Download MendeleyThe crystal structure of mupain-1-IG in complex with murinised human uPA at pH7.4
Jiang, L., Andreasen, P.A., Huang, M.To be published.
4ZKN
The crystal structure of upain-1-W3A in complex with uPA at pH5.5
- PDB DOI: https://doi.org/10.2210/pdb4ZKN/pdb
- Classification: HYDROLASE/HYDROLASE INHIBITOR
- Organism(s): Homo sapiens, synthetic construct
- Expression System: Komagataella pastoris
- Mutation(s): Yes
- Deposited: 2015-04-30 Released: 2016-05-18
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 1.36 Å
- R-Value Free: 0.265
- R-Value Work: 0.228
- R-Value Observed: 0.229
wwPDB Validation 3D Report Full Report
This is version 1.1 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Urokinase-type plasminogen activator | A [auth U] | 247 | Homo sapiens | Mutation(s): 2 Gene Names: PLAU EC: 3.4.21.73 |  |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P00749 (Homo sapiens) Explore P00749 Go to UniProtKB: P00749 | |||||
PHAROS: P00749 GTEx: ENSG00000122861 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P00749 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Find similar proteins by: Sequence | 3D Structure
Entity ID: 2 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| upain-1-W3A | B [auth P] | 12 | synthetic construct | Mutation(s): 0 |  |
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 2 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| PG4 Query on PG4 | D [auth U], E [auth U] | TETRAETHYLENE GLYCOL C8 H18 O5 UWHCKJMYHZGTIT-UHFFFAOYSA-N |  | ||
| SO4 Query on SO4 | C [auth U] | SULFATE ION O4 S QAOWNCQODCNURD-UHFFFAOYSA-L |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 1.36 Å
- R-Value Free: 0.265
- R-Value Work: 0.228
- R-Value Observed: 0.229
- Space Group: H 3
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 121.049 | α = 90 |
| b = 121.049 | β = 90 |
| c = 42.979 | γ = 120 |
| Software Name | Purpose |
|---|---|
| REFMAC | refinement |
| HKL-2000 | data scaling |
| Coot | model building |
Entry History
Deposition Data
- Released Date: 2016-05-18 Deposition Author(s): Jiang, L., Andreasen, P.A., Huang, M.
Revision History (Full details and data files)
- Version 1.0: 2016-05-18
Type: Initial release - Version 1.1: 2023-11-08
Changes: Data collection, Database references, Derived calculations, Refinement description
