4L4Q

Methionine Adenosyltransferase

PDB DOI: https://doi.org/10.2210/pdb4L4Q/pdb

Classification: TRANSFERASE
Organism(s): Thermococcus kodakarensis
Expression System: Escherichia coli
Mutation(s): No

Deposited: 2013-06-09 Released: 2014-03-19
Deposition Author(s): Schlesier, J., Siegrist, J., Gerhardt, S., Andexer, J.N., Einsle, O.

Experimental Data Snapshot

Method: X-RAY DIFFRACTION
Resolution: 2.00 Å
R-Value Free: 0.245
R-Value Work: 0.187
R-Value Observed: 0.190

wwPDB Validation 3D Report Full Report

This is version 1.1 of the entry. See complete history.

Literature

Structural and functional characterisation of the methionine adenosyltransferase from Thermococcus kodakarensis.

Schlesier, J., Siegrist, J., Gerhardt, S., Erb, A., Blaesi, S., Richter, M., Einsle, O., Andexer, J.N.

(2013) BMC Struct Biol 13: 22-22

PubMed: 24134203 Search on PubMedSearch on PubMed Central
DOI: https://doi.org/10.1186/1472-6807-13-22
Primary Citation of Related Structures:
4L4Q

PubMed Abstract:
Methionine adenosyltransferases catalyse the synthesis of S-adenosylmethionine, a cofactor abundant in all domains of life. In contrast to the enzymes from bacteria and eukarya that show high sequence similarity, methionine adenosyltransferases from archaea diverge on the amino acid sequence level and only few conserved residues are retained.

Organizational Affiliation

Institute of Pharmaceutical Sciences, Albert-Ludwigs-University Freiburg, Albertstr, 25, Freiburg D-79104, Germany. jennifer.andexer@pharmazie.uni-freiburg.de.

Macromolecule Content

Total Structure Weight: 178.69 kDa
Atom Count: 13,180
Modelled Residue Count: 1,607
Deposited Residue Count: 1,620
Unique protein chains: 1

Macromolecules

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(by identity cutoff) | 3D Structure

Entity ID: 1
Molecule	Chains	Sequence Length	Organism	Details	Image
S-adenosylmethionine synthase	A, B, C, D	405	Thermococcus kodakarensis	Mutation(s): 0 Gene Names: mat, metK, TK0545 EC: 2.5.1.6
UniProt
Find proteins for Q5JF22 (Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)) Explore Q5JF22 Go to UniProtKB: Q5JF22
Entity Groups
Sequence Clusters	30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity
UniProt Group	Q5JF22
Sequence Annotations Expand
Reference Sequence