6E56
Human antibody H2214 in complex with influenza hemagglutinin A/Aichi/2/1968 (X-31) (H3N2)
- PDB DOI: https://doi.org/10.2210/pdb6E56/pdb
- Classification: VIRAL PROTEIN/IMMUNE SYSTEM
- Organism(s): Influenza A virus (A/Aichi/2/1968(H3N2)), Homo sapiens
- Expression System: Trichoplusia ni, Homo sapiens
- Mutation(s): No 
- Deposited: 2018-07-19 Released: 2019-05-22 
- Funding Organization(s): National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 2.00 Å
- R-Value Free: 0.214 
- R-Value Work: 0.188 
- R-Value Observed: 0.189 
wwPDB Validation   3D Report Full Report
This is version 2.1 of the entry. See complete history. 
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
---|---|---|---|---|---|
Molecule | Chains | Sequence Length | Organism | Details | Image |
Hemagglutinin | A [auth D], B [auth A] | 290 | Influenza A virus (A/Aichi/2/1968(H3N2)) | Mutation(s): 0  Gene Names: HA | |
UniProt | |||||
Find proteins for P03437 (Influenza A virus (strain A/Aichi/2/1968 H3N2)) Explore P03437  Go to UniProtKB:  P03437 | |||||
Entity Groups   | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
UniProt Group | P03437 | ||||
Sequence AnnotationsExpand | |||||
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Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 2 | |||||
---|---|---|---|---|---|
Molecule | Chains | Sequence Length | Organism | Details | Image |
antibody H2214 heavy chain | C [auth H], D [auth G] | 253 | Homo sapiens | Mutation(s): 0  Gene Names: IGHV3-23*01 | |
Entity Groups   | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
Sequence AnnotationsExpand | |||||
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Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 3 | |||||
---|---|---|---|---|---|
Molecule | Chains | Sequence Length | Organism | Details | Image |
antibody H2214 light chain, K1642 | E [auth I], F [auth J] | 215 | Homo sapiens | Mutation(s): 0  Gene Names: IGKV3-15*01 | |
UniProt | |||||
Find proteins for Q6PIL8 (Homo sapiens) Explore Q6PIL8  Go to UniProtKB:  Q6PIL8 | |||||
Entity Groups   | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
UniProt Group | Q6PIL8 | ||||
Sequence AnnotationsExpand | |||||
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Oligosaccharides
Small Molecules
Ligands 2 Unique | |||||
---|---|---|---|---|---|
ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
NAG Query on NAG | H [auth D], J [auth A] | 2-acetamido-2-deoxy-beta-D-glucopyranose C8 H15 N O6 OVRNDRQMDRJTHS-FMDGEEDCSA-N | |||
ACT Query on ACT | I [auth D], K [auth A] | ACETATE ION C2 H3 O2 QTBSBXVTEAMEQO-UHFFFAOYSA-M |
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 2.00 Å
- R-Value Free: 0.214 
- R-Value Work: 0.188 
- R-Value Observed: 0.189 
- Space Group: P 21 2 21
Unit Cell:
Length ( Å ) | Angle ( ˚ ) |
---|---|
a = 77.55 | α = 90 |
b = 98.71 | β = 90 |
c = 224.87 | γ = 90 |
Software Name | Purpose |
---|---|
PHENIX | refinement |
XDS | data reduction |
XSCALE | data scaling |
PHASER | phasing |
Entry History & Funding Information
Deposition Data
- Released Date: 2019-05-22  Deposition Author(s): McCarthy, K.R., Harrison, S.C.
Funding Organization | Location | Grant Number |
---|---|---|
National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) | United States | P01AI089618 |
National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) | United States | 1U19AI117892-01 |
National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) | United States | AI128832 |
Revision History (Full details and data files)
- Version 1.0: 2019-05-22
Type: Initial release - Version 1.1: 2019-05-29
Changes: Data collection, Database references - Version 1.2: 2019-12-18
Changes: Author supporting evidence - Version 2.0: 2020-07-29
Type: Remediation
Reason: Carbohydrate remediation
Changes: Atomic model, Data collection, Derived calculations, Structure summary - Version 2.1: 2023-10-11
Changes: Data collection, Database references, Refinement description, Structure summary