Insulin with proline analog DhP at position B28 in the R6 state
Lieblich, S.A., Fang, K.Y., Tirrell, D.A.To be published.
Experimental Data Snapshot
wwPDB Validation   3D Report Full Report
Find similar proteins by: Sequence | 3D Structure
Entity ID: 1 | |||||
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Molecule | Chains | Sequence Length | Organism | Details | Image |
Insulin Chain A | 21 | Homo sapiens | Mutation(s): 0  Gene Names: INS | ||
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P01308 (Homo sapiens) Explore P01308  Go to UniProtKB:  P01308 | |||||
PHAROS:  P01308 GTEx:  ENSG00000254647  | |||||
Entity Groups   | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
UniProt Group | P01308 | ||||
Sequence AnnotationsExpand | |||||
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Entity ID: 2 | |||||
---|---|---|---|---|---|
Molecule | Chains | Sequence Length | Organism | Details | Image |
Insulin Chain B | 30 | Homo sapiens | Mutation(s): 0  Gene Names: INS | ||
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P01308 (Homo sapiens) Explore P01308  Go to UniProtKB:  P01308 | |||||
PHAROS:  P01308 GTEx:  ENSG00000254647  | |||||
Entity Groups   | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
UniProt Group | P01308 | ||||
Sequence AnnotationsExpand | |||||
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Ligands 3 Unique | |||||
---|---|---|---|---|---|
ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
IPH Query on IPH | I [auth A], L [auth C], O [auth E], R [auth G] | PHENOL C6 H6 O ISWSIDIOOBJBQZ-UHFFFAOYSA-N | |||
ZN Query on ZN | J [auth B], M [auth D], P [auth F], S [auth H] | ZINC ION Zn PTFCDOFLOPIGGS-UHFFFAOYSA-N | |||
CL Query on CL | K [auth B], N [auth D], Q [auth F], T [auth H] | CHLORIDE ION Cl VEXZGXHMUGYJMC-UHFFFAOYSA-M |
Modified Residues 1 Unique | |||||
---|---|---|---|---|---|
ID | Chains | Type | Formula | 2D Diagram | Parent |
8LJ Query on 8LJ | B, D, F, H | L-PEPTIDE LINKING | C5 H7 N O2 | PRO |
Length ( Å ) | Angle ( ˚ ) |
---|---|
a = 79.259 | α = 90 |
b = 79.259 | β = 90 |
c = 79.874 | γ = 120 |
Software Name | Purpose |
---|---|
REFMAC | refinement |
Aimless | data scaling |
PHASER | phasing |
PDB_EXTRACT | data extraction |
Funding Organization | Location | Grant Number |
---|---|---|
Novo Nordisk Foundation | Denmark | -- |