Download MendeleySingle mutation, L63P, capable of shutting down the flaps of HIV-1 protease
Liu, Z., Norell, J., Mahon, B., Poole, K., McKenna, R., Fanucci, G.To be published.
5T84
HIV-1 protease, unbound subtype B L63P construct
- PDB DOI: https://doi.org/10.2210/pdb5T84/pdb
- Classification: HYDROLASE
- Organism(s): Human immunodeficiency virus 1
- Expression System: Escherichia coli K-12
- Mutation(s): No
- Deposited: 2016-09-06 Released: 2017-09-20
- Funding Organization(s): National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS), National Institutes of Health/National Center for Research Resources (NIH/NCRR), National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 1.65 Å
- R-Value Free: 0.202
- R-Value Work: 0.177
- R-Value Observed: 0.179
wwPDB Validation 3D Report Full Report
This is version 1.2 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Protease | 99 | Human immunodeficiency virus 1 | Mutation(s): 0 Gene Names: pol |  | |
UniProt | |||||
Find proteins for Q6QK01 (Human immunodeficiency virus 1) Explore Q6QK01 Go to UniProtKB: Q6QK01 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | Q6QK01 | ||||
Sequence AnnotationsExpand | |||||
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Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 1.65 Å
- R-Value Free: 0.202
- R-Value Work: 0.177
- R-Value Observed: 0.179
- Space Group: P 2 21 21
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 46.29 | α = 90 |
| b = 58.01 | β = 90 |
| c = 85.86 | γ = 90 |
| Software Name | Purpose |
|---|---|
| PHENIX | refinement |
| iMOSFLM | data reduction |
| Aimless | data scaling |
| PHASER | phasing |
Entry History & Funding Information
Deposition Data
- Released Date: 2017-09-20 Deposition Author(s): Liu, Z., Norell, J., Mahon, B., Poole, K., McKenna, R., Fanucci, G.
| Funding Organization | Location | Grant Number |
|---|---|---|
| National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | United States | GM105409 |
| National Institutes of Health/National Center for Research Resources (NIH/NCRR) | United States | S10RR031603 |
| National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) | United States | R37 A128571 |
Revision History (Full details and data files)
- Version 1.0: 2017-09-20
Type: Initial release - Version 1.1: 2019-12-04
Changes: Author supporting evidence - Version 1.2: 2022-03-23
Changes: Author supporting evidence, Database references
