The Crystal structure of PDE6D in complex with the inhibitor (s)-5
4JVF
Primary Citation
 
 
  •   Molecular Description Hide
    Classification: Protein Binding/inhibitor
    Structure Weight: 18224.11
    Molecule: Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
    Polymer: 1 Type: protein Length: 152
    Chains: B
    Organism: Homo sapiens
    Gene Names: Gene View for PDE6D PDED
    UniProtKB: Protein Feature View | Search PDB | O43924  
     
  •   Structure Validation Hide

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  • MolProbity Ramachandran Plot
     

  •   Related Citations in PDB Entry (REMARK 1) Hide
     
  •   Source Hide
    Polymer: 1
    Scientific Name: Homo sapiens   Taxonomy   Common Name: Human Expression System: Escherichia coli  
     
  •   Related PDB Entries Hide
    Identifier Details
    4JV6    
    4JV8    
    4JVB    
     
  •   Ligand Chemical Component Hide
    Identifier Formula Name View Interactions
    17X
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    17X C40 H42 N6 O2
    (2S)-2-(2-phenyl-1H-benzimidazol-1-yl)-2- (piperidin-4-yl)ethyl 1-(1-benzyl-1H-benzimidazol- 2-yl)piperidine-4-carboxylate
    17X:4JVF
     
  •   External Ligand Annotations Hide
    Identifier   Binding Affinity (Sequence Identity %)
    17X
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    17X
    N/Ain BindingDB
    Kd: 10 nM - data from BindingMOAD  
    N/Ain PDBbind
     
  •   External Domain Annotations Hide
     
  •   Structural Biology Knowledgebase Data Hide
     
 
Data in orange boxes are gathered from external resources (when available).
  Biological Assembly       
Biological assembly 1 assigned by authors and generated by PISA (software)
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