Crystal structure of a topoisomerase ATP inhibitor
4LP0
Primary Citation
 
 
  •   Molecular Description Hide
    Classification: Isomerase/isomerase Inhibitor
    Structure Weight: 25038.30
    Molecule: Topoisomerase IV subunit B
    Polymer: 1 Type: protein Length: 226
    Chains: A
    EC#: 5.99.1.3   
    Fragment: ATPase domain, UNP residues 1-226
    Organism: Streptococcus pneumoniae R6
    Gene Names: parE spr0756
    UniProtKB: Protein Feature View | Search PDB | Q8DQB5  
     
  •   Structure Validation Hide

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  • MolProbity Ramachandran Plot
     

  •   Related Citations in PDB Entry (REMARK 1) Hide
     
  •   Source Hide
    Polymer: 1
    Scientific Name: Streptococcus pneumoniae   Taxonomy   Expression System: Escherichia coli  
     
  •   Related PDB Entries Hide
    Identifier Details
    4LPB    
     
  •   Ligand Chemical Component Hide
    Identifier Formula Name View Interactions
    1YM
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    1YM C18 H14 F3 N5 O3 S
    6'-[(ethylcarbamoyl)amino]-4'-[4-(trifluoromethyl)- 1,3-thiazol-2-yl]-3,3'-bipyridine-5-carboxylic acid
    1YM:4LP0
     
  •   External Ligand Annotations Hide
    Identifier   Binding Affinity (Sequence Identity %)
    1YM
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    1YM
    N/Ain BindingDB
    IC50: 10 nM - data from BindingMOAD  
    N/Ain PDBbind
     
  •   External Domain Annotations Hide
     
  •   Structural Biology Knowledgebase Data Hide
     
 
Data in orange boxes are gathered from external resources (when available).
  Biological Assembly       
Biological assembly 1 assigned by authors and generated by PISA (software)
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