4U3Y

Apo Mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4)

PDB DOI: https://doi.org/10.2210/pdb4U3Y/pdb

Classification: TRANSFERASE
Organism(s): Homo sapiens
Expression System: Spodoptera frugiperda
Mutation(s): No

Deposited: 2014-07-23 Released: 2016-01-06
Deposition Author(s): Harris, S.F., Wu, P., Coons, M.

Experimental Data Snapshot

Method: X-RAY DIFFRACTION
Resolution: 1.45 Å
R-Value Free: 0.207
R-Value Work: 0.183
R-Value Observed: 0.184

wwPDB Validation 3D Report Full Report

This is version 1.1 of the entry. See complete history.

Literature

Structural Plasticity and Kinase Activation in a Cohort of MAP4K4 Structures

Wu, P., Chen, H., Coons, M., Crawford, T.D., Kirkpatrick, D.S., Murray, L., Ndubaku, C.O., Nonomiya, J., Pham, V., Schmidt, S., Smysczek, T., Vitorino, P., Ye, W., Harris, S.F.

To be published.

Macromolecule Content

Total Structure Weight: 75.82 kDa
Atom Count: 5,581
Modelled Residue Count: 595
Deposited Residue Count: 664
Unique protein chains: 1

Macromolecules

Find similar proteins by:

(by identity cutoff) | 3D Structure

Entity ID: 1
Molecule	Chains	Sequence Length	Organism	Details	Image
Mitogen-activated protein kinase kinase kinase kinase 4	A, B	332	Homo sapiens	Mutation(s): 0 Gene Names: MAP4K4, HGK, KIAA0687, NIK EC: 2.7.11.1
UniProt & NIH Common Fund Data Resources
Find proteins for O95819 (Homo sapiens) Explore O95819 Go to UniProtKB: O95819
PHAROS: O95819 GTEx: ENSG00000071054
Entity Groups
Sequence Clusters	30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity
UniProt Group	O95819
Sequence Annotations Expand
Reference Sequence

Small Molecules

Ligands 1 Unique
ID	Chains	Name / Formula / InChI Key	2D Diagram	3D Interactions
DMS Query on DMS Download Ideal Coordinates CCD File SDF format, chain C [auth B] MOL2 format, chain C [auth B]	C [auth B]	DIMETHYL SULFOXIDE C₂ H₆ O S IAZDPXIOMUYVGZ-UHFFFAOYSA-N		Interactions Focus chain C [auth B] Interactions & Density Focus chain C [auth B]

Experimental Data & Validation

Experimental Data

Method: X-RAY DIFFRACTION
Resolution: 1.45 Å
R-Value Free: 0.207
R-Value Work: 0.183
R-Value Observed: 0.184
Space Group: P 2₁ 2₁ 2₁

Unit Cell:

Length ( Å )	Angle ( ˚ )
a = 80.407	α = 90
b = 80.839	β = 90
c = 92.953	γ = 90

Software Package:

Software Name	Purpose
SCALEPACK	data scaling
PDB_EXTRACT	data extraction
BUSTER	refinement

Structure Validation

View Full Validation Report

Entry History

Deposition Data

Released Date: 2016-01-06

Deposition Author(s):

Revision History (Full details and data files)

Version 1.0: 2016-01-06
Type: Initial release
Version 1.1: 2023-12-27
Changes: Data collection, Database references, Derived calculations

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.