5ID1
Cetuximab Fab in complex with MPT-Cys meditope
- PDB DOI: https://doi.org/10.2210/pdb5ID1/pdb
- Classification: IMMUNE SYSTEM
- Organism(s): Mus musculus, Homo sapiens, synthetic construct
- Expression System: unidentified
- Mutation(s): No
- Deposited: 2016-02-23 Released: 2016-06-15
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 2.49 Å
- R-Value Free: 0.221
- R-Value Work: 0.173
- R-Value Observed: 0.175
This is version 1.3 of the entry. See complete history.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Cetuximab Fab light chain | 213 | Mus musculus, Homo sapiens This entity is chimeric | Mutation(s): 0 |  | |
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
Sequence AnnotationsExpand | |||||
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Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 2 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Cetuximab Fab heavy chain | 221 | Mus musculus, Homo sapiens This entity is chimeric | Mutation(s): 0 |  | |
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
Sequence AnnotationsExpand | |||||
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Find similar proteins by: Sequence | 3D Structure
Entity ID: 3 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Meditope | 12 | synthetic construct | Mutation(s): 0 |  | |
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
Sequence AnnotationsExpand | |||||
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Small Molecules
| Ligands 2 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| NAG Query on NAG | G [auth B] | 2-acetamido-2-deoxy-beta-D-glucopyranose C8 H15 N O6 OVRNDRQMDRJTHS-FMDGEEDCSA-N |  | ||
| PO4 Query on PO4 | H [auth B], I [auth B], J [auth C], K [auth D] | PHOSPHATE ION O4 P NBIIXXVUZAFLBC-UHFFFAOYSA-K |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 2.49 Å
- R-Value Free: 0.221
- R-Value Work: 0.173
- R-Value Observed: 0.175
- Space Group: P 21 21 21
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 64.16 | α = 90 |
| b = 83.16 | β = 90 |
| c = 212.58 | γ = 90 |
| Software Name | Purpose |
|---|---|
| XDS | data reduction |
| XSCALE | data scaling |
| MOLREP | phasing |
| PHENIX | refinement |
Entry History
Deposition Data
- Released Date: 2016-06-15 Deposition Author(s): Bzymek, K.P., Williams, J.C.
Revision History (Full details and data files)
- Version 1.0: 2016-06-15
Type: Initial release - Version 1.1: 2017-12-13
Changes: Database references, Derived calculations - Version 1.2: 2020-07-29
Type: Remediation
Reason: Carbohydrate remediation
Changes: Data collection, Derived calculations, Structure summary - Version 1.3: 2023-09-27
Changes: Data collection, Database references, Refinement description, Structure summary
