Download Mendeleystucuture of metallo-beta-lactamase
Ferguson, J.A., Makena, A., Brem, J., McDonough, M.A., Schofield, C.J.To be published.
4TZE
Structure of metallo-beta-lactamase
- PDB DOI: https://doi.org/10.2210/pdb4TZE/pdb
- Classification: HYDROLASE
- Organism(s): Escherichia coli
- Expression System: Escherichia coli BL21(DE3)
- Mutation(s): No
- Deposited: 2014-07-10 Released: 2015-07-29
- Funding Organization(s): Medical Research Council (United Kingdom)
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 1.57 Å
- R-Value Free: 0.234
- R-Value Work: 0.195
- R-Value Observed: 0.196
wwPDB Validation 3D Report Full Report
This is version 2.1 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Class B carbapenemase NDM-5 | 231 | Escherichia coli | Mutation(s): 0 Gene Names: blaNDM-5 |  | |
UniProt | |||||
Find proteins for G3K399 (Escherichia coli) Explore G3K399 Go to UniProtKB: G3K399 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | G3K399 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 1 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| ZN Query on ZN | C [auth A], D [auth A], E [auth B], F [auth B] | ZINC ION Zn PTFCDOFLOPIGGS-UHFFFAOYSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 1.57 Å
- R-Value Free: 0.234
- R-Value Work: 0.195
- R-Value Observed: 0.196
- Space Group: P 1 21 1
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 53.773 | α = 90 |
| b = 59.216 | β = 92.19 |
| c = 62.968 | γ = 90 |
| Software Name | Purpose |
|---|---|
| PHENIX | refinement |
| HKL-2000 | data reduction |
| HKL-2000 | data scaling |
| Coot | model building |
| PHASER | phasing |
Entry History & Funding Information
Deposition Data
- Released Date: 2015-07-29 Deposition Author(s): Ferguson, J.A., Makena, A., Brem, J., McDonough, M.A., Schofield, C.J.
| Funding Organization | Location | Grant Number |
|---|---|---|
| Medical Research Council (United Kingdom) | United Kingdom | G1100135 |
Revision History (Full details and data files)
- Version 1.0: 2015-07-29
Type: Initial release - Version 2.0: 2017-09-13
Changes: Advisory, Atomic model, Author supporting evidence, Derived calculations - Version 2.1: 2023-12-20
Changes: Data collection, Database references, Derived calculations, Refinement description
