Download MendeleyCapturing HCV immune escape by targeting structural based mechanism
Hui, F.To be published.
5YXN
A T cell receptor in complex with HLA-A0201 restricted Hepatitis C virus NS3 peptide (KLVALGINAV)
- PDB DOI: https://doi.org/10.2210/pdb5YXN/pdb
- Classification: IMMUNE SYSTEM
- Organism(s): Homo sapiens, Hepacivirus hominis
- Expression System: Escherichia coli
- Mutation(s): No
- Deposited: 2017-12-06 Released: 2018-12-12
- Funding Organization(s): Science and Technology Program of Guangzhou, National Key R&D program
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 2.03 Å
- R-Value Free: 0.223
- R-Value Work: 0.193
- R-Value Observed: 0.194
wwPDB Validation 3D Report Full Report
This is version 1.0 of the entry. See complete history.
Literature
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| T cell receptor alpha chain | 192 | Homo sapiens | Mutation(s): 0 |  | |
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
Sequence AnnotationsExpand | |||||
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Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 2 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| T cell receptor beta chain | 241 | Homo sapiens | Mutation(s): 0 |  | |
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
Sequence AnnotationsExpand | |||||
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Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 3 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| HLA class I histocompatibility antigen, A-2 alpha chain | 275 | Homo sapiens | Mutation(s): 0 Gene Names: HLA-A, HLAA |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P04439 (Homo sapiens) Explore P04439 Go to UniProtKB: P04439 | |||||
PHAROS: P04439 GTEx: ENSG00000206503 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P04439 | ||||
Sequence AnnotationsExpand | |||||
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Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 4 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Beta-2-microglobulin | 100 | Homo sapiens | Mutation(s): 0 |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P61769 (Homo sapiens) Explore P61769 Go to UniProtKB: P61769 | |||||
PHAROS: P61769 GTEx: ENSG00000166710 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P61769 | ||||
Sequence AnnotationsExpand | |||||
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Find similar proteins by: Sequence | 3D Structure
Entity ID: 5 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| NS3 peptide | E [auth I] | 10 | Hepacivirus hominis | Mutation(s): 0 |  |
UniProt | |||||
Find proteins for P27958 (Hepatitis C virus genotype 1a (isolate H77)) Explore P27958 Go to UniProtKB: P27958 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P27958 | ||||
Sequence AnnotationsExpand | |||||
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Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 2.03 Å
- R-Value Free: 0.223
- R-Value Work: 0.193
- R-Value Observed: 0.194
- Space Group: I 1 2 1
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 79.99 | α = 90 |
| b = 53.65 | β = 95.27 |
| c = 224.981 | γ = 90 |
| Software Name | Purpose |
|---|---|
| SCALA | data scaling |
| REFMAC | refinement |
| PDB_EXTRACT | data extraction |
| MOSFLM | data reduction |
| PHASER | phasing |
Entry History & Funding Information
Deposition Data
- Released Date: 2018-12-12 Deposition Author(s): Hui, F.
| Funding Organization | Location | Grant Number |
|---|---|---|
| Science and Technology Program of Guangzhou | China | 201504010016 |
| National Key R&D program | China | 2016YFC1303404 |
| Science and Technology Program of Guangzhou | China | 201704020220 |
Revision History (Full details and data files)
- Version 1.0: 2018-12-12
Type: Initial release
