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3-hydroxy-3-methylglutaryl (HMG) Coenzyme-A reductase complexed with thiomevalonate
4I6W
Primary Citation
 
 
  •   Molecular Description Hide
    Classification: Oxidoreductase
    Structure Weight: 92180.26
    Molecule: 3-hydroxy-3-methylglutaryl-coenzyme A reductase
    Polymer: 1 Type: protein Length: 428
    Chains: A, B
    EC#: 1.1.1.88   
    Organism: Pseudomonas mevalonii
    Gene Name: mvaA
    UniProtKB: Protein Feature View | Search PDB | P13702  
     
  •   Structure Validation Hide

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  • MolProbity Ramachandran Plot
     

  •   Related Citations in PDB Entry (REMARK 1) Hide
     
  •   Source Hide
    Polymer: 1
    Scientific Name: Pseudomonas mevalonii   Taxonomy   Expression System: Escherichia coli  
     
  •   Related PDB Entries Hide
    Identifier Details
    1QAX  same protein complexed with non-productive combination of ligands, NAD+ and HMG-CoA 
    4I4B  same protein complexed with reduced dithio-HMG-CoA intermediate and NAD+ 
    4I56  Same protein complexed with dithio-HMG-CoA 
    4I64  same protein high resolution native (apo) structure. 
    4I6A  Same protein complexed with HMG-CoA 
    4I6Y   
     
  •   Ligand Chemical Component Hide
    Identifier Formula Name View Interactions
    1CO
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    1CO C6 H12 O3 S
    (3S)-3-hydroxy-3-methyl-5-sulfanylpentanoic acid
    1CO:4I6W
    GOL
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    GOL C3 H8 O3
    GLYCEROL
    SO4
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    SO4 O4 S
    SULFATE ION
     
  •   External Domain Annotations Hide
     
  •   Structural Biology Knowledgebase Data Hide
     
 
Data in orange boxes are gathered from external resources (when available).
 
  Biological Assembly       
Biological assembly 1 assigned by authors and generated by PISA (software)
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