 1a],
HAC [auth 2A],
HAD [auth 2a],
HBA [auth 1A],
HBB [auth 1a],
HBC [auth 2A],
HBD [auth 2a],
HCA [auth 1A],
HCB [auth 1a],
HCC [auth 2A],
HCD [auth 2a],
HDA [auth 1A],
HDB [auth 1a],
HDC [auth 2A],
HDD [auth 2a],
HE [auth 1A],
HEA [auth 1A],
HEB [auth 1a],
HEC [auth 2A],
HED [auth 2a],
HF [auth 1A],
HFA [auth 1A],
HFB [auth 1a],
HFC [auth 2A],
HFD [auth 2a],
HG [auth 1A],
HGA [auth 1A],
HGB [auth 1a],
HGC [auth 2A],
HGD [auth 2a],
HH [auth 1A],
HHA [auth 1A],
HHB [auth 1a],
HHC [auth 2A],
HHD [auth 2b],
HI [auth 1A],
HIA [auth 1A],
HIB [auth 1a],
HIC [auth 2A],
HID [auth 2i],
HJ [auth 1A],
HJA [auth 1A],
HJB [auth 1n],
HJC [auth 2A],
HJD [auth 2t],
HK [auth 1A],
HKA [auth 1A],
HKB [auth 2A],
HKC [auth 2A],
HKD [auth 2y],
HL [auth 1A],
HLA [auth 1A],
HLB [auth 2A],
HLC [auth 2A],
HM [auth 1A],
HMA [auth 1A],
HMB [auth 2A],
HMC [auth 2A],
HN [auth 1A],
HNA [auth 1A],
HNB [auth 2A],
HNC [auth 2A],
HO [auth 1A],
HOA [auth 1A],
HOB [auth 2A],
HOC [auth 2A],
HP [auth 1A],
HPA [auth 1A],
HPB [auth 2A],
HPC [auth 2A],
HQ [auth 1A],
HQA [auth 1A],
HQB [auth 2A],
HQC [auth 2A],
HR [auth 1A],
HRA [auth 1A],
HRB [auth 2A],
HRC [auth 2B],
HS [auth 1A],
HSA [auth 1B],
HSB [auth 2A],
HSC [auth 2D],
HT [auth 1A],
HTA [auth 1D],
HTB [auth 2A],
HTC [auth 2S],
HU [auth 1A],
HUA [auth 1P],
HUB [auth 2A],
HUC [auth 26],
HV [auth 1A],
HVA [auth 1Z],
HVB [auth 2A],
HVC [auth 2a],
HW [auth 1A],
HWA [auth 1a],
HWB [auth 2A],
HWC [auth 2a],
HX [auth 1A],
HXA [auth 1a],
HXB [auth 2A],
HXC [auth 2a],
HY [auth 1A],
HYA [auth 1a],
HYB [auth 2A],
HYC [auth 2a],
HZ [auth 1A],
HZA [auth 1a],
HZB [auth 2A],
HZC [auth 2a],
IAA [auth 1A],
IAB [auth 1a],
IAC [auth 2A],
IAD [auth 2a],
IBA [auth 1A],
IBB [auth 1a],
IBC [auth 2A],
IBD [auth 2a],
ICA [auth 1A],
ICB [auth 1a],
ICC [auth 2A],
ICD [auth 2a],
ID [auth 1A],
IDA [auth 1A],
IDB [auth 1a],
IDC [auth 2A],
IDD [auth 2a],
IE [auth 1A],
IEA [auth 1A],
IEB [auth 1a],
IEC [auth 2A],
IED [auth 2a],
IF [auth 1A],
IFA [auth 1A],
IFB [auth 1a],
IFC [auth 2A],
IFD [auth 2a],
IG [auth 1A],
IGA [auth 1A],
IGB [auth 1a],
IGC [auth 2A],
IGD [auth 2a],
IH [auth 1A],
IHA [auth 1A],
IHB [auth 1a],
IHC [auth 2A],
IHD [auth 2c],
II [auth 1A],
IIA [auth 1A],
IIB [auth 1a],
IIC [auth 2A],
IID [auth 2k],
IJ [auth 1A],
IJA [auth 1A],
IJB [auth 1n],
IJC [auth 2A],
IJD [auth 2u],
IK [auth 1A],
IKA [auth 1A],
IKB [auth 2A],
IKC [auth 2A],
IKD [auth 2y],
IL [auth 1A],
ILA [auth 1A],
ILB [auth 2A],
ILC [auth 2A],
IM [auth 1A],
IMA [auth 1A],
IMB [auth 2A],
IMC [auth 2A],
IN [auth 1A],
INA [auth 1A],
INB [auth 2A],
INC [auth 2A],
IO [auth 1A],
IOA [auth 1A],
IOB [auth 2A],
IOC [auth 2A],
IP [auth 1A],
IPA [auth 1A],
IPB [auth 2A],
IPC [auth 2A],
IQ [auth 1A],
IQA [auth 1A],
IQB [auth 2A],
IQC [auth 2A],
IR [auth 1A],
IRA [auth 1A],
IRB [auth 2A],
IRC [auth 2B],
IS [auth 1A],
ISA [auth 1B],
ISB [auth 2A],
ISC [auth 2D],
IT [auth 1A],
ITA [auth 1D],
ITB [auth 2A],
ITC [auth 2T],
IU [auth 1A],
IUA [auth 1P],
IUB [auth 2A],
IV [auth 1A],
IVA [auth 1Z],
IVB [auth 2A],
IVC [auth 2a],
IW [auth 1A],
IWA [auth 1a],
IWB [auth 2A],
IWC [auth 2a],
IX [auth 1A],
IXA [auth 1a],
IXB [auth 2A],
IXC [auth 2a],
IY [auth 1A],
IYA [auth 1a],
IYB [auth 2A],
IYC [auth 2a],
IZ [auth 1A],
IZA [auth 1a],
IZB [auth 2A],
IZC [auth 2a],
JAA [auth 1A],
JAB [auth 1a],
JAC [auth 2A],
JAD [auth 2a],
JBA [auth 1A],
JBB [auth 1a],
JBC [auth 2A],
JBD [auth 2a],
JCA [auth 1A],
JCB [auth 1a],
JCC [auth 2A],
JCD [auth 2a],
JD [auth 1A],
JDA [auth 1A],
JDB [auth 1a],
JDC [auth 2A],
JDD [auth 2a],
JE [auth 1A],
JEA [auth 1A],
JEB [auth 1a],
JEC [auth 2A],
JED [auth 2a],
JF [auth 1A],
JFA [auth 1A],
JFB [auth 1a],
JFC [auth 2A],
JFD [auth 2a],
JG [auth 1A],
JGA [auth 1A],
JGB [auth 1a],
JGC [auth 2A],
JGD [auth 2a],
JH [auth 1A],
JHA [auth 1A],
JHB [auth 1a],
JHC [auth 2A],
JHD [auth 2d],
JI [auth 1A],
JIA [auth 1A],
JIB [auth 1a],
JIC [auth 2A],
JID [auth 2k],
JJ [auth 1A],
JJA [auth 1A],
JJC [auth 2A],
JJD [auth 2u],
JK [auth 1A],
JKA [auth 1A],
JKB [auth 2A],
JKC [auth 2A],
JKD [auth 2z],
JL [auth 1A],
JLA [auth 1A],
JLB [auth 2A],
JLC [auth 2A],
JM [auth 1A],
JMA [auth 1A],
JMB [auth 2A],
JMC [auth 2A],
JN [auth 1A],
JNA [auth 1A],
JNB [auth 2A],
JNC [auth 2A],
JO [auth 1A],
JOA [auth 1A],
JOB [auth 2A],
JOC [auth 2A],
JP [auth 1A],
JPA [auth 1A],
JPB [auth 2A],
JPC [auth 2A],
JQ [auth 1A],
JQA [auth 1A],
JQB [auth 2A],
JQC [auth 2A],
JR [auth 1A],
JRA [auth 1A],
JRB [auth 2A],
JRC [auth 2B],
JS [auth 1A],
JSA [auth 1B],
JSB [auth 2A],
JSC [auth 2D],
JT [auth 1A],
JTA [auth 1D],
JTB [auth 2A],
JTC [auth 2T],
JU [auth 1A],
JUA [auth 1Q],
JUB [auth 2A],
JUC [auth 26],
JV [auth 1A],
JVA [auth 10],
JVB [auth 2A],
JVC [auth 2a],
JW [auth 1A],
JWA [auth 1a],
JWB [auth 2A],
JWC [auth 2a],
JX [auth 1A],
JXA [auth 1a],
JXB [auth 2A],
JXC [auth 2a],
JY [auth 1A],
JYA [auth 1a],
JYB [auth 2A],
JYC [auth 2a],
JZ [auth 1A],
JZA [auth 1a],
JZB [auth 2A],
JZC [auth 2a],
KAA [auth 1A],
KAB [auth 1a],
KAC [auth 2A],
KAD [auth 2a],
KBA [auth 1A],
KBB [auth 1a],
KBC [auth 2A],
KBD [auth 2a],
KCA [auth 1A],
KCB [auth 1a],
KCC [auth 2A],
KCD [auth 2a],
KD [auth 1A],
KDA [auth 1A],
KDB [auth 1a],
KDC [auth 2A],
KDD [auth 2a],
KE [auth 1A],
KEA [auth 1A],
KEB [auth 1a],
KEC [auth 2A],
KED [auth 2a],
KF [auth 1A],
KFA [auth 1A],
KFB [auth 1a],
KFC [auth 2A],
KFD [auth 2a],
KG [auth 1A],
KGA [auth 1A],
KGB [auth 1a],
KGC [auth 2A],
KGD [auth 2a],
KH [auth 1A],
KHA [auth 1A],
KHB [auth 1a],
KHC [auth 2A],
KHD [auth 2d],
KI [auth 1A],
KIA [auth 1A],
KIB [auth 1a],
KIC [auth 2A],
KID [auth 2l],
KJ [auth 1A],
KJA [auth 1A],
KJB [auth 1o],
KJC [auth 2A],
KJD [auth 2u],
KK [auth 1A],
KKA [auth 1A],
KKB [auth 2A],
KKC [auth 2A],
KKD [auth 2z],
KL [auth 1A],
KLA [auth 1A],
KLB [auth 2A],
KLC [auth 2A],
KM [auth 1A],
KMA [auth 1A],
KMB [auth 2A],
KMC [auth 2A],
KN [auth 1A],
KNA [auth 1A],
KNB [auth 2A],
KNC [auth 2A],
KO [auth 1A],
KOA [auth 1A],
KOB [auth 2A],
KOC [auth 2A],
KP [auth 1A],
KPA [auth 1A],
KPB [auth 2A],
KPC [auth 2A],
KQ [auth 1A],
KQA [auth 1A],
KQB [auth 2A],
KQC [auth 2A],
KR [auth 1A],
KRA [auth 1A],
KRB [auth 2A],
KRC [auth 2B],
KS [auth 1A],
KSA [auth 1B],
KSB [auth 2A],
KSC [auth 2D],
KT [auth 1A],
KTA [auth 1D],
KTB [auth 2A],
KTC [auth 2V],
KU [auth 1A],
KUA [auth 1Q],
KUB [auth 2A],
KUC [auth 27],
KV [auth 1A],
KVA [auth 10],
KVB [auth 2A],
KVC [auth 2a],
KW [auth 1A],
KWA [auth 1a],
KWB [auth 2A],
KWC [auth 2a],
KX [auth 1A],
KXA [auth 1a],
KXB [auth 2A],
KXC [auth 2a],
KY [auth 1A],
KYA [auth 1a],
KYB [auth 2A],
KYC [auth 2a],
KZ [auth 1A],
KZA [auth 1a],
KZB [auth 2A],
KZC [auth 2a],
LAA [auth 1A],
LAB [auth 1a],
LAC [auth 2A],
LAD [auth 2a],
LBA [auth 1A],
LBB [auth 1a],
LBC [auth 2A],
LBD [auth 2a],
LCA [auth 1A],
LCB [auth 1a],
LCC [auth 2A],
LCD [auth 2a],
LD [auth 1A],
LDA [auth 1A],
LDB [auth 1a],
LDC [auth 2A],
LDD [auth 2a],
LE [auth 1A],
LEA [auth 1A],
LEB [auth 1a],
LEC [auth 2A],
LED [auth 2a],
LF [auth 1A],
LFA [auth 1A],
LFB [auth 1a],
LFC [auth 2A],
LFD [auth 2a],
LG [auth 1A],
LGA [auth 1A],
LGB [auth 1a],
LGC [auth 2A],
LGD [auth 2a],
LH [auth 1A],
LHA [auth 1A],
LHB [auth 1a],
LHC [auth 2A],
LI [auth 1A],
LIA [auth 1A],
LIB [auth 1b],
LIC [auth 2A],
LID [auth 2l],
LJ [auth 1A],
LJA [auth 1A],
LJB [auth 1p],
LJC [auth 2A],
LJD [auth 2v],
LK [auth 1A],
LKA [auth 1A],
LKB [auth 2A],
LKC [auth 2A],
LKD [auth 2z],
LL [auth 1A],
LLA [auth 1A],
LLB [auth 2A],
LLC [auth 2A],
LM [auth 1A],
LMA [auth 1A],
LMB [auth 2A],
LMC [auth 2A],
LN [auth 1A],
LNA [auth 1A],
LNB [auth 2A],
LNC [auth 2A],
LO [auth 1A],
LOA [auth 1A],
LOB [auth 2A],
LOC [auth 2A],
LP [auth 1A],
LPA [auth 1A],
LPB [auth 2A],
LPC [auth 2A],
LQ [auth 1A],
LQA [auth 1A],
LQB [auth 2A],
LQC [auth 2A],
LR [auth 1A],
LRA [auth 1A],
LRB [auth 2A],
LRC [auth 2B],
LS [auth 1A],
LSA [auth 1B],
LSB [auth 2A],
LSC [auth 2D],
LT [auth 1A],
LTA [auth 1D],
LTB [auth 2A],
LTC [auth 2X],
LU [auth 1A],
LUA [auth 1Q],
LUB [auth 2A],
LUC [auth 27],
LV [auth 1A],
LVA [auth 10],
LVB [auth 2A],
LVC [auth 2a],
LW [auth 1A],
LWA [auth 1a],
LWB [auth 2A],
LWC [auth 2a],
LX [auth 1A],
LXA [auth 1a],
LXB [auth 2A],
LXC [auth 2a],
LY [auth 1A],
LYA [auth 1a],
LYB [auth 2A],
LYC [auth 2a],
LZ [auth 1A],
LZA [auth 1a],
LZB [auth 2A],
LZC [auth 2a],
MAA [auth 1A],
MAB [auth 1a],
MAC [auth 2A],
MAD [auth 2a],
MBA [auth 1A],
MBB [auth 1a],
MBC [auth 2A],
MBD [auth 2a],
MCA [auth 1A],
MCB [auth 1a],
MCC [auth 2A],
MCD [auth 2a],
MD [auth 1A],
MDA [auth 1A],
MDB [auth 1a],
MDC [auth 2A],
MDD [auth 2a],
ME [auth 1A],
MEA [auth 1A],
MEB [auth 1a],
MEC [auth 2A],
MED [auth 2a],
MF [auth 1A],
MFA [auth 1A],
MFB [auth 1a],
MFC [auth 2A],
MFD [auth 2a],
MG [auth 1A],
MGA [auth 1A],
MGB [auth 1a],
MGC [auth 2A],
MGD [auth 2a],
MH [auth 1A],
MHA [auth 1A],
MHB [auth 1a],
MHC [auth 2A],
MHD [auth 2d],
MI [auth 1A],
MIA [auth 1A],
MIB [auth 1b],
MIC [auth 2A],
MID [auth 2l],
MJ [auth 1A],
MJA [auth 1A],
MJB [auth 1q],
MJC [auth 2A],
MJD [auth 2v],
MK [auth 1A],
MKA [auth 1A],
MKB [auth 2A],
MKC [auth 2A],
ML [auth 1A],
MLA [auth 1A],
MLB [auth 2A],
MLC [auth 2A],
MM [auth 1A],
MMA [auth 1A],
MMB [auth 2A],
MMC [auth 2A],
MN [auth 1A],
MNA [auth 1A],
MNB [auth 2A],
MNC [auth 2A],
MO [auth 1A],
MOA [auth 1A],
MOB [auth 2A],
MOC [auth 2A],
MP [auth 1A],
MPA [auth 1A],
MPB [auth 2A],
MPC [auth 2A],
MQ [auth 1A],
MQA [auth 1A],
MQB [auth 2A],
MQC [auth 2A],
MR [auth 1A],
MRA [auth 1A],
MRB [auth 2A],
MRC [auth 2B],
MS [auth 1A],
MSA [auth 1B],
MSB [auth 2A],
MSC [auth 2E],
MT [auth 1A],
MTA [auth 1D],
MTB [auth 2A],
MTC [auth 2Y],
MU [auth 1A],
MUA [auth 1R],
MUB [auth 2A],
MUC [auth 27],
MV [auth 1A],
MVA [auth 10],
MVB [auth 2A],
MVC [auth 2a],
MW [auth 1A],
MWA [auth 1a],
MWB [auth 2A],
MWC [auth 2a],
MX [auth 1A],
MXA [auth 1a],
MXB [auth 2A],
MXC [auth 2a],
MY [auth 1A],
MYA [auth 1a],
MYB [auth 2A],
MYC [auth 2a],
MZ [auth 1A],
MZA [auth 1a],
MZB [auth 2A],
MZC [auth 2a],
NAA [auth 1A],
NAB [auth 1a],
NAC [auth 2A],
NAD [auth 2a],
NBA [auth 1A],
NBB [auth 1a],
NBC [auth 2A],
NBD [auth 2a],
NCA [auth 1A],
NCB [auth 1a],
NCC [auth 2A],
NCD [auth 2a],
ND [auth 1A],
NDA [auth 1A],
NDB [auth 1a],
NDC [auth 2A],
NDD [auth 2a],
NE [auth 1A],
NEA [auth 1A],
NEB [auth 1a],
NEC [auth 2A],
NED [auth 2a],
NF [auth 1A],
NFA [auth 1A],
NFB [auth 1a],
NFC [auth 2A],
NFD [auth 2a],
NG [auth 1A],
NGA [auth 1A],
NGB [auth 1a],
NGC [auth 2A],
NGD [auth 2a],
NH [auth 1A],
NHA [auth 1A],
NHB [auth 1a],
NHC [auth 2A],
NHD [auth 2e],
NI [auth 1A],
NIA [auth 1A],
NIB [auth 1b],
NIC [auth 2A],
NID [auth 2l],
NJ [auth 1A],
NJA [auth 1A],
NJB [auth 1s],
NJC [auth 2A],
NJD [auth 2v],
NK [auth 1A],
NKA [auth 1A],
NKB [auth 2A],
NKC [auth 2A],
NL [auth 1A],
NLA [auth 1A],
NLB [auth 2A],
NLC [auth 2A],
NM [auth 1A],
NMA [auth 1A],
NMB [auth 2A],
NMC [auth 2A],
NN [auth 1A],
NNA [auth 1A],
NNB [auth 2A],
NNC [auth 2A],
NO [auth 1A],
NOA [auth 1A],
NOB [auth 2A],
NOC [auth 2A],
NP [auth 1A],
NPA [auth 1A],
NPB [auth 2A],
NPC [auth 2A],
NQ [auth 1A],
NQA [auth 1A],
NQB [auth 2A],
NQC [auth 2A],
NR [auth 1A],
NRA [auth 1A],
NRB [auth 2A],
NRC [auth 2B],
NS [auth 1A],
NSA [auth 1B],
NSB [auth 2A],
NSC [auth 2E],
NT [auth 1A],
NTA [auth 1E],
NTB [auth 2A],
NTC [auth 2Y],
NU [auth 1A],
NUA [auth 1R],
NUB [auth 2A],
NUC [auth 28],
NV [auth 1A],
NVA [auth 11],
NVB [auth 2A],
NVC [auth 2a],
NW [auth 1A],
NWA [auth 1a],
NWB [auth 2A],
NWC [auth 2a],
NX [auth 1A],
NXA [auth 1a],
NXB [auth 2A],
NXC [auth 2a],
NY [auth 1A],
NYA [auth 1a],
NYB [auth 2A],
NYC [auth 2a],
NZ [auth 1A],
NZA [auth 1a],
NZB [auth 2A],
NZC [auth 2a],
OAA [auth 1A],
OAB [auth 1a],
OAC [auth 2A],
OAD [auth 2a],
OBA [auth 1A],
OBB [auth 1a],
OBC [auth 2A],
OBD [auth 2a],
OCA [auth 1A],
OCB [auth 1a],
OCC [auth 2A],
OCD [auth 2a],
OD [auth 1A],
ODA [auth 1A],
ODB [auth 1a],
ODC [auth 2A],
ODD [auth 2a],
OE [auth 1A],
OEA [auth 1A],
OEB [auth 1a],
OEC [auth 2A],
OED [auth 2a],
OF [auth 1A],
OFA [auth 1A],
OFB [auth 1a],
OFC [auth 2A],
OFD [auth 2a],
OG [auth 1A],
OGA [auth 1A],
OGB [auth 1a],
OGC [auth 2A],
OGD [auth 2a],
OH [auth 1A],
OHA [auth 1A],
OHB [auth 1a],
OHC [auth 2A],
OHD [auth 2e],
OI [auth 1A],
OIA [auth 1A],
OIB [auth 1b],
OIC [auth 2A],
OID [auth 2l],
OJ [auth 1A],
OJA [auth 1A],
OJB [auth 1s],
OJC [auth 2A],
OK [auth 1A],
OKA [auth 1A],
OKB [auth 2A],
OKC [auth 2A],
OL [auth 1A],
OLA [auth 1A],
OLB [auth 2A],
OLC [auth 2A],
OM [auth 1A],
OMA [auth 1A],
OMB [auth 2A],
OMC [auth 2A],
ON [auth 1A],
ONA [auth 1A],
ONB [auth 2A],
ONC [auth 2A],
OO [auth 1A],
OOA [auth 1A],
OOB [auth 2A],
OOC [auth 2A],
OP [auth 1A],
OPA [auth 1A],
OPB [auth 2A],
OPC [auth 2A],
OQ [auth 1A],
OQA [auth 1A],
OQB [auth 2A],
OQC [auth 2A],
OR [auth 1A],
ORA [auth 1A],
ORB [auth 2A],
ORC [auth 2B],
OS [auth 1A],
OSA [auth 1B],
OSB [auth 2A],
OSC [auth 2E],
OT [auth 1A],
OTA [auth 1E],
OTB [auth 2A],
OU [auth 1A],
OUA [auth 1R],
OUB [auth 2A],
OUC [auth 28],
OV [auth 1A],
OVA [auth 12],
OVB [auth 2A],
OVC [auth 2a],
OW [auth 1A],
OWA [auth 1a],
OWB [auth 2A],
OWC [auth 2a],
OX [auth 1A],
OXA [auth 1a],
OXB [auth 2A],
OXC [auth 2a],
OY [auth 1A],
OYA [auth 1a],
OYB [auth 2A],
OYC [auth 2a],
OZ [auth 1A],
OZA [auth 1a],
OZB [auth 2A],
OZC [auth 2a],
PAA [auth 1A],
PAB [auth 1a],
PAC [auth 2A],
PAD [auth 2a],
PBA [auth 1A],
PBB [auth 1a],
PBC [auth 2A],
PBD [auth 2a],
PCA [auth 1A],
PCB [auth 1a],
PCC [auth 2A],
PCD [auth 2a],
PD [auth 1A],
PDA [auth 1A],
PDB [auth 1a],
PDC [auth 2A],
PDD [auth 2a],
PE [auth 1A],
PEA [auth 1A],
PEB [auth 1a],
PEC [auth 2A],
PED [auth 2a],
PF [auth 1A],
PFA [auth 1A],
PFB [auth 1a],
PFC [auth 2A],
PFD [auth 2a],
PG [auth 1A],
PGA [auth 1A],
PGB [auth 1a],
PGC [auth 2A],
PGD [auth 2a],
PH [auth 1A],
PHA [auth 1A],
PHB [auth 1a],
PHC [auth 2A],
PHD [auth 2f],
PI [auth 1A],
PIA [auth 1A],
PIB [auth 1b],
PIC [auth 2A],
PID [auth 2l],
PJ [auth 1A],
PJA [auth 1A],
PJB [auth 1s],
PJC [auth 2A],
PJD [auth 2w],
PK [auth 1A],
PKA [auth 1A],
PKB [auth 2A],
PKC [auth 2A],
PL [auth 1A],
PLA [auth 1A],
PLB [auth 2A],
PLC [auth 2A],
PM [auth 1A],
PMA [auth 1A],
PMB [auth 2A],
PMC [auth 2A],
PN [auth 1A],
PNA [auth 1A],
PNB [auth 2A],
PNC [auth 2A],
PO [auth 1A],
POA [auth 1A],
POB [auth 2A],
POC [auth 2A],
PP [auth 1A],
PPA [auth 1A],
PPB [auth 2A],
PPC [auth 2A],
PQ [auth 1A],
PQA [auth 1A],
PQB [auth 2A],
PQC [auth 2A],
PR [auth 1A],
PRA [auth 1A],
PRB [auth 2A],
PRC [auth 2B],
PS [auth 1A],
PSA [auth 1B],
PSB [auth 2A],
PSC [auth 2E],
PT [auth 1A],
PTA [auth 1E],
PTB [auth 2A],
PTC [auth 2Z],
PU [auth 1A],
PUA [auth 1S],
PUB [auth 2A],
PUC [auth 28],
PV [auth 1A],
PVA [auth 13],
PVB [auth 2A],
PVC [auth 2a],
PW [auth 1A],
PWA [auth 1a],
PWB [auth 2A],
PWC [auth 2a],
PX [auth 1A],
PXA [auth 1a],
PXB [auth 2A],
PXC [auth 2a],
PY [auth 1A],
PYA [auth 1a],
PYB [auth 2A],
PYC [auth 2a],
PZ [auth 1A],
PZA [auth 1a],
PZB [auth 2A],
PZC [auth 2a],
QAA [auth 1A],
QAB [auth 1a],
QAC [auth 2A],
QAD [auth 2a],
QBA [auth 1A],
QBB [auth 1a],
QBC [auth 2A],
QBD [auth 2a],
QCA [auth 1A],
QCB [auth 1a],
QCC [auth 2A],
QCD [auth 2a],
QD [auth 1A],
QDA [auth 1A],
QDB [auth 1a],
QDC [auth 2A],
QDD [auth 2a],
QE [auth 1A],
QEA [auth 1A],
QEB [auth 1a],
QEC [auth 2A],
QED [auth 2a],
QF [auth 1A],
QFA [auth 1A],
QFB [auth 1a],
QFC [auth 2A],
QFD [auth 2a],
QG [auth 1A],
QGA [auth 1A],
QGB [auth 1a],
QGC [auth 2A],
QGD [auth 2a],
QH [auth 1A],
QHA [auth 1A],
QHB [auth 1a],
QHC [auth 2A],
QHD [auth 2f],
QI [auth 1A],
QIA [auth 1A],
QIB [auth 1b],
QIC [auth 2A],
QID [auth 2m],
QJ [auth 1A],
QJA [auth 1A],
QJB [auth 1t],
QJC [auth 2A],
QJD [auth 2w],
QK [auth 1A],
QKA [auth 1A],
QKB [auth 2A],
QKC [auth 2A],
QL [auth 1A],
QLA [auth 1A],
QLB [auth 2A],
QLC [auth 2A],
QM [auth 1A],
QMA [auth 1A],
QMB [auth 2A],
QMC [auth 2A],
QN [auth 1A],
QNA [auth 1A],
QNB [auth 2A],
QNC [auth 2A],
QO [auth 1A],
QOA [auth 1A],
QOB [auth 2A],
QOC [auth 2A],
QP [auth 1A],
QPA [auth 1A],
QPB [auth 2A],
QPC [auth 2A],
QQ [auth 1A],
QQA [auth 1A],
QQB [auth 2A],
QQC [auth 2A],
QR [auth 1A],
QRA [auth 1A],
QRB [auth 2A],
QRC [auth 2B],
QS [auth 1A],
QSA [auth 1B],
QSB [auth 2A],
QSC [auth 2E],
QT [auth 1A],
QTA [auth 1E],
QTB [auth 2A],
QTC [auth 2Z],
QU [auth 1A],
QUA [auth 1S],
QUB [auth 2A],
QUC [auth 28],
QV [auth 1A],
QVB [auth 2A],
QVC [auth 2a],
QW [auth 1A],
QWA [auth 1a],
QWB [auth 2A],
QWC [auth 2a],
QX [auth 1A],
QXA [auth 1a],
QXB [auth 2A],
QXC [auth 2a],
QY [auth 1A],
QYA [auth 1a],
QYB [auth 2A],
QYC [auth 2a],
QZ [auth 1A],
QZA [auth 1a],
QZB [auth 2A],
QZC [auth 2a],
RAA [auth 1A],
RAB [auth 1a],
RAC [auth 2A],
RAD [auth 2a],
RBA [auth 1A],
RBB [auth 1a],
RBC [auth 2A],
RBD [auth 2a],
RCA [auth 1A],
RCB [auth 1a],
RCC [auth 2A],
RCD [auth 2a],
RD [auth 1A],
RDA [auth 1A],
RDB [auth 1a],
RDC [auth 2A],
RDD [auth 2a],
RE [auth 1A],
REA [auth 1A],
REB [auth 1a],
REC [auth 2A],
RED [auth 2a],
RF [auth 1A],
RFA [auth 1A],
RFB [auth 1a],
RFC [auth 2A],
RFD [auth 2a],
RG [auth 1A],
RGA [auth 1A],
RGB [auth 1a],
RGC [auth 2A],
RGD [auth 2a],
RH [auth 1A],
RHA [auth 1A],
RHB [auth 1a],
RHC [auth 2A],
RHD [auth 2f],
RI [auth 1A],
RIA [auth 1A],
RIB [auth 1b],
RIC [auth 2A],
RID [auth 2m],
RJ [auth 1A],
RJA [auth 1A],
RJB [auth 1u],
RJC [auth 2A],
RJD [auth 2x],
RK [auth 1A],
RKA [auth 1A],
RKB [auth 2A],
RKC [auth 2A],
RL [auth 1A],
RLA [auth 1A],
RLB [auth 2A],
RLC [auth 2A],
RM [auth 1A],
RMA [auth 1A],
RMB [auth 2A],
RMC [auth 2A],
RN [auth 1A],
RNA [auth 1A],
RNB [auth 2A],
RNC [auth 2A],
RO [auth 1A],
ROA [auth 1A],
ROB [auth 2A],
ROC [auth 2A],
RP [auth 1A],
RPA [auth 1A],
RPB [auth 2A],
RPC [auth 2A],
RQ [auth 1A],
RQA [auth 1A],
RQB [auth 2A],
RQC [auth 2A],
RR [auth 1A],
RRA [auth 1A],
RRB [auth 2A],
RRC [auth 2B],
RS [auth 1A],
RSA [auth 1B],
RSB [auth 2A],
RSC [auth 2F],
RT [auth 1A],
RTA [auth 1E],
RTB [auth 2A],
RTC [auth 2Z],
RU [auth 1A],
RUA [auth 1T],
RUB [auth 2A],
RUC [auth 28],
RV [auth 1A],
RVA [auth 15],
RVB [auth 2A],
RVC [auth 2a],
RW [auth 1A],
RWA [auth 1a],
RWB [auth 2A],
RWC [auth 2a],
RX [auth 1A],
RXA [auth 1a],
RXB [auth 2A],
RXC [auth 2a],
RY [auth 1A],
RYA [auth 1a],
RYB [auth 2A],
RYC [auth 2a],
RZ [auth 1A],
RZA [auth 1a],
RZB [auth 2A],
RZC [auth 2a],
SAA [auth 1A],
SAB [auth 1a],
SAC [auth 2A],
SAD [auth 2a],
SBA [auth 1A],
SBB [auth 1a],
SBC [auth 2A],
SBD [auth 2a],
SCA [auth 1A],
SCB [auth 1a],
SCC [auth 2A],
SCD [auth 2a],
SD [auth 1A],
SDA [auth 1A],
SDB [auth 1a],
SDC [auth 2A],
SDD [auth 2a],
SE [auth 1A],
SEA [auth 1A],
SEB [auth 1a],
SEC [auth 2A],
SED [auth 2a],
SF [auth 1A],
SFA [auth 1A],
SFB [auth 1a],
SFC [auth 2A],
SFD [auth 2a],
SG [auth 1A],
SGA [auth 1A],
SGB [auth 1a],
SGC [auth 2A],
SGD [auth 2a],
SH [auth 1A],
SHA [auth 1A],
SHB [auth 1a],
SHC [auth 2A],
SHD [auth 2f],
SI [auth 1A],
SIA [auth 1A],
SIB [auth 1b],
SIC [auth 2A],
SID [auth 2m],
SJ [auth 1A],
SJA [auth 1A],
SJB [auth 1v],
SJC [auth 2A],
SJD [auth 2x],
SK [auth 1A],
SKA [auth 1A],
SKB [auth 2A],
SKC [auth 2A],
SL [auth 1A],
SLA [auth 1A],
SLB [auth 2A],
SLC [auth 2A],
SM [auth 1A],
SMA [auth 1A],
SMB [auth 2A],
SMC [auth 2A],
SN [auth 1A],
SNA [auth 1A],
SNB [auth 2A],
SNC [auth 2A],
SO [auth 1A],
SOA [auth 1A],
SOB [auth 2A],
SOC [auth 2A],
SP [auth 1A],
SPA [auth 1A],
SPB [auth 2A],
SPC [auth 2A],
SQ [auth 1A],
SQA [auth 1A],
SQB [auth 2A],
SQC [auth 2A],
SR [auth 1A],
SRA [auth 1A],
SRB [auth 2A],
SRC [auth 2B],
SS [auth 1A],
SSA [auth 1B],
SSB [auth 2A],
SSC [auth 2F],
ST [auth 1A],
STA [auth 1E],
STB [auth 2A],
STC [auth 2Z],
SU [auth 1A],
SUA [auth 1T],
SUB [auth 2A],
SUC [auth 28],
SV [auth 1A],
SVA [auth 15],
SVB [auth 2A],
SVC [auth 2a],
SW [auth 1A],
SWA [auth 1a],
SWB [auth 2A],
SWC [auth 2a],
SX [auth 1A],
SXA [auth 1a],
SXB [auth 2A],
SXC [auth 2a],
SY [auth 1A],
SYA [auth 1a],
SYB [auth 2A],
SYC [auth 2a],
SZ [auth 1A],
SZA [auth 1a],
SZB [auth 2A],
SZC [auth 2a],
TAA [auth 1A],
TAB [auth 1a],
TAC [auth 2A],
TAD [auth 2a],
TBA [auth 1A],
TBB [auth 1a],
TBC [auth 2A],
TBD [auth 2a],
TCA [auth 1A],
TCB [auth 1a],
TCC [auth 2A],
TCD [auth 2a],
TD [auth 1A],
TDA [auth 1A],
TDB [auth 1a],
TDC [auth 2A],
TDD [auth 2a],
TE [auth 1A],
TEA [auth 1A],
TEB [auth 1a],
TEC [auth 2A],
TED [auth 2a],
TF [auth 1A],
TFA [auth 1A],
TFB [auth 1a],
TFC [auth 2A],
TFD [auth 2a],
TG [auth 1A],
TGA [auth 1A],
TGB [auth 1a],
TGC [auth 2A],
TGD [auth 2a],
TH [auth 1A],
THA [auth 1A],
THB [auth 1a],
THC [auth 2A],
THD [auth 2g],
TI [auth 1A],
TIA [auth 1A],
TIB [auth 1b],
TIC [auth 2A],
TJ [auth 1A],
TJA [auth 1A],
TJB [auth 1v],
TJC [auth 2A],
TJD [auth 2x],
TK [auth 1A],
TKA [auth 1A],
TKB [auth 2A],
TKC [auth 2A],
TL [auth 1A],
TLA [auth 1A],
TLB [auth 2A],
TLC [auth 2A],
TM [auth 1A],
TMA [auth 1A],
TMB [auth 2A],
TMC [auth 2A],
TN [auth 1A],
TNA [auth 1A],
TNB [auth 2A],
TNC [auth 2A],
TO [auth 1A],
TOA [auth 1A],
TOB [auth 2A],
TOC [auth 2A],
TP [auth 1A],
TPA [auth 1A],
TPB [auth 2A],
TPC [auth 2A],
TQ [auth 1A],
TQA [auth 1A],
TQB [auth 2A],
TQC [auth 2A],
TR [auth 1A],
TRA [auth 1A],
TRB [auth 2A],
TRC [auth 2B],
TS [auth 1A],
TSA [auth 1B],
TSB [auth 2A],
TSC [auth 2F],
TT [auth 1A],
TTA [auth 1E],
TTB [auth 2A],
TTC [auth 20],
TU [auth 1A],
TUA [auth 1T],
TUB [auth 2A],
TUC [auth 29],
TV [auth 1A],
TVB [auth 2A],
TVC [auth 2a],
TW [auth 1A],
TWA [auth 1a],
TWB [auth 2A],
TWC [auth 2a],
TX [auth 1A],
TXA [auth 1a],
TXB [auth 2A],
TXC [auth 2a],
TY [auth 1A],
TYA [auth 1a],
TYB [auth 2A],
TYC [auth 2a],
TZ [auth 1A],
TZA [auth 1a],
TZB [auth 2A],
TZC [auth 2a],
UAA [auth 1A],
UAB [auth 1a],
UAC [auth 2A],
UAD [auth 2a],
UBA [auth 1A],
UBB [auth 1a],
UBC [auth 2A],
UBD [auth 2a],
UCA [auth 1A],
UCB [auth 1a],
UCC [auth 2A],
UCD [auth 2a],
UD [auth 1A],
UDA [auth 1A],
UDB [auth 1a],
UDC [auth 2A],
UDD [auth 2a],
UE [auth 1A],
UEA [auth 1A],
UEB [auth 1a],
UEC [auth 2A],
UED [auth 2a],
UF [auth 1A],
UFA [auth 1A],
UFB [auth 1a],
UFC [auth 2A],
UFD [auth 2a],
UG [auth 1A],
UGA [auth 1A],
UGB [auth 1a],
UGC [auth 2A],
UGD [auth 2a],
UH [auth 1A],
UHA [auth 1A],
UHB [auth 1a],
UHC [auth 2A],
UHD [auth 2g],
UI [auth 1A],
UIA [auth 1A],
UIB [auth 1d],
UIC [auth 2A],
UID [auth 2o],
UJ [auth 1A],
UJA [auth 1A],
UJB [auth 1v],
UJC [auth 2A],
UJD [auth 2x],
UK [auth 1A],
UKA [auth 1A],
UKB [auth 2A],
UKC [auth 2A],
UL [auth 1A],
ULA [auth 1A],
ULB [auth 2A],
ULC [auth 2A],
UM [auth 1A],
UMA [auth 1A],
UMB [auth 2A],
UMC [auth 2A],
UN [auth 1A],
UNA [auth 1A],
UNB [auth 2A],
UNC [auth 2A],
UO [auth 1A],
UOA [auth 1A],
UOB [auth 2A],
UOC [auth 2A],
UP [auth 1A],
UPA [auth 1A],
UPB [auth 2A],
UPC [auth 2A],
UQ [auth 1A],
UQA [auth 1A],
UQB [auth 2A],
UQC [auth 2A],
UR [auth 1A],
URA [auth 1A],
URB [auth 2A],
URC [auth 2B],
US [auth 1A],
USA [auth 1B],
USB [auth 2A],
USC [auth 2F],
UT [auth 1A],
UTA [auth 1E],
UTB [auth 2A],
UTC [auth 20],
UU [auth 1A],
UUA [auth 1T],
UUB [auth 2A],
UUC [auth 29],
UV [auth 1A],
UVA [auth 16],
UVB [auth 2A],
UVC [auth 2a],
UW [auth 1A],
UWA [auth 1a],
UWB [auth 2A],
UWC [auth 2a],
UX [auth 1A],
UXA [auth 1a],
UXB [auth 2A],
UXC [auth 2a],
UY [auth 1A],
UYA [auth 1a],
UYB [auth 2A],
UYC [auth 2a],
UZ [auth 1A],
UZA [auth 1a],
UZB [auth 2A],
UZC [auth 2a],
VAA [auth 1A],
VAB [auth 1a],
VAC [auth 2A],
VAD [auth 2a],
VBA [auth 1A],
VBB [auth 1a],
VBC [auth 2A],
VBD [auth 2a],
VCA [auth 1A],
VCB [auth 1a],
VCC [auth 2A],
VCD [auth 2a],
VD [auth 1A],
VDA [auth 1A],
VDB [auth 1a],
VDC [auth 2A],
VDD [auth 2a],
VE [auth 1A],
VEA [auth 1A],
VEB [auth 1a],
VEC [auth 2A],
VED [auth 2a],
VF [auth 1A],
VFA [auth 1A],
VFB [auth 1a],
VFC [auth 2A],
VFD [auth 2a],
VG [auth 1A],
VGA [auth 1A],
VGB [auth 1a],
VGC [auth 2A],
VGD [auth 2a],
VH [auth 1A],
VHA [auth 1A],
VHB [auth 1a],
VHC [auth 2A],
VHD [auth 2g],
VI [auth 1A],
VIA [auth 1A],
VIB [auth 1d],
VIC [auth 2A],
VID [auth 2p],
VJ [auth 1A],
VJA [auth 1A],
VJC [auth 2A],
VJD [auth 2x],
VK [auth 1A],
VKA [auth 1A],
VKB [auth 2A],
VKC [auth 2A],
VL [auth 1A],
VLA [auth 1A],
VLB [auth 2A],
VLC [auth 2A],
VM [auth 1A],
VMA [auth 1A],
VMB [auth 2A],
VMC [auth 2A],
VN [auth 1A],
VNA [auth 1A],
VNB [auth 2A],
VNC [auth 2A],
VO [auth 1A],
VOA [auth 1A],
VOB [auth 2A],
VOC [auth 2A],
VP [auth 1A],
VPA [auth 1A],
VPB [auth 2A],
VPC [auth 2A],
VQ [auth 1A],
VQA [auth 1A],
VQB [auth 2A],
VQC [auth 2A],
VR [auth 1A],
VRA [auth 1A],
VRB [auth 2A],
VRC [auth 2B],
VS [auth 1A],
VSA [auth 1B],
VSB [auth 2A],
VSC [auth 2N],
VT [auth 1A],
VTA [auth 1F],
VTB [auth 2A],
VTC [auth 20],
VU [auth 1A],
VUA [auth 1T],
VUB [auth 2A],
VV [auth 1A],
VVB [auth 2A],
VVC [auth 2a],
VW [auth 1A],
VWA [auth 1a],
VWB [auth 2A],
VWC [auth 2a],
VX [auth 1A],
VXA [auth 1a],
VXB [auth 2A],
VXC [auth 2a],
VY [auth 1A],
VYA [auth 1a],
VYB [auth 2A],
VYC [auth 2a],
VZ [auth 1A],
VZA [auth 1a],
VZB [auth 2A],
VZC [auth 2a],
WAA [auth 1A],
WAB [auth 1a],
WAC [auth 2A],
WAD [auth 2a],
WBA [auth 1A],
WBB [auth 1a],
WBC [auth 2A],
WBD [auth 2a],
WCA [auth 1A],
WCB [auth 1a],
WCC [auth 2A],
WCD [auth 2a],
WD [auth 1A],
WDA [auth 1A],
WDB [auth 1a],
WDC [auth 2A],
WDD [auth 2a],
WE [auth 1A],
WEA [auth 1A],
WEB [auth 1a],
WEC [auth 2A],
WED [auth 2a],
WF [auth 1A],
WFA [auth 1A],
WFB [auth 1a],
WFC [auth 2A],
WFD [auth 2a],
WG [auth 1A],
WGA [auth 1A],
WGB [auth 1a],
WGC [auth 2A],
WGD [auth 2a],
WH [auth 1A],
WHA [auth 1A],
WHB [auth 1a],
WHC [auth 2A],
WHD [auth 2g],
WI [auth 1A],
WIA [auth 1A],
WIB [auth 1d],
WIC [auth 2A],
WID [auth 2p],
WJ [auth 1A],
WJA [auth 1A],
WJB [auth 1x],
WJC [auth 2A],
WJD [auth 2x],
WK [auth 1A],
WKA [auth 1A],
WKB [auth 2A],
WKC [auth 2A],
WL [auth 1A],
WLA [auth 1A],
WLB [auth 2A],
WLC [auth 2A],
WM [auth 1A],
WMA [auth 1A],
WMB [auth 2A],
WMC [auth 2A],
WN [auth 1A],
WNA [auth 1A],
WNB [auth 2A],
WNC [auth 2A],
WO [auth 1A],
WOA [auth 1A],
WOB [auth 2A],
WOC [auth 2A],
WP [auth 1A],
WPA [auth 1A],
WPB [auth 2A],
WPC [auth 2A],
WQ [auth 1A],
WQA [auth 1A],
WQB [auth 2A],
WQC [auth 2A],
WR [auth 1A],
WRA [auth 1A],
WRB [auth 2A],
WRC [auth 2B],
WS [auth 1A],
WSA [auth 1B],
WSB [auth 2A],
WSC [auth 2N],
WT [auth 1A],
WTA [auth 1H],
WTB [auth 2A],
WTC [auth 20],
WU [auth 1A],
WUA [auth 1U],
WUB [auth 2A],
WUC [auth 2a],
WV [auth 1A],
WVA [auth 17],
WVB [auth 2A],
WVC [auth 2a],
WW [auth 1A],
WWA [auth 1a],
WWB [auth 2A],
WWC [auth 2a],
WX [auth 1A],
WXA [auth 1a],
WXB [auth 2A],
WXC [auth 2a],
WY [auth 1A],
WYA [auth 1a],
WYB [auth 2A],
WYC [auth 2a],
WZ [auth 1A],
WZA [auth 1a],
WZB [auth 2A],
WZC [auth 2a],
XAA [auth 1A],
XAB [auth 1a],
XAC [auth 2A],
XAD [auth 2a],
XBA [auth 1A],
XBB [auth 1a],
XBC [auth 2A],
XBD [auth 2a],
XCA [auth 1A],
XCB [auth 1a],
XCC [auth 2A],
XCD [auth 2a],
XD [auth 1A],
XDA [auth 1A],
XDB [auth 1a],
XDC [auth 2A],
XDD [auth 2a],
XE [auth 1A],
XEA [auth 1A],
XEB [auth 1a],
XEC [auth 2A],
XED [auth 2a],
XF [auth 1A],
XFA [auth 1A],
XFB [auth 1a],
XFC [auth 2A],
XFD [auth 2a],
XG [auth 1A],
XGA [auth 1A],
XGB [auth 1a],
XGC [auth 2A],
XGD [auth 2a],
XH [auth 1A],
XHA [auth 1A],
XHB [auth 1a],
XHC [auth 2A],
XHD [auth 2g],
XI [auth 1A],
XIA [auth 1A],
XIC [auth 2A],
XID [auth 2p],
XJ [auth 1A],
XJA [auth 1A],
XJB [auth 1x],
XJC [auth 2A],
XJD [auth 2x],
XK [auth 1A],
XKA [auth 1A],
XKB [auth 2A],
XKC [auth 2A],
XL [auth 1A],
XLA [auth 1A],
XLB [auth 2A],
XLC [auth 2A],
XM [auth 1A],
XMA [auth 1A],
XMB [auth 2A],
XMC [auth 2A],
XN [auth 1A],
XNA [auth 1A],
XNB [auth 2A],
XNC [auth 2A],
XO [auth 1A],
XOA [auth 1A],
XOB [auth 2A],
XOC [auth 2A],
XP [auth 1A],
XPA [auth 1A],
XPB [auth 2A],
XPC [auth 2A],
XQ [auth 1A],
XQA [auth 1A],
XQB [auth 2A],
XQC [auth 2A],
XR [auth 1A],
XRA [auth 1A],
XRB [auth 2A],
XRC [auth 2B],
XS [auth 1A],
XSA [auth 1B],
XSB [auth 2A],
XSC [auth 2O],
XT [auth 1A],
XTA [auth 1H],
XTB [auth 2A],
XTC [auth 20],
XU [auth 1A],
XUA [auth 1U],
XUB [auth 2A],
XUC [auth 2a],
XV [auth 1A],
XVA [auth 17],
XVB [auth 2A],
XVC [auth 2a],
XW [auth 1A],
XWA [auth 1a],
XWB [auth 2A],
XWC [auth 2a],
XX [auth 1A],
XXA [auth 1a],
XXB [auth 2A],
XXC [auth 2a],
XY [auth 1A],
XYA [auth 1a],
XYB [auth 2A],
XYC [auth 2a],
XZ [auth 1A],
XZA [auth 1a],
XZB [auth 2A],
XZC [auth 2a],
YAA [auth 1A],
YAB [auth 1a],
YAC [auth 2A],
YAD [auth 2a],
YBA [auth 1A],
YBB [auth 1a],
YBC [auth 2A],
YBD [auth 2a],
YCA [auth 1A],
YCB [auth 1a],
YCC [auth 2A],
YCD [auth 2a],
YD [auth 1A],
YDA [auth 1A],
YDB [auth 1a],
YDC [auth 2A],
YDD [auth 2a],
YE [auth 1A],
YEA [auth 1A],
YEB [auth 1a],
YEC [auth 2A],
YED [auth 2a],
YF [auth 1A],
YFA [auth 1A],
YFB [auth 1a],
YFC [auth 2A],
YFD [auth 2a],
YG [auth 1A],
YGA [auth 1A],
YGB [auth 1a],
YGC [auth 2A],
YGD [auth 2a],
YH [auth 1A],
YHA [auth 1A],
YHB [auth 1a],
YHC [auth 2A],
YHD [auth 2g],
YI [auth 1A],
YIA [auth 1A],
YIB [auth 1d],
YIC [auth 2A],
YID [auth 2q],
YJ [auth 1A],
YJA [auth 1A],
YJB [auth 1y],
YJC [auth 2A],
YJD [auth 2x],
YK [auth 1A],
YKA [auth 1A],
YKB [auth 2A],
YKC [auth 2A],
YL [auth 1A],
YLA [auth 1A],
YLB [auth 2A],
YLC [auth 2A],
YM [auth 1A],
YMA [auth 1A],
YMB [auth 2A],
YMC [auth 2A],
YN [auth 1A],
YNA [auth 1A],
YNB [auth 2A],
YNC [auth 2A],
YO [auth 1A],
YOA [auth 1A],
YOB [auth 2A],
YOC [auth 2A],
YP [auth 1A],
YPA [auth 1A],
YPB [auth 2A],
YPC [auth 2A],
YQ [auth 1A],
YQA [auth 1A],
YQB [auth 2A],
YQC [auth 2A],
YR [auth 1A],
YRA [auth 1A],
YRB [auth 2A],
YRC [auth 2B],
YS [auth 1A],
YSA [auth 1B],
YSB [auth 2A],
YSC [auth 2P],
YT [auth 1A],
YTA [auth 1N],
YTB [auth 2A],
YTC [auth 20],
YU [auth 1A],
YUA [auth 1U],
YUB [auth 2A],
YUC [auth 2a],
YV [auth 1A],
YVA [auth 17],
YVB [auth 2A],
YVC [auth 2a],
YW [auth 1A],
YWA [auth 1a],
YWB [auth 2A],
YWC [auth 2a],
YX [auth 1A],
YXA [auth 1a],
YXB [auth 2A],
YXC [auth 2a],
YY [auth 1A],
YYA [auth 1a],
YYB [auth 2A],
YYC [auth 2a],
YZ [auth 1A],
YZA [auth 1a],
YZB [auth 2A],
YZC [auth 2a],
ZAA [auth 1A],
ZAB [auth 1a],
ZAC [auth 2A],
ZAD [auth 2a],
ZBA [auth 1A],
ZBB [auth 1a],
ZBC [auth 2A],
ZBD [auth 2a],
ZCA [auth 1A],
ZCB [auth 1a],
ZCC [auth 2A],
ZCD [auth 2a],
ZD [auth 1A],
ZDA [auth 1A],
ZDB [auth 1a],
ZDC [auth 2A],
ZDD [auth 2a],
ZE [auth 1A],
ZEA [auth 1A],
ZEB [auth 1a],
ZEC [auth 2A],
ZED [auth 2a],
ZF [auth 1A],
ZFA [auth 1A],
ZFB [auth 1a],
ZFC [auth 2A],
ZFD [auth 2a],
ZG [auth 1A],
ZGA [auth 1A],
ZGB [auth 1a],
ZGC [auth 2A],
ZGD [auth 2a],
ZH [auth 1A],
ZHA [auth 1A],
ZHB [auth 1a],
ZHC [auth 2A],
ZHD [auth 2h],
ZI [auth 1A],
ZIA [auth 1A],
ZIB [auth 1e],
ZIC [auth 2A],
ZID [auth 2q],
ZJ [auth 1A],
ZJA [auth 1A],
ZJB [auth 1y],
ZJC [auth 2A],
ZJD [auth 2y],
ZK [auth 1A],
ZKA [auth 1A],
ZKB [auth 2A],
ZKC [auth 2A],
ZL [auth 1A],
ZLA [auth 1A],
ZLB [auth 2A],
ZLC [auth 2A],
ZM [auth 1A],
ZMA [auth 1A],
ZMB [auth 2A],
ZMC [auth 2A],
ZN [auth 1A],
ZNA [auth 1A],
ZNB [auth 2A],
ZNC [auth 2A],
ZO [auth 1A],
ZOA [auth 1A],
ZOB [auth 2A],
ZOC [auth 2A],
ZP [auth 1A],
ZPA [auth 1A],
ZPB [auth 2A],
ZPC [auth 2A],
ZQ [auth 1A],
ZQA [auth 1A],
ZQB [auth 2A],
ZQC [auth 2A],
ZR [auth 1A],
ZRA [auth 1A],
ZRB [auth 2A],
ZRC [auth 2B],
ZS [auth 1A],
ZSA [auth 1B],
ZSB [auth 2A],
ZSC [auth 2P],
ZT [auth 1A],
ZTA [auth 1O],
ZTB [auth 2A],
ZTC [auth 21],
ZU [auth 1A],
ZUA [auth 1V],
ZUB [auth 2A],
ZUC [auth 2a],
ZV [auth 1A],
ZVA [auth 18],
ZVB [auth 2A],
ZVC [auth 2a],
ZW [auth 1A],
ZWA [auth 1a],
ZWB [auth 2A],
ZWC [auth 2a],
ZX [auth 1A],
ZXA [auth 1a],
ZXB [auth 2A],
ZXC [auth 2a],
ZY [auth 1A],
ZYA [auth 1a],
ZYB [auth 2A],
ZYC [auth 2a],
ZZ [auth 1A],
ZZA [auth 1a],
ZZB [auth 2A],
ZZC [auth 2a]
MAGNESIUM ION
Mg
JLVVSXFLKOJNIY-UHFFFAOYSA-N
Modified Residues  1 Unique
IDChains TypeFormula2D DiagramParent
0TD
Query on 0TD
PA [auth 1l],
TC [auth 2l]
L-PEPTIDE LINKINGC5 H9 N O4 SASP
Experimental Data & Validation

Experimental Data

  • Method: X-RAY DIFFRACTION
  • Resolution: 3.50 Å
  • R-Value Free: 0.294 
  • R-Value Work: 0.244 
  • R-Value Observed: 0.246 
  • Space Group: P 21 21 21
Unit Cell:
Length ( Å )Angle ( ˚ )
a = 209.655α = 90
b = 448.741β = 90
c = 623.994γ = 90
Software Package:
Software NamePurpose
PHENIXrefinement
XDSdata reduction
XSCALEdata scaling
Cootmodel building
PDB_EXTRACTdata extraction
PHASERphasing

Structure Validation

View Full Validation Report



Ligand Structure Quality Assessment 


Entry History & Funding Information

Deposition Data


Funding OrganizationLocationGrant Number
Ministry of Science and Technology (MoST, China)China2017YFA0504602
National Natural Science Foundation of China (NSFC)China31770784
Other privateUnited StatesStartup funds from The University of Texas Medical Branch
Other privateUnited StatesRising Science and Technology Acquisition and Retention Program award
Other privateUnited StatesMcLaughlin Fellowship from the Institute for Human Infections and Immunity at The University of Texas Medical Branch
Other privateUnited StatesEndowment from Sealy and Smith Foundation to Sealy Center for Structural Biology at The University of Texas Medical Branch

Revision History  (Full details and data files)

  • Version 1.0: 2019-12-25
    Type: Initial release
  • Version 1.1: 2020-01-08
    Changes: Database references
  • Version 1.2: 2020-01-22
    Changes: Database references
  • Version 1.3: 2023-10-11
    Changes: Data collection, Database references, Derived calculations, Refinement description
  • Version 1.4: 2023-11-15
    Changes: Data collection