5WFN

Revised model of leiomodin 2-mediated actin regulation (alternate refinement of PDB 4RWT)


Experimental Data Snapshot

  • Method: X-RAY DIFFRACTION
  • Resolution: 3.00 Å
  • R-Value Free: 0.246 
  • R-Value Work: 0.208 
  • R-Value Observed: 0.210 

wwPDB Validation   3D Report Full Report


Ligand Structure Quality Assessment 


This is version 1.6 of the entry. See complete history

Re-refinement Note

This entry reflects an alternative modeling of the original data in: 4RWT


Literature

Crystal structure of leiomodin 2 in complex with actin: a structural and functional reexamination

Boczkowska, M.Yurtsever, Z.Rebowski, G.Eck, M.J.Dominguez, R.

(2017) Biophys J 113: 889-899


Macromolecules
Find similar proteins by:  (by identity cutoff)  |  3D Structure
Entity ID: 1
MoleculeChains Sequence LengthOrganismDetailsImage
Actin-5CA,
C [auth B]
384Drosophila melanogasterMutation(s): 2 
Gene Names: Act5CCG4027
UniProt
Find proteins for P10987 (Drosophila melanogaster)
Explore P10987 
Go to UniProtKB:  P10987
Entity Groups  
Sequence Clusters30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity
UniProt GroupP10987
Sequence Annotations
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  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  3D Structure
Entity ID: 2
MoleculeChains Sequence LengthOrganismDetailsImage
Leiomodin-2B [auth C],
D
506Homo sapiensMutation(s): 8 
Gene Names: LMOD2
UniProt & NIH Common Fund Data Resources
Find proteins for Q6P5Q4 (Homo sapiens)
Explore Q6P5Q4 
Go to UniProtKB:  Q6P5Q4
PHAROS:  Q6P5Q4
GTEx:  ENSG00000170807 
Entity Groups  
Sequence Clusters30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity
UniProt GroupQ6P5Q4
Sequence Annotations
Expand
  • Reference Sequence
Experimental Data & Validation

Experimental Data

  • Method: X-RAY DIFFRACTION
  • Resolution: 3.00 Å
  • R-Value Free: 0.246 
  • R-Value Work: 0.208 
  • R-Value Observed: 0.210 
  • Space Group: P 1
Unit Cell:
Length ( Å )Angle ( ˚ )
a = 65.35α = 101.29
b = 65.65β = 90.94
c = 81.92γ = 107.97
Software Package:
Software NamePurpose
PHENIXrefinement

Structure Validation

View Full Validation Report



Ligand Structure Quality Assessment 


Entry History & Funding Information

Deposition Data


Funding OrganizationLocationGrant Number
National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)United StatesR01 GM073791
National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)United StatesR01 GM110352

Revision History  (Full details and data files)

  • Version 1.0: 2017-08-30
    Type: Initial release
  • Version 1.1: 2017-09-27
    Changes: Author supporting evidence
  • Version 1.2: 2018-01-31
    Changes: Database references
  • Version 1.3: 2018-08-22
    Changes: Data collection, Database references
  • Version 1.4: 2020-01-01
    Changes: Author supporting evidence
  • Version 1.5: 2020-09-23
    Changes: Database references, Derived calculations
  • Version 1.6: 2024-03-13
    Changes: Data collection, Database references