5E6T

Structural analysis of bovine norovirus protruding domain.

(2015) Virology 487: 296-301

• PubMed: 26599362 Search on PubMed
• DOI: https://doi.org/10.1016/j.virol.2015.10.022
• Primary Citation of Related Structures:  
  5E6T


• PubMed Abstract: 
  

  We determined a structure of a bovine (genogroup III, GIII) norovirus capsid protruding (P) domain using X-ray crystallography. The bovine P domain was reminiscent of other norovirus genogroups (GI, GII, GIV, and GV), but closely matched the human GI P domain. We also identified a monoclonal antibody that was capable of binding the five different (GI-GV) P domains. Our data suggests that genetically diverse noroviruses still contain common epitopes.

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Organizational Affiliation: 

Schaller Research Group at the University of Heidelberg and the DKFZ, Heidelberg 69120, Germany; Department of Infectious Diseases, Virology, University of Heidelberg, Heidelberg 69120, Germany.