Download MendeleyStructure of Maternal Embryonic Leucine Zipper Kinase
Seo, H.-Y., Dhe-Paganon, S.To be published.
5TVT
Structure of Maternal Embryonic Leucine Zipper Kinase
- PDB DOI: https://doi.org/10.2210/pdb5TVT/pdb
- Classification: Transferase/Transferase Inhibitor
- Organism(s): Homo sapiens
- Expression System: Escherichia coli
- Mutation(s): No
- Deposited: 2016-11-10 Released: 2017-11-15
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 2.28 Å
- R-Value Free: 0.229
- R-Value Work: 0.190
- R-Value Observed: 0.192
This is version 1.1 of the entry. See complete history.
Literature
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Maternal embryonic leucine zipper kinase | 334 | Homo sapiens | Mutation(s): 0 Gene Names: MELK, KIAA0175 EC: 2.7.11.1 (PDB Primary Data), 2.7.10.2 (PDB Primary Data) |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for Q14680 (Homo sapiens) Explore Q14680 Go to UniProtKB: Q14680 | |||||
PHAROS: Q14680 GTEx: ENSG00000165304 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | Q14680 | ||||
Sequence AnnotationsExpand | |||||
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Small Molecules
| Ligands 1 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| 7LV Query on 7LV | B [auth A] | 9-(3,5-dichloro-4-hydroxyphenyl)-1-{trans-4-[(dimethylamino)methyl]cyclohexyl}-3-methyl-3,4-dihydropyrimido[5,4-c][1,5]naphthyridin-2(1H)-one C26 H29 Cl2 N5 O2 HHDFQGMZNYJMHI-RZDIXWSQSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 2.28 Å
- R-Value Free: 0.229
- R-Value Work: 0.190
- R-Value Observed: 0.192
- Space Group: P 21 21 21
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 56.69 | α = 90 |
| b = 68.65 | β = 90 |
| c = 105.04 | γ = 90 |
| Software Name | Purpose |
|---|---|
| PHENIX | refinement |
| XDS | data reduction |
| Aimless | data scaling |
| PHENIX | phasing |
Entry History
Deposition Data
- Released Date: 2017-11-15 Deposition Author(s): Seo, H.-Y., Huang, H., Gray, N.S., Dhe-Paganon, S.
Revision History (Full details and data files)
- Version 1.0: 2017-11-15
Type: Initial release - Version 1.1: 2024-03-06
Changes: Data collection, Database references
