Download MendeleyStructure of Mcl-1 complexed with Mule at 2.05 Angstroms resolution
Song, T., Wang, Z., Ji, F., Chai, G., Liu, Y., Li, X., Li, Z., Fan, Y., Zhang, Z.To be published.
5C6H
Mcl-1 complexed with Mule
- PDB DOI: https://doi.org/10.2210/pdb5C6H/pdb
- Classification: APOPTOSIS/APOPTOSIS REGULATOR
- Organism(s): Homo sapiens
- Expression System: Escherichia coli
- Mutation(s): No
- Deposited: 2015-06-23 Released: 2016-08-03
- Funding Organization(s): National Natural Science Foundation of China
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 2.05 Å
- R-Value Free: 0.346
- R-Value Work: 0.295
- R-Value Observed: 0.297
wwPDB Validation 3D Report Full Report
This is version 1.2 of the entry. See complete history.
Literature
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Induced myeloid leukemia cell differentiation protein Mcl-1 | 157 | Homo sapiens | Mutation(s): 0 Gene Names: MCL1, BCL2L3 |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for Q07820 (Homo sapiens) Explore Q07820 Go to UniProtKB: Q07820 | |||||
PHAROS: Q07820 GTEx: ENSG00000143384 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | Q07820 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 2 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Mule BH3 peptide from E3 ubiquitin-protein ligase HUWE1 | 26 | Homo sapiens | Mutation(s): 0 |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for Q7Z6Z7 (Homo sapiens) Explore Q7Z6Z7 Go to UniProtKB: Q7Z6Z7 | |||||
PHAROS: Q7Z6Z7 GTEx: ENSG00000086758 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | Q7Z6Z7 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 2.05 Å
- R-Value Free: 0.346
- R-Value Work: 0.295
- R-Value Observed: 0.297
- Space Group: P 1
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 31.79 | α = 90.12 |
| b = 114.24 | β = 92.32 |
| c = 135.98 | γ = 90.01 |
| Software Name | Purpose |
|---|---|
| PHENIX | refinement |
| HKL-2000 | data collection |
| PHENIX | model building |
| Coot | data processing |
| XDS | data reduction |
| Coot | phasing |
| HKL-2000 | data extraction |
Entry History & Funding Information
Deposition Data
- Released Date: 2016-08-03 Deposition Author(s): Song, T., Wang, Z., Ji, F., Chai, G., Liu, Y., Li, X., Li, Z., Fan, Y., Zhang, Z.
| Funding Organization | Location | Grant Number |
|---|---|---|
| National Natural Science Foundation of China | China | 21402022 |
| National Natural Science Foundation of China | China | 21372036 |
Revision History (Full details and data files)
- Version 1.0: 2016-08-03
Type: Initial release - Version 1.1: 2017-10-18
Changes: Author supporting evidence, Derived calculations - Version 1.2: 2024-03-20
Changes: Data collection, Database references
