Download MendeleyCrystal Structure of Mutant R89Q of human Adenine phosphoribosyltransferase
Pimenta, A., Pereira, H.M., Mercaldi, G., Thiemann, O.H.To be published.
4X44
Crystal Structure of Mutant R89Q of human Adenine phosphoribosyltransferase
- PDB DOI: https://doi.org/10.2210/pdb4X44/pdb
- Classification: TRANSFERASE
- Organism(s): Homo sapiens
- Expression System: Escherichia coli BL21(DE3)
- Mutation(s): Yes
- Deposited: 2014-12-02 Released: 2015-12-02
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 2.05 Å
- R-Value Free: 0.203
- R-Value Work: 0.170
- R-Value Observed: 0.172
This is version 1.1 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Adenine phosphoribosyltransferase | 180 | Homo sapiens | Mutation(s): 1 Gene Names: APRT EC: 2.4.2.7 |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P07741 (Homo sapiens) Explore P07741 Go to UniProtKB: P07741 | |||||
PHAROS: P07741 GTEx: ENSG00000198931 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P07741 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 3 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| AMP Query on AMP | B [auth A] | ADENOSINE MONOPHOSPHATE C10 H14 N5 O7 P UDMBCSSLTHHNCD-KQYNXXCUSA-N |  | ||
| SO4 Query on SO4 | C [auth A] | SULFATE ION O4 S QAOWNCQODCNURD-UHFFFAOYSA-L |  | ||
| GOL Query on GOL | D [auth A] | GLYCEROL C3 H8 O3 PEDCQBHIVMGVHV-UHFFFAOYSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 2.05 Å
- R-Value Free: 0.203
- R-Value Work: 0.170
- R-Value Observed: 0.172
- Space Group: P 43 21 2
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 59.493 | α = 90 |
| b = 59.493 | β = 90 |
| c = 109.772 | γ = 90 |
| Software Name | Purpose |
|---|---|
| MOSFLM | data reduction |
| SCALA | data scaling |
| PHENIX | refinement |
| PDB_EXTRACT | data extraction |
| MOLREP | phasing |
Entry History
Deposition Data
- Released Date: 2015-12-02 Deposition Author(s): Pimenta, A., Pereira, H.M., Mercaldi, G., Thiemann, O.H.
Revision History (Full details and data files)
- Version 1.0: 2015-12-02
Type: Initial release - Version 1.1: 2024-02-28
Changes: Data collection, Database references, Derived calculations
