5KAN
Crystal structure of multidonor HV1-18-class broadly neutralizing Influenza A antibody 16.g.07 in complex with A/Hong Kong/1-4-MA21-1/1968 (H3N2) Hemagglutinin
- PDB DOI: https://doi.org/10.2210/pdb5KAN/pdb
- Classification: IMMUNE SYSTEM
- Organism(s): Influenza A virus (A/Hong Kong/1/1968(H3N2)), Homo sapiens
- Expression System: Homo sapiens
- Mutation(s): No
- Deposited: 2016-06-01 Released: 2016-11-30
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 2.79 Å
- R-Value Free: 0.243
- R-Value Work: 0.218
- R-Value Observed: 0.219
This is version 1.2 of the entry. See complete history.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Hemagglutinin HA1 | 319 | Influenza A virus (A/Hong Kong/1/1968(H3N2)) | Mutation(s): 0 Gene Names: HA |  | |
UniProt | |||||
Find proteins for Q91MA7 (Influenza A virus (strain A/Hong Kong/1/1968 H3N2)) Explore Q91MA7 Go to UniProtKB: Q91MA7 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | Q91MA7 | ||||
Sequence AnnotationsExpand | |||||
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(by identity cutoff) | 3D Structure
Entity ID: 2 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Hemagglutinin HA2 | 173 | Influenza A virus (A/Hong Kong/1/1968(H3N2)) | Mutation(s): 0 Gene Names: HA |  | |
UniProt | |||||
Find proteins for Q91MA7 (Influenza A virus (strain A/Hong Kong/1/1968 H3N2)) Explore Q91MA7 Go to UniProtKB: Q91MA7 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | Q91MA7 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 3 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| 16.g.07 Heavy chain | 231 | Homo sapiens | Mutation(s): 0 |  | |
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
Sequence AnnotationsExpand | |||||
| |||||
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 4 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| 16.g.07 Light chain | 214 | Homo sapiens | Mutation(s): 0 |  | |
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
Sequence AnnotationsExpand | |||||
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Small Molecules
| Ligands 1 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| NAG Query on NAG | AA [auth E] BA [auth E] CA [auth F] M [auth A] N [auth A] | 2-acetamido-2-deoxy-beta-D-glucopyranose C8 H15 N O6 OVRNDRQMDRJTHS-FMDGEEDCSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 2.79 Å
- R-Value Free: 0.243
- R-Value Work: 0.218
- R-Value Observed: 0.219
- Space Group: P 21 21 21
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 128.847 | α = 90 |
| b = 147.562 | β = 90 |
| c = 209.786 | γ = 90 |
| Software Name | Purpose |
|---|---|
| PHENIX | refinement |
| PDB_EXTRACT | data extraction |
| HKL-2000 | data reduction |
| HKL-2000 | data scaling |
| PHASER | phasing |
Entry History
Deposition Data
- Released Date: 2016-11-30 Deposition Author(s): Joyce, M.G., Thomas, P.V., Wheatley, A.K., McDermott, A.B., Mascola, J.R., Kwong, P.D.
Revision History (Full details and data files)
- Version 1.0: 2016-11-30
Type: Initial release - Version 1.1: 2020-07-29
Type: Remediation
Reason: Carbohydrate remediation
Changes: Advisory, Data collection, Database references, Derived calculations, Structure summary - Version 1.2: 2023-09-27
Changes: Advisory, Data collection, Database references, Refinement description, Structure summary
