Download MendeleyCrystal Structure of O-Acetylserine Sulfhydrylase from Haemophilus inuen-zae in complex with pre-reactive o-acetyl serine and peptide inhibitor
Ekka, M.K., Singh, A.K., Kaushik, A., Kumaran, S.To be published.
4ZU6
Crystal Structure of O-Acetylserine Sulfhydrylase from Haemophilus influenzae in complex with pre-reactive o-acetyl serine, alpha-aminoacrylate reaction intermediate and Peptide inhibitor at the resolution of 2.25A
- PDB DOI: https://doi.org/10.2210/pdb4ZU6/pdb
- Entry: 4ZU6 supersedes: 4MH9
- Classification: Transferase/Transferase Inhibitor
- Organism(s): Haemophilus influenzae Rd KW20, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
- Expression System: Escherichia coli BL21(DE3)
- Mutation(s): No
- Deposited: 2015-05-15 Released: 2015-06-10
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 2.03 Å
- R-Value Free: 0.230
- R-Value Work: 0.189
- R-Value Observed: 0.191
This is version 1.1 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Cysteine synthase | A [auth X] | 332 | Haemophilus influenzae Rd KW20 | Mutation(s): 0 Gene Names: cysK, HI_1103 EC: 2.5.1.47 |  |
UniProt | |||||
Find proteins for P45040 (Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)) Explore P45040 Go to UniProtKB: P45040 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P45040 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Find similar proteins by: Sequence | 3D Structure
Entity ID: 2 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| C-terminal peptide from Serine acetyltransferase | 10 | Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 | Mutation(s): 0 |  | |
UniProt | |||||
Find proteins for P29847 (Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)) Explore P29847 Go to UniProtKB: P29847 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P29847 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 2 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| PLP Query on PLP | D [auth X] | PYRIDOXAL-5'-PHOSPHATE C8 H10 N O6 P NGVDGCNFYWLIFO-UHFFFAOYSA-N |  | ||
| OAS Query on OAS | C [auth X] | O-ACETYLSERINE C5 H9 N O4 VZXPDPZARILFQX-BYPYZUCNSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 2.03 Å
- R-Value Free: 0.230
- R-Value Work: 0.189
- R-Value Observed: 0.191
- Space Group: I 41
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 112.634 | α = 90 |
| b = 112.634 | β = 90 |
| c = 43.49 | γ = 90 |
| Software Name | Purpose |
|---|---|
| PHENIX | refinement |
| HKL-2000 | data reduction |
| HKL-2000 | data scaling |
| PHASER | phasing |
Entry History
Deposition Data
- Released Date: 2015-06-10 Deposition Author(s): Ekka, M.K., Singh, A.K., Kaushik, A., Kumaran, S.
- This entry supersedes: 4MH9
Revision History (Full details and data files)
- Version 1.0: 2015-06-10
Type: Initial release - Version 1.1: 2023-11-08
Changes: Data collection, Database references, Derived calculations, Refinement description, Source and taxonomy
