Download MendeleyCRYSTAL STRUCTURE OF CANDIDA ALBICANS PROTEIN FARNESYLTRANSFERASE BINARY COMPLEX WITH THE ISOPRENOID FARNESYLDIPHOSPHATE
Kumar, S., Mabanglo, M.F., Hast, M.A., Shi, Y., Beese, L.S.To be published.
4YDE
CRYSTAL STRUCTURE OF CANDIDA ALBICANS PROTEIN FARNESYLTRANSFERASE BINARY COMPLEX WITH THE ISOPRENOID FARNESYLDIPHOSPHATE
- PDB DOI: https://doi.org/10.2210/pdb4YDE/pdb
- Classification: TRANSFERASE
- Organism(s): Candida albicans SC5314
- Expression System: Escherichia coli
- Mutation(s): No
- Deposited: 2015-02-22 Released: 2016-07-06
- Funding Organization(s): National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 2.70 Å
- R-Value Free: 0.228
- R-Value Work: 0.195
- R-Value Observed: 0.197
This is version 1.3 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | 329 | Candida albicans SC5314 | Mutation(s): 0 Gene Names: RAM2, CaO19.12280, CaO19.4817 |  | |
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
Sequence AnnotationsExpand | |||||
| |||||
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 2 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Protein farnesyltransferase/geranylgeranyltransferase type-1 Subunit beta | 587 | Candida albicans SC5314 | Mutation(s): 0 Gene Names: RAM1, CaO19.12513 |  | |
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 3 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| 4C7 Query on 4C7 | E [auth B] | (3R,7S)-3,7,11-trimethyldodecyl trihydrogen diphosphate C15 H34 O7 P2 QLJFEPYMTKDKMH-LSDHHAIUSA-N |  | ||
| ZN Query on ZN | D [auth B] | ZINC ION Zn PTFCDOFLOPIGGS-UHFFFAOYSA-N |  | ||
| EDO Query on EDO | C [auth A], F [auth B] | 1,2-ETHANEDIOL C2 H6 O2 LYCAIKOWRPUZTN-UHFFFAOYSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 2.70 Å
- R-Value Free: 0.228
- R-Value Work: 0.195
- R-Value Observed: 0.197
- Space Group: P 43 2 2
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 98.874 | α = 90 |
| b = 98.874 | β = 90 |
| c = 188.616 | γ = 90 |
| Software Name | Purpose |
|---|---|
| PHENIX | refinement |
| HKL-2000 | data reduction |
| SCALEPACK | data scaling |
| PHASER | phasing |
Entry History & Funding Information
Deposition Data
- Released Date: 2016-07-06 Deposition Author(s): Kumar, S., Mabanglo, M.F., Hast, M.A., Shi, Y., Beese, L.S.
| Funding Organization | Location | Grant Number |
|---|---|---|
| National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | United States | -- |
Revision History (Full details and data files)
- Version 1.0: 2016-07-06
Type: Initial release - Version 1.1: 2017-09-13
Changes: Author supporting evidence, Derived calculations - Version 1.2: 2022-03-30
Changes: Author supporting evidence, Database references - Version 1.3: 2023-09-27
Changes: Data collection, Refinement description
