5LDX

Structure of mammalian respiratory Complex I, class3.

PDB DOI: https://doi.org/10.2210/pdb5LDX/pdb
EM Map EMD-4041: EMDB EMDataResource

Classification: OXIDOREDUCTASE
Organism(s): Bos taurus
Mutation(s): No
Membrane Protein: Yes OPMPDBTMmpstruc

Deposited: 2016-06-28 Released: 2016-09-14
Deposition Author(s): Vinothkumar, K.R., Zhu, J., Hirst, J.
Funding Organization(s): Medical Research Council (United Kingdom)

Experimental Data Snapshot

Method: ELECTRON MICROSCOPY
Resolution: 5.60 Å
Aggregation State: PARTICLE
Reconstruction Method: SINGLE PARTICLE

wwPDB Validation 3D Report Full Report

This is version 1.3 of the entry. See complete history.

Literature

Structure of mammalian respiratory complex I.

Zhu, J., Vinothkumar, K.R., Hirst, J.

(2016) Nature 536: 354-358

PubMed: 27509854 Search on PubMedSearch on PubMed Central
DOI: https://doi.org/10.1038/nature19095
Primary Citation of Related Structures:
5LC5, 5LDW, 5LDX

PubMed Abstract:
Complex I (NADH:ubiquinone oxidoreductase), one of the largest membrane-bound enzymes in the cell, powers ATP synthesis in mammalian mitochondria by using the reducing potential of NADH to drive protons across the inner mitochondrial membrane. Mammalian complex I (ref. 1) contains 45 subunits, comprising 14 core subunits that house the catalytic machinery (and are conserved from bacteria to humans) and a mammalian-specific cohort of 31 supernumerary subunits. Knowledge of the structures and functions of the supernumerary subunits is fragmentary. Here we describe a 4.2-Å resolution single-particle electron cryomicroscopy structure of complex I from Bos taurus. We have located and modelled all 45 subunits, including the 31 supernumerary subunits, to provide the entire structure of the mammalian complex. Computational sorting of the particles identified different structural classes, related by subtle domain movements, which reveal conformationally dynamic regions and match biochemical descriptions of the 'active-to-de-active' enzyme transition that occurs during hypoxia. Our structures therefore provide a foundation for understanding complex I assembly and the effects of mutations that cause clinically relevant complex I dysfunctions, give insights into the structural and functional roles of the supernumerary subunits and reveal new information on the mechanism and regulation of catalysis.

Organizational Affiliation

MRC Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK.

Macromolecule Content

Total Structure Weight: 872.51 kDa
Atom Count: 51,181
Modelled Residue Count: 7,791
Deposited Residue Count: 8,105
Unique protein chains: 44

Macromolecules

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Entity ID: 1
Molecule	Chains	Sequence Length	Organism	Details	Image
NADH-ubiquinone oxidoreductase chain 3	A	115	Bos taurus	Mutation(s): 0 EC: 1.6.5.3 Membrane Entity: Yes
UniProt
Find proteins for P03898 (Bos taurus) Explore P03898 Go to UniProtKB: P03898
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Sequence Clusters	30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity
UniProt Group	P03898
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Reference Sequence

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Entity ID: 2
Molecule	Chains	Sequence Length	Organism	Details	Image
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	B	179	Bos taurus	Mutation(s): 0 EC: 1.6.5.3 (PDB Primary Data), 1.6.99.3 (PDB Primary Data) Membrane Entity: Yes
UniProt
Find proteins for P42026 (Bos taurus) Explore P42026 Go to UniProtKB: P42026
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Sequence Clusters	30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity
UniProt Group	P42026
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Entity ID: 3
Molecule	Chains	Sequence Length	Organism	Details	Image
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	C	228	Bos taurus	Mutation(s): 0 EC: 1.6.5.3 (PDB Primary Data), 1.6.99.3 (PDB Primary Data) Membrane Entity: Yes
UniProt
Find proteins for P23709 (Bos taurus) Explore P23709 Go to UniProtKB: P23709
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Sequence Clusters	30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity
UniProt Group	P23709
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Reference Sequence

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Entity ID: 4
Molecule	Chains	Sequence Length	Organism	Details	Image
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	D	429	Bos taurus	Mutation(s): 0 EC: 1.6.5.3 (PDB Primary Data), 1.6.99.3 (PDB Primary Data) Membrane Entity: Yes
UniProt
Find proteins for P17694 (Bos taurus) Explore P17694 Go to UniProtKB: P17694
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Sequence Clusters	30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity
UniProt Group	P17694
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Reference Sequence

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Entity ID: 5
Molecule	Chains	Sequence Length	Organism	Details	Image
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial	E	217	Bos taurus	Mutation(s): 0 EC: 1.6.5.3 (PDB Primary Data), 1.6.99.3 (PDB Primary Data) Membrane Entity: Yes
UniProt
Find proteins for P04394 (Bos taurus) Explore P04394 Go to UniProtKB: P04394
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UniProt Group	P04394
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Reference Sequence

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Entity ID: 6
Molecule	Chains	Sequence Length	Organism	Details	Image
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial	F	444	Bos taurus	Mutation(s): 0 EC: 1.6.5.3 (PDB Primary Data), 1.6.99.3 (PDB Primary Data) Membrane Entity: Yes
UniProt
Find proteins for P25708 (Bos taurus) Explore P25708 Go to UniProtKB: P25708
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UniProt Group	P25708
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Reference Sequence

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Entity ID: 7
Molecule	Chains	Sequence Length	Organism	Details	Image
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial	G	700	Bos taurus	Mutation(s): 0 EC: 1.6.5.3 (PDB Primary Data), 1.6.99.3 (PDB Primary Data) Membrane Entity: Yes
UniProt
Find proteins for P15690 (Bos taurus) Explore P15690 Go to UniProtKB: P15690
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UniProt Group	P15690
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Reference Sequence

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Entity ID: 8
Molecule	Chains	Sequence Length	Organism	Details	Image
NADH-ubiquinone oxidoreductase chain 1	H	318	Bos taurus	Mutation(s): 0 EC: 1.6.5.3 Membrane Entity: Yes
UniProt
Find proteins for P03887 (Bos taurus) Explore P03887 Go to UniProtKB: P03887
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UniProt Group	P03887
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Reference Sequence

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Entity ID: 9
Molecule	Chains	Sequence Length	Organism	Details	Image
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial	I	176	Bos taurus	Mutation(s): 0 EC: 1.6.5.3 (PDB Primary Data), 1.6.99.3 (PDB Primary Data) Membrane Entity: Yes
UniProt
Find proteins for P42028 (Bos taurus) Explore P42028 Go to UniProtKB: P42028
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Sequence Clusters	30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity
UniProt Group	P42028
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Entity ID: 10
Molecule	Chains	Sequence Length	Organism	Details	Image
NADH-ubiquinone oxidoreductase chain 6	J	175	Bos taurus	Mutation(s): 0 EC: 1.6.5.3 Membrane Entity: Yes
UniProt
Find proteins for P03924 (Bos taurus) Explore P03924 Go to UniProtKB: P03924
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Sequence Clusters	30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity
UniProt Group	P03924
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Reference Sequence

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Entity ID: 11
Molecule	Chains	Sequence Length	Organism	Details	Image
NADH-ubiquinone oxidoreductase chain 4L	K	98	Bos taurus	Mutation(s): 0 EC: 1.6.5.3 Membrane Entity: Yes
UniProt
Find proteins for P03902 (Bos taurus) Explore P03902 Go to UniProtKB: P03902
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Sequence Clusters	30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity
UniProt Group	P03902
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Entity ID: 12
Molecule	Chains	Sequence Length	Organism	Details	Image
NADH-ubiquinone oxidoreductase chain 5	L	606	Bos taurus	Mutation(s): 0 EC: 1.6.5.3 Membrane Entity: Yes
UniProt
Find proteins for P03920 (Bos taurus) Explore P03920 Go to UniProtKB: P03920
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UniProt Group	P03920
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Entity ID: 13
Molecule	Chains	Sequence Length	Organism	Details	Image
NADH-ubiquinone oxidoreductase chain 4	M	459	Bos taurus	Mutation(s): 0 EC: 1.6.5.3 Membrane Entity: Yes
UniProt
Find proteins for P03910 (Bos taurus) Explore P03910 Go to UniProtKB: P03910
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UniProt Group	P03910
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Entity ID: 14
Molecule	Chains	Sequence Length	Organism	Details	Image
NADH-ubiquinone oxidoreductase chain 2	N	347	Bos taurus	Mutation(s): 0 EC: 1.6.5.3 Membrane Entity: Yes
UniProt
Find proteins for P03892 (Bos taurus) Explore P03892 Go to UniProtKB: P03892
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UniProt Group	P03892
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Entity ID: 15
Molecule	Chains	Sequence Length	Organism	Details	Image
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial	O	314	Bos taurus	Mutation(s): 0 Membrane Entity: Yes
UniProt
Find proteins for P34942 (Bos taurus) Explore P34942 Go to UniProtKB: P34942
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UniProt Group	P34942
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Reference Sequence

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Entity ID: 16
Molecule	Chains	Sequence Length	Organism	Details	Image
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, NDUFA9	P	283	Bos taurus	Mutation(s): 0
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Entity ID: 17
Molecule	Chains	Sequence Length	Organism	Details	Image
NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, NDUFS4	Q	113	Bos taurus	Mutation(s): 0
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Entity ID: 18
Molecule	Chains	Sequence Length	Organism	Details	Image
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial	R	89	Bos taurus	Mutation(s): 0 Membrane Entity: Yes
UniProt
Find proteins for P23934 (Bos taurus) Explore P23934 Go to UniProtKB: P23934
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UniProt Group	P23934
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Entity ID: 19
Molecule	Chains	Sequence Length	Organism	Details	Image
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2	S	99	Bos taurus	Mutation(s): 0 Membrane Entity: Yes
UniProt
Find proteins for Q02370 (Bos taurus) Explore Q02370 Go to UniProtKB: Q02370
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UniProt Group	Q02370
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Entity ID: 20
Molecule	Chains	Sequence Length	Organism	Details	Image
Acyl carrier protein, mitochondrial	T, U	88	Bos taurus	Mutation(s): 0 Membrane Entity: Yes
UniProt
Find proteins for P52505 (Bos taurus) Explore P52505 Go to UniProtKB: P52505
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UniProt Group	P52505
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Entity ID: 21
Molecule	Chains	Sequence Length	Organism	Details	Image
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	V	115	Bos taurus	Mutation(s): 0 Membrane Entity: Yes
UniProt
Find proteins for P23935 (Bos taurus) Explore P23935 Go to UniProtKB: P23935
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UniProt Group	P23935
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Entity ID: 22
Molecule	Chains	Sequence Length	Organism	Details	Image
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6	W	127	Bos taurus	Mutation(s): 0 Membrane Entity: Yes
UniProt
Find proteins for Q02366 (Bos taurus) Explore Q02366 Go to UniProtKB: Q02366
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UniProt Group	Q02366
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Entity ID: 23
Molecule	Chains	Sequence Length	Organism	Details	Image
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8	X	164	Bos taurus	Mutation(s): 0 Membrane Entity: Yes
UniProt
Find proteins for P42029 (Bos taurus) Explore P42029 Go to UniProtKB: P42029
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UniProt Group	P42029
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Entity ID: 24
Molecule	Chains	Sequence Length	Organism	Details	Image
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11	Y	140	Bos taurus	Mutation(s): 0 Membrane Entity: Yes
UniProt
Find proteins for Q8HXG6 (Bos taurus) Explore Q8HXG6 Go to UniProtKB: Q8HXG6
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UniProt Group	Q8HXG6
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Entity ID: 25
Molecule	Chains	Sequence Length	Organism	Details	Image
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	Z	138	Bos taurus	Mutation(s): 0 Membrane Entity: Yes
UniProt
Find proteins for Q95KV7 (Bos taurus) Explore Q95KV7 Go to UniProtKB: Q95KV7
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UniProt Group	Q95KV7
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Entity ID: 26
Molecule	Chains	Sequence Length	Organism	Details	Image
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	AA [auth a]	70	Bos taurus	Mutation(s): 0 Membrane Entity: Yes
UniProt
Find proteins for Q02377 (Bos taurus) Explore Q02377 Go to UniProtKB: Q02377
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UniProt Group	Q02377
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Entity ID: 27
Molecule	Chains	Sequence Length	Organism	Details	Image
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3	BA [auth b]	80	Bos taurus	Mutation(s): 0 Membrane Entity: Yes
UniProt
Find proteins for Q02371 (Bos taurus) Explore Q02371 Go to UniProtKB: Q02371
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UniProt Group	Q02371
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Entity ID: 28
Molecule	Chains	Sequence Length	Organism	Details	Image
NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial	CA [auth c]	49	Bos taurus	Mutation(s): 0 Membrane Entity: Yes
UniProt
Find proteins for Q02376 (Bos taurus) Explore Q02376 Go to UniProtKB: Q02376
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UniProt Group	Q02376
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Entity ID: 29
Molecule	Chains	Sequence Length	Organism	Details	Image
NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2	DA [auth d]	114	Bos taurus	Mutation(s): 0 Membrane Entity: Yes
UniProt
Find proteins for Q02827 (Bos taurus) Explore Q02827 Go to UniProtKB: Q02827
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UniProt Group	Q02827
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Entity ID: 30
Molecule	Chains	Sequence Length	Organism	Details	Image
NADH dehydrogenase [ubiquinone] iron-sulfur protein 5	EA [auth e]	106	Bos taurus	Mutation(s): 0 Membrane Entity: Yes
UniProt
Find proteins for Q02379 (Bos taurus) Explore Q02379 Go to UniProtKB: Q02379
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UniProt Group	Q02379
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Entity ID: 31
Molecule	Chains	Sequence Length	Organism	Details	Image
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1	FA [auth f]	57	Bos taurus	Mutation(s): 0 Membrane Entity: Yes
UniProt
Find proteins for Q02378 (Bos taurus) Explore Q02378 Go to UniProtKB: Q02378
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UniProt Group	Q02378
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Entity ID: 32
Molecule	Chains	Sequence Length	Organism	Details	Image
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial	GA [auth g]	125	Bos taurus	Mutation(s): 0 Membrane Entity: Yes
UniProt
Find proteins for Q8HXG5 (Bos taurus) Explore Q8HXG5 Go to UniProtKB: Q8HXG5
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UniProt Group	Q8HXG5
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Entity ID: 33
Molecule	Chains	Sequence Length	Organism	Details	Image
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial	HA [auth h]	134	Bos taurus	Mutation(s): 0 Membrane Entity: Yes
UniProt
Find proteins for Q02380 (Bos taurus) Explore Q02380 Go to UniProtKB: Q02380
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UniProt Group	Q02380
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Entity ID: 34
Molecule	Chains	Sequence Length	Organism	Details	Image
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6	IA [auth i]	106	Bos taurus	Mutation(s): 0 Membrane Entity: Yes
UniProt
Find proteins for Q02367 (Bos taurus) Explore Q02367 Go to UniProtKB: Q02367
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UniProt Group	Q02367
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Entity ID: 35
Molecule	Chains	Sequence Length	Organism	Details	Image
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, NDUFB2	JA [auth j]	52	Bos taurus	Mutation(s): 0
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Entity ID: 36
Molecule	Chains	Sequence Length	Organism	Details	Image
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3, NDUFB3	KA [auth k]	74	Bos taurus	Mutation(s): 0
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Entity ID: 37
Molecule	Chains	Sequence Length	Organism	Details	Image
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, NDUFB8	LA [auth l]	118	Bos taurus	Mutation(s): 0
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Entity ID: 38
Molecule	Chains	Sequence Length	Organism	Details	Image
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4	MA [auth m]	118	Bos taurus	Mutation(s): 0 Membrane Entity: Yes
UniProt
Find proteins for P48305 (Bos taurus) Explore P48305 Go to UniProtKB: P48305
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UniProt Group	P48305
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Entity ID: 39
Molecule	Chains	Sequence Length	Organism	Details	Image
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9	NA [auth n]	166	Bos taurus	Mutation(s): 0 Membrane Entity: Yes
UniProt
Find proteins for Q02369 (Bos taurus) Explore Q02369 Go to UniProtKB: Q02369
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UniProt Group	Q02369
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Entity ID: 40
Molecule	Chains	Sequence Length	Organism	Details	Image
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7	OA [auth o]	58	Bos taurus	Mutation(s): 0 Membrane Entity: Yes
UniProt
Find proteins for Q02368 (Bos taurus) Explore Q02368 Go to UniProtKB: Q02368
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UniProt Group	Q02368
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Entity ID: 41
Molecule	Chains	Sequence Length	Organism	Details	Image
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10	PA [auth p]	169	Bos taurus	Mutation(s): 0 Membrane Entity: Yes
UniProt
Find proteins for Q02373 (Bos taurus) Explore Q02373 Go to UniProtKB: Q02373
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UniProt Group	Q02373
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Entity ID: 42
Molecule	Chains	Sequence Length	Organism	Details	Image
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12	QA [auth q]	138	Bos taurus	Mutation(s): 0 Membrane Entity: Yes
UniProt
Find proteins for O97725 (Bos taurus) Explore O97725 Go to UniProtKB: O97725
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UniProt Group	O97725
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Entity ID: 43
Molecule	Chains	Sequence Length	Organism	Details	Image
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7, NDUFA7	RA [auth r]	87	Bos taurus	Mutation(s): 0
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Entity ID: 44
Molecule	Chains	Sequence Length	Organism	Details	Image
NADH dehydrogenase [ubiquinone] flavoprotein 3, NDUFV3	SA [auth s]	35	Bos taurus	Mutation(s): 0
Sequence Annotations Expand
Reference Sequence

Small Molecules

Ligands 5 Unique
ID	Chains	Name / Formula / InChI Key	2D Diagram	3D Interactions
NAP Query on NAP Download Ideal Coordinates CCD File SDF format, chain CB [auth P] MOL2 format, chain CB [auth P]	CB [auth P]	NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE C₂₁ H₂₈ N₇ O₁₇ P₃ XJLXINKUBYWONI-NNYOXOHSSA-N		Interactions Focus chain CB [auth P] Interactions & Density Focus chain CB [auth P]
FMN Query on FMN Download Ideal Coordinates CCD File SDF format, chain VA [auth F] MOL2 format, chain VA [auth F]	VA [auth F]	FLAVIN MONONUCLEOTIDE C₁₇ H₂₁ N₄ O₉ P FVTCRASFADXXNN-SCRDCRAPSA-N		Interactions Focus chain VA [auth F] Interactions & Density Focus chain VA [auth F]
SF4 Query on SF4 Download Ideal Coordinates CCD File SDF format, chain AB [auth I] SDF format, chain BB [auth I] SDF format, chain TA [auth B] SDF format, chain WA [auth F] SDF format, chain XA [auth G] SDF format, chain YA [auth G] MOL2 format, chain AB [auth I] MOL2 format, chain BB [auth I] MOL2 format, chain TA [auth B] MOL2 format, chain WA [auth F] MOL2 format, chain XA [auth G] MOL2 format, chain YA [auth G]	AB [auth I] BB [auth I] TA [auth B] WA [auth F] XA [auth G] AB [auth I], BB [auth I], TA [auth B], WA [auth F], XA [auth G], YA [auth G]	IRON/SULFUR CLUSTER Fe₄ S₄ LJBDFODJNLIPKO-UHFFFAOYSA-N		Interactions Focus chain AB [auth I] Focus chain BB [auth I] Focus chain TA [auth B] Focus chain WA [auth F] Focus chain XA [auth G] Focus chain YA [auth G] Interactions & Density Focus chain AB [auth I] Focus chain BB [auth I] Focus chain TA [auth B] Focus chain WA [auth F] Focus chain XA [auth G] Focus chain YA [auth G]
FES Query on FES Download Ideal Coordinates CCD File SDF format, chain UA [auth E] SDF format, chain ZA [auth G] MOL2 format, chain UA [auth E] MOL2 format, chain ZA [auth G]	UA [auth E], ZA [auth G]	FE2/S2 (INORGANIC) CLUSTER Fe₂ S₂ NIXDOXVAJZFRNF-UHFFFAOYSA-N		Interactions Focus chain UA [auth E] Focus chain ZA [auth G] Interactions & Density Focus chain UA [auth E] Focus chain ZA [auth G]
ZN Query on ZN Download Ideal Coordinates CCD File SDF format, chain DB [auth R] MOL2 format, chain DB [auth R]	DB [auth R]	ZINC ION Zn PTFCDOFLOPIGGS-UHFFFAOYSA-N		Interactions Focus chain DB [auth R] Interactions & Density Focus chain DB [auth R]