Helicobacter pylori antigenic Lpp20 is a structural homologue of Tip alpha and promotes epithelial-mesenchymal transition.
Vallese, F., Mishra, N.M., Pagliari, M., Berto, P., Codolo, G., de Bernard, M., Zanotti, G.(2017) Biochim Biophys Acta 1861: 3263-3271
- PubMed: 28947343 
- DOI: https://doi.org/10.1016/j.bbagen.2017.09.017
- Primary Citation of Related Structures:  
5OK8 - PubMed Abstract: 
Helicobacter pylori is a bacterium that affects about 50% of the world population and, despite being often asymptomatic, it is responsible of several gastric diseases, from gastritis to gastric cancer. The protein Lpp20 (HP1456) plays an important role in bacterium survival and host colonization, but the possibility that it might be involved in the etiology of H. pylori-related disorders is an unexplored issue. Lpp20 is a lipoprotein bound to the external membrane of the bacterium, but it is also secreted inside vesicles along with other two proteins of the same operon, i.e. HP1454 and HP1457.
Organizational Affiliation: 
Department of Biomedical Sciences, University of Padua, Via Ugo Bassi 58/B, Padua 35131, Italy.