Download MendeleyCrystal Structure of a Factor VIIa complex
Mayweg, A., Roever, S., Rudolph, M.G.To be published.
5PAT
Crystal Structure of Factor VIIa in complex with N-(2-amino-1H-benzimidazol-5-yl)-2-(3-chlorophenyl)acetamide
- PDB DOI: https://doi.org/10.2210/pdb5PAT/pdb
- Deposition Group: G_1002015 ExploreG_1002015
- Classification: HYDROLASE/HYDROLASE INHIBITOR
- Organism(s): Homo sapiens
- Expression System: Escherichia coli
- Mutation(s): No
- Deposited: 2016-11-10 Released: 2017-06-21
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 1.60 Å
- R-Value Free: 0.217
- R-Value Work: 0.186
- R-Value Observed: 0.187
This is version 1.3 of the entry. See complete history.
Literature
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Coagulation factor VII light chain | 64 | Homo sapiens | Mutation(s): 0 Gene Names: F7 EC: 3.4.21.21 |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P08709 (Homo sapiens) Explore P08709 Go to UniProtKB: P08709 | |||||
PHAROS: P08709 GTEx: ENSG00000057593 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P08709 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 2 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Coagulation factor VII heavy chain | 254 | Homo sapiens | Mutation(s): 0 Gene Names: F7 EC: 3.4.21.21 |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P08709 (Homo sapiens) Explore P08709 Go to UniProtKB: P08709 | |||||
PHAROS: P08709 GTEx: ENSG00000057593 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P08709 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 2 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| 7ZG Query on 7ZG | C [auth B] | N-(2-amino-1H-benzimidazol-5-yl)-2-(3-chlorophenyl)acetamide C15 H13 Cl N4 O HFZZWILRMJMUJK-UHFFFAOYSA-N |  | ||
| SO4 Query on SO4 | D [auth B], E [auth B] | SULFATE ION O4 S QAOWNCQODCNURD-UHFFFAOYSA-L |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 1.60 Å
- R-Value Free: 0.217
- R-Value Work: 0.186
- R-Value Observed: 0.187
- Space Group: P 41 21 2
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 95.16 | α = 90 |
| b = 95.16 | β = 90 |
| c = 116.13 | γ = 90 |
| Software Name | Purpose |
|---|---|
| XSCALE | data scaling |
| REFMAC | refinement |
| PDB_EXTRACT | data extraction |
| XDS | data reduction |
| PHASER | phasing |
Entry History
Deposition Data
- Released Date: 2017-06-21 Deposition Author(s): Stihle, M., Mayweg, A., Roever, S., Rudolph, M.G.
Revision History (Full details and data files)
- Version 1.0: 2017-06-21
Type: Initial release - Version 1.1: 2018-02-21
Changes: Structure summary - Version 1.2: 2021-11-17
Changes: Database references, Structure summary - Version 1.3: 2024-04-03
Changes: Data collection, Refinement description
