6A4K
Human antibody 32D6 Fab in complex with H1N1 influenza A virus HA1
- PDB DOI: https://doi.org/10.2210/pdb6A4K/pdb
- Classification: VIRAL PROTEIN/IMMUNE SYSTEM
- Organism(s): Influenza A virus (A/California/7/2009(H1N1)), Homo sapiens
- Expression System: Homo sapiens
- Mutation(s): No
- Deposited: 2018-06-20 Released: 2019-03-27
- Funding Organization(s): Academia Sinica (Taiwan)
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 3.15 Å
- R-Value Free: 0.233
- R-Value Work: 0.175
- R-Value Observed: 0.178
This is version 1.2 of the entry. See complete history.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Hemagglutinin | A, D [auth B], G [auth C], J [auth D] | 235 | Influenza A virus (A/California/7/2009(H1N1)) | Mutation(s): 0 |  |
UniProt | |||||
Find proteins for C3W5X2 (Influenza A virus) Explore C3W5X2 Go to UniProtKB: C3W5X2 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | C3W5X2 | ||||
Sequence AnnotationsExpand | |||||
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Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 2 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| immunoglobulin Fab heavy chain | B [auth H], E [auth I], H [auth J], K | 238 | Homo sapiens | Mutation(s): 0 |  |
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
Sequence AnnotationsExpand | |||||
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Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 3 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| immunoglobulin Fab light chain | C [auth L], F [auth M], I [auth N], L [auth O] | 216 | Homo sapiens | Mutation(s): 0 |  |
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
Sequence AnnotationsExpand | |||||
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Small Molecules
| Ligands 3 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| NAG Query on NAG | M [auth A], O [auth B], R [auth C], T [auth D] | 2-acetamido-2-deoxy-beta-D-glucopyranose C8 H15 N O6 OVRNDRQMDRJTHS-FMDGEEDCSA-N |  | ||
| ACT Query on ACT | Q [auth B], V [auth D] | ACETATE ION C2 H3 O2 QTBSBXVTEAMEQO-UHFFFAOYSA-M |  | ||
| CA Query on CA | N [auth A], P [auth B], S [auth C], U [auth D], W [auth O] | CALCIUM ION Ca BHPQYMZQTOCNFJ-UHFFFAOYSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 3.15 Å
- R-Value Free: 0.233
- R-Value Work: 0.175
- R-Value Observed: 0.178
- Space Group: P 31 1 2
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 181.743 | α = 90 |
| b = 181.743 | β = 90 |
| c = 248.091 | γ = 120 |
| Software Name | Purpose |
|---|---|
| REFMAC | refinement |
| HKL-2000 | data reduction |
| HKL-2000 | data scaling |
| PHASER | phasing |
Entry History & Funding Information
Deposition Data
- Released Date: 2019-03-27 Deposition Author(s): Lee, C.C., Ko, T.P., Lin, L.L., Wang, A.H.J.
| Funding Organization | Location | Grant Number |
|---|---|---|
| Academia Sinica (Taiwan) | Taiwan | -- |
Revision History (Full details and data files)
- Version 1.0: 2019-03-27
Type: Initial release - Version 1.1: 2020-07-29
Type: Remediation
Reason: Carbohydrate remediation
Changes: Data collection, Derived calculations, Structure summary - Version 1.2: 2023-11-22
Changes: Data collection, Database references, Refinement description, Structure summary
