Download MendeleyHuman METTL3-METTL14 complex
ZENG, H., DONG, A., LI, Y., TEMPEL, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., BROWN, P.J., WU, H., Structural Genomics Consortium (SGC)To be published.
5TEY
Human METTL3-METTL14 complex
- PDB DOI: https://doi.org/10.2210/pdb5TEY/pdb
- Classification: TRANSFERASE
- Organism(s): Homo sapiens
- Expression System: Spodoptera frugiperda
- Mutation(s): No
- Deposited: 2016-09-23 Released: 2016-11-23
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 1.80 Å
- R-Value Free: 0.224
- R-Value Work: 0.198
- R-Value Observed: 0.198
This is version 1.2 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| N6-adenosine-methyltransferase 70 kDa subunit | 598 | Homo sapiens | Mutation(s): 0 Gene Names: METTL3, MTA70 EC: 2.1.1.62 |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for Q86U44 (Homo sapiens) Explore Q86U44 Go to UniProtKB: Q86U44 | |||||
PHAROS: Q86U44 GTEx: ENSG00000165819 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | Q86U44 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 2 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| N6-adenosine-methyltransferase subunit METTL14 | 399 | Homo sapiens | Mutation(s): 0 Gene Names: METTL14, KIAA1627 EC: 2.1.1.62 |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for Q9HCE5 (Homo sapiens) Explore Q9HCE5 Go to UniProtKB: Q9HCE5 | |||||
PHAROS: Q9HCE5 GTEx: ENSG00000145388 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | Q9HCE5 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 5 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| SAH Query on SAH | C [auth A] | S-ADENOSYL-L-HOMOCYSTEINE C14 H20 N6 O5 S ZJUKTBDSGOFHSH-WFMPWKQPSA-N |  | ||
| BME Query on BME | H [auth B] | BETA-MERCAPTOETHANOL C2 H6 O S DGVVWUTYPXICAM-UHFFFAOYSA-N |  | ||
| EDO Query on EDO | E [auth A] | 1,2-ETHANEDIOL C2 H6 O2 LYCAIKOWRPUZTN-UHFFFAOYSA-N |  | ||
| MG Query on MG | D [auth A] | MAGNESIUM ION Mg JLVVSXFLKOJNIY-UHFFFAOYSA-N |  | ||
| UNX Query on UNX | F [auth A] G [auth A] I [auth B] J [auth B] K [auth B] | UNKNOWN ATOM OR ION X |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 1.80 Å
- R-Value Free: 0.224
- R-Value Work: 0.198
- R-Value Observed: 0.198
- Space Group: P 32 2 1
- Diffraction Data: https://doi.org/10.18430/M35TEY
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 63.883 | α = 90 |
| b = 63.883 | β = 90 |
| c = 225.709 | γ = 120 |
| Software Name | Purpose |
|---|---|
| SCALEPACK | data scaling |
| REFMAC | refinement |
| PDB_EXTRACT | data extraction |
| PHASER | phasing |
| HKL-3000 | data reduction |
Entry History
Deposition Data
- Released Date: 2016-11-23 Deposition Author(s): DONG, A., ZENG, H., LI, Y., TEMPEL, W., Seitova, A., Hutchinson, A., Bountra, C., Arrowsmith, C.H., Edwards, A.M., BROWN, P.J., WU, H., Structural Genomics Consortium (SGC)
Revision History (Full details and data files)
- Version 1.0: 2016-11-23
Type: Initial release - Version 1.1: 2018-01-24
Changes: Structure summary - Version 1.2: 2023-10-04
Changes: Data collection, Database references, Refinement description
