6S5A
CRYSTAL STRUCTURE OF FC P329G LALA WITH ANTI FC P329G FAB
- PDB DOI: https://doi.org/10.2210/pdb6S5A/pdb
- Classification: IMMUNE SYSTEM
- Organism(s): Homo sapiens, Mus musculus
- Expression System: Cricetulus griseus
- Mutation(s): No
- Deposited: 2019-07-01 Released: 2019-09-25
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 1.72 Å
- R-Value Free: 0.226
- R-Value Work: 0.196
- R-Value Observed: 0.197
wwPDB Validation 3D Report Full Report
This is version 2.0 of the entry. See complete history.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Fc P329G LALA | A, B [auth D] | 225 | Homo sapiens | Mutation(s): 0 |  |
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
Sequence AnnotationsExpand | |||||
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Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 2 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| anti P329G LALA Fab heavy chain | C [auth H] | 251 | Mus musculus | Mutation(s): 0 |  |
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
Sequence AnnotationsExpand | |||||
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Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 3 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| anti P329G LALA Fab light chain | D [auth L] | 215 | Mus musculus | Mutation(s): 0 |  |
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
Sequence AnnotationsExpand | |||||
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Oligosaccharides
Entity ID: 4 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Length | 2D Diagram | Glycosylation | 3D Interactions |
| 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | E [auth B] | 6 |  | N-Glycosylation | |
Glycosylation Resources | |||||
GlyTouCan: G39203UC GlyCosmos: G39203UC GlyGen: G39203UC | |||||
Entity ID: 5 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Length | 2D Diagram | Glycosylation | 3D Interactions |
| 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | F [auth C] | 7 |  | N-Glycosylation | |
Glycosylation Resources | |||||
GlyTouCan: G45889JQ GlyCosmos: G45889JQ GlyGen: G45889JQ | |||||
Small Molecules
| Ligands 2 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| PO4 Query on PO4 | G [auth D], J [auth L], K [auth L] | PHOSPHATE ION O4 P NBIIXXVUZAFLBC-UHFFFAOYSA-K |  | ||
| GOL Query on GOL | H [auth D], I [auth H], L | GLYCEROL C3 H8 O3 PEDCQBHIVMGVHV-UHFFFAOYSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 1.72 Å
- R-Value Free: 0.226
- R-Value Work: 0.196
- R-Value Observed: 0.197
- Space Group: P 21 21 21
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 71.022 | α = 90 |
| b = 135.545 | β = 90 |
| c = 137.259 | γ = 90 |
| Software Name | Purpose |
|---|---|
| BUSTER | refinement |
| PDB_EXTRACT | data extraction |
| XDS | data reduction |
| SADABS | data scaling |
| PHASER | phasing |
Entry History
Deposition Data
- Released Date: 2019-09-25 Deposition Author(s): Ehler, A., Darowski, D., Jost, C., Stubenrauch, K., Wessels, U., Benz, J., Birk, M., Freimoser-Grundschober, A., Bruenker, P., Moessner, E., Umana, P., Kobold, S., Klein, C.
Revision History (Full details and data files)
- Version 1.0: 2019-09-25
Type: Initial release - Version 1.1: 2020-02-26
Changes: Data collection, Database references - Version 2.0: 2020-07-29
Type: Remediation
Reason: Carbohydrate remediation
Changes: Atomic model, Data collection, Derived calculations, Structure summary
