6TXO
Crystal structure of the haemagglutinin mutant (Gln226Leu, Del228) from an H10N7 seal influenza virus isolated in Germany in complex with avian receptor analogue 3'-SLN
- PDB DOI: https://doi.org/10.2210/pdb6TXO/pdb
- Classification: VIRAL PROTEIN
- Organism(s): Influenza A virus (A/harbour seal/Germany/1/2014(H10N7))
- Expression System: unidentified baculovirus
- Mutation(s): No
- Deposited: 2020-01-14 Released: 2020-10-21
- Funding Organization(s): The Francis Crick Institute
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 2.40 Å
- R-Value Free: 0.271
- R-Value Work: 0.249
- R-Value Observed: 0.250
This is version 1.1 of the entry. See complete history.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Hemagglutinin HA2 | A [auth B], B [auth D], C [auth F] | 177 | Influenza A virus (A/harbour seal/Germany/1/2014(H10N7)) | Mutation(s): 0 Gene Names: HA |  |
UniProt | |||||
Find proteins for A0A0A7HR51 (Influenza A virus) Explore A0A0A7HR51 Go to UniProtKB: A0A0A7HR51 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | A0A0A7HR51 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 2 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Hemagglutinin | D [auth A], E [auth C], F [auth E] | 324 | Influenza A virus (A/harbour seal/Germany/1/2014(H10N7)) | Mutation(s): 0 Gene Names: HA |  |
UniProt | |||||
Find proteins for A0A0A7HR51 (Influenza A virus) Explore A0A0A7HR51 Go to UniProtKB: A0A0A7HR51 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | A0A0A7HR51 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Oligosaccharides
Small Molecules
| Ligands 4 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| SIA (Subject of Investigation/LOI) Query on SIA | N [auth E] | N-acetyl-alpha-neuraminic acid C11 H19 N O9 SQVRNKJHWKZAKO-YRMXFSIDSA-N |  | ||
| NAG Query on NAG | K [auth D], L [auth F] | 2-acetamido-2-deoxy-beta-D-glucopyranose C8 H15 N O6 OVRNDRQMDRJTHS-FMDGEEDCSA-N |  | ||
| EDO Query on EDO | J [auth B] | 1,2-ETHANEDIOL C2 H6 O2 LYCAIKOWRPUZTN-UHFFFAOYSA-N |  | ||
| CA Query on CA | M [auth C] | CALCIUM ION Ca BHPQYMZQTOCNFJ-UHFFFAOYSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 2.40 Å
- R-Value Free: 0.271
- R-Value Work: 0.249
- R-Value Observed: 0.250
- Space Group: P 1 21 1
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 69.872 | α = 90 |
| b = 211.996 | β = 105.03 |
| c = 82.479 | γ = 90 |
| Software Name | Purpose |
|---|---|
| REFMAC | refinement |
| PDB_EXTRACT | data extraction |
| Aimless | data reduction |
| xia2 | data scaling |
| PHASER | phasing |
Entry History & Funding Information
Deposition Data
- Released Date: 2020-10-21 Deposition Author(s): Zhang, J., Xiong, X., Purkiss, A., Walker, P., Gamblin, S., Skehel, J.J.
| Funding Organization | Location | Grant Number |
|---|---|---|
| The Francis Crick Institute | United Kingdom | -- |
Revision History (Full details and data files)
- Version 1.0: 2020-10-21
Type: Initial release - Version 1.1: 2024-01-24
Changes: Data collection, Database references, Refinement description
