6HXW
structure of human CD73 in complex with antibody IPH53
- PDB DOI: https://doi.org/10.2210/pdb6HXW/pdb
- Classification: IMMUNE SYSTEM
- Organism(s): Homo sapiens, synthetic construct
- Expression System: Cricetulus griseus
- Mutation(s): No
- Deposited: 2018-10-18 Released: 2019-08-28
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 2.78 Å
- R-Value Free: 0.232
- R-Value Work: 0.192
- R-Value Observed: 0.194
This is version 1.1 of the entry. See complete history.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| 5'-nucleotidase | 527 | Homo sapiens | Mutation(s): 0 Gene Names: NT5E, NT5, NTE EC: 3.1.3.5 |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P21589 (Homo sapiens) Explore P21589 Go to UniProtKB: P21589 | |||||
PHAROS: P21589 GTEx: ENSG00000135318 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P21589 | ||||
Sequence AnnotationsExpand | |||||
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Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 2 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| IPH53 heavy chain | C, E [auth H] | 231 | synthetic construct | Mutation(s): 0 |  |
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
Sequence AnnotationsExpand | |||||
| |||||
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 3 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| IPH53 light chain | D, F [auth L] | 209 | synthetic construct | Mutation(s): 0 |  |
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
Sequence AnnotationsExpand | |||||
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Small Molecules
| Ligands 2 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| NAG Query on NAG | G [auth A], J [auth B] | 2-acetamido-2-deoxy-beta-D-glucopyranose C8 H15 N O6 OVRNDRQMDRJTHS-FMDGEEDCSA-N |  | ||
| ZN Query on ZN | H [auth A], I [auth A], K [auth B], L [auth B] | ZINC ION Zn PTFCDOFLOPIGGS-UHFFFAOYSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 2.78 Å
- R-Value Free: 0.232
- R-Value Work: 0.192
- R-Value Observed: 0.194
- Space Group: P 21 21 2
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 195.347 | α = 90 |
| b = 209.429 | β = 90 |
| c = 65.065 | γ = 90 |
| Software Name | Purpose |
|---|---|
| BUSTER | refinement |
| XDS | data reduction |
| SCALA | data scaling |
| MOLREP | phasing |
| PDB_EXTRACT | data extraction |
Entry History
Deposition Data
- Released Date: 2019-08-28 Deposition Author(s): Roussel, A., Amigues, B.
Revision History (Full details and data files)
- Version 1.0: 2019-08-28
Type: Initial release - Version 1.1: 2020-07-29
Type: Remediation
Reason: Carbohydrate remediation
Changes: Data collection, Derived calculations, Structure summary
