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The 1.9A crystal structure of humanized Xenopus Mdm2 with nutlin-3a
4J3E
Primary Citation
 
 
  •   Molecular Description Hide
    Classification: Ligase/antagonist
    Structure Weight: 10640.26
    Molecule: E3 ubiquitin-protein ligase Mdm2
    Polymer: 1 Type: protein Length: 86
    Chains: A
    EC#: 6.3.2   
    Fragment: N-terminal domain (UNP residues 21-105)
    Mutation: I50L, P92H, L95I
    Organism: Xenopus laevis
    Gene Name: mdm2
    UniProtKB: Protein Feature View | Search PDB | P56273  
     
  •   Structure Validation Hide

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  •   Source Hide
    Polymer: 1
    Scientific Name: Xenopus laevis   Taxonomy   Common Name: Clawed frog,common platanna,platanna Expression System: Escherichia coli  
     
  •   Related PDB Entries Hide
    Identifier Details
    1RV1  HUMAN MDM2 COMPLEXED WITH NUTLIN-2 
    4IPF  SAME PROTEIN COMPLEXED WITH RO5045337 
     
  •   Ligand Chemical Component Hide
    Identifier Formula Name View Interactions
    NUT
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    NUT C30 H30 Cl2 N4 O4
    4-({(4S,5R)-4,5-bis(4-chlorophenyl)-2-[4- methoxy-2-(propan-2-yloxy)phenyl]-4,5-dihydro- 1H-imidazol-1-yl}carbonyl)piperazin-2-one
    SO4
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    SO4 O4 S
    SULFATE ION
     
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  •   Structural Biology Knowledgebase Data Hide
     
 
Data in orange boxes are gathered from external resources (when available).
 
  Biological Assembly       
Biological assembly 1 assigned by authors and generated by PISA (software)
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  •   Deposition Summary Hide
    Authors:   Graves, B.J.,  Lukacs, C.M.,  Kammlott, R.U.,  Crowther, R.

    Deposition:   2013-02-05
    Release:   2013-04-24
    Last Modified (REVDAT):   2014-10-08
     
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    2014-10-08
    Citation
     
  •   Experimental Details Hide
    Method:   X-RAY DIFFRACTION
    Exp. Data:
      Structure Factors
    EDS  
    Resolution[Å]:   1.91
    R-Value: 0.196 (obs.)
    R-Free: 0.239
    Space Group: C 2 2 21
    Unit Cell:
      Length [Å] Angles [°]
    a = 42.89 α = 90.00 
    b = 67.66 β = 90.00 
    c = 67.17 γ = 90.00