Download MendeleyNovel family of insect salivary inhibitors blocks contact pathway activation by binding to polyphosphate, heparin, and dextran sulfate.
Alvarenga, P.H., Xu, X., Oliveira, F., Chagas, A.C., Nascimento, C.R., Francischetti, I.M., Juliano, M.A., Juliano, L., Scharfstein, J., Valenzuela, J.G., Ribeiro, J.M., Andersen, J.F.(2013) Arterioscler Thromb Vasc Biol 33: 2759-2770
- PubMed: 24092749
- DOI: https://doi.org/10.1161/ATVBAHA.113.302482
- Primary Citation of Related Structures:
4JD9 - PubMed Abstract:
Polyphosphate and heparin are anionic polymers released by activated mast cells and platelets that are known to stimulate the contact pathway of coagulation. These polymers promote both the autoactivation of factor XII and the assembly of complexes containing factor XI, prekallikrein, and high-molecular-weight kininogen. We are searching for salivary proteins from blood-feeding insects that counteract the effect of procoagulant and proinflammatory factors in the host, including elements of the contact pathway.
Organizational Affiliation:
From the Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, Rockville, MD (P.H.A., X.X., F.O., A.C.C., I.M.B.F., J.G.V., J.M.C.R., J.F.A.); Laboratório de Bioquímica de Resposta ao Estresse, Instituto de Bioquímica Médica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil (P.H.A.); Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular (INCT-EM), Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil (P.H.A.); Instituto de Biofísica Carlos Chagas Filho, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil (C.R.N., J.S.); and Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil (M.A.J., L.J.).
