Download MendeleyPotent and selective inhibitors of USP7/HAUSP activity by protein conformational stabilization
Zhang, Y., Zhou, L., Rouge, L., Phillips, A.H., Lam, C., Liu, P., Sandoval, W., Helgason, E., Murray, J.M., Wertz, I., Corn, J.E.To be published.
4HK2
U7Ub25.2540
- PDB DOI: https://doi.org/10.2210/pdb4HK2/pdb
- Classification: SIGNALING PROTEIN/Inhibitor
- Organism(s): Homo sapiens
- Expression System: Escherichia coli BL21(DE3)
- Mutation(s): Yes
- Deposited: 2012-10-14 Released: 2012-11-21
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 1.40 Å
- R-Value Free: 0.236
- R-Value Work: 0.197
- R-Value Observed: 0.199
wwPDB Validation 3D Report Full Report
This is version 1.1 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Ubiquitin | 78 | Homo sapiens | Mutation(s): 7 Gene Names: UBC, Ubiquitin |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P0CG48 (Homo sapiens) Explore P0CG48 Go to UniProtKB: P0CG48 | |||||
PHAROS: P0CG48 GTEx: ENSG00000150991 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P0CG48 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 1 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| SO4 Query on SO4 | E [auth A] | SULFATE ION O4 S QAOWNCQODCNURD-UHFFFAOYSA-L |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 1.40 Å
- R-Value Free: 0.236
- R-Value Work: 0.197
- R-Value Observed: 0.199
- Space Group: P 31 2 1
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 85.782 | α = 90 |
| b = 85.782 | β = 90 |
| c = 54.457 | γ = 120 |
| Software Name | Purpose |
|---|---|
| SCALA | data scaling |
| PHASER | phasing |
| PHENIX | refinement |
| PDB_EXTRACT | data extraction |
| XSCALE | data scaling |
Entry History
Deposition Data
- Released Date: 2012-11-21 Deposition Author(s): Murray, J.M., Rouge, L.
Revision History (Full details and data files)
- Version 1.0: 2012-11-21
Type: Initial release - Version 1.1: 2023-09-20
Changes: Data collection, Database references, Derived calculations, Refinement description
