Structural insights into the loss of penicillinase and the gain of ceftazidimase activities by OXA-145 beta-lactamase in Pseudomonas aeruginosa.
Meziane-Cherif, D., Bonnet, R., Haouz, A., Courvalin, P.(2016) J Antimicrob Chemother 71: 395-402
- PubMed: 26568564 
- DOI: https://doi.org/10.1093/jac/dkv375
- Primary Citation of Related Structures:  
4YIN - PubMed Abstract: 
We previously described extended-spectrum oxacillinase OXA-145 from Pseudomonas aeruginosa, which differs from narrow-spectrum OXA-35 by loss of Leu-155. The deletion results in loss of benzylpenicillin hydrolysis and acquisition of activity against ceftazidime. We report the crystal structure of OXA-145 and provide the basis of its switch in substrate specificity.
Organizational Affiliation: 
Institut Pasteur, Unité des Agents Antibactériens, 25 rue du Docteur Roux, 75724 Paris cedex 15, France.