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Human dCK C4S-S74E mutant in complex with UDP and the DI-43 inhibitor
4L5B
Primary Citation
 
 
  •   Molecular Description Hide
    Classification: Transferase/transferase Inhibitor
    Structure Weight: 67163.37
    Molecule: Deoxycytidine kinase
    Polymer: 1 Type: protein Length: 280
    Chains: A, B
    EC#: 2.7.1.74   
    Fragment: Human deoxycytidine kinase
    Mutation: C9S, C45S, C59S, S74E, C146S
    Organism: Homo sapiens
    Gene Name: Gene View for DCK
    UniProtKB: Protein Feature View | Search PDB | P27707  
     
  •   Structure Validation Hide

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  • MolProbity Ramachandran Plot
     

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  •   Source Hide
    Polymer: 1
    Scientific Name: Homo sapiens   Taxonomy   Common Name: Human Expression System: Escherichia coli  
     
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    Identifier Details
    4JLK   
     
  •   Ligand Chemical Component Hide
    Identifier Formula Name View Interactions
    1UX
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    1UX C22 H29 N5 O3 S2
    1-[5-(4-{[(4,6-diaminopyrimidin-2-yl)sulfanyl]methyl}- 5-propyl-1,3-thiazol-2-yl)-2-methoxyphenoxy]- 2-methylpropan-2-ol
    1UX:4L5B
    UDP
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    UDP C9 H14 N2 O12 P2
    URIDINE-5'-DIPHOSPHATE
    UDP:4L5B
     
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  •   Structural Biology Knowledgebase Data Hide
     
 
Data in orange boxes are gathered from external resources (when available).
 
  Biological Assembly       
Biological assembly 1 assigned by authors and generated by PISA (software)
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  •   Deposition Summary Hide
    Authors:   Nomme, J.,  Lavie, A.

    Deposition:   2013-06-10
    Release:   2013-09-18
    Last Modified (REVDAT):   2013-11-27
     
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    2013-11-27
    Citation
     
  •   Experimental Details Hide
    Method:   X-RAY DIFFRACTION
    Exp. Data:
      Structure Factors
    Resolution[Å]:   1.94
    R-Value: 0.190 (obs.)
    R-Free: 0.233
    Space Group: P 41
    Unit Cell:
      Length [Å] Angles [°]
    a = 68.67 α = 90.00 
    b = 68.67 β = 90.00 
    c = 120.02 γ = 90.00