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Crystal structure of the catalytic domain of Human MMP12 in complex with a broad spectrum hydroxamate inhibitor
4H76
Primary Citation
 
 
  •   Molecular Description Hide
    Classification: Hydrolase/hydrolase Inhibitor
    Structure Weight: 18869.96
    Molecule: Macrophage metalloelastase
    Polymer: 1 Type: protein Length: 159
    Chains: A
    EC#: 3.4.24.65   
    Fragment: Human MMP12 catalytic domain: unp residues 106-263
    Mutation: F171D
    Organism: Homo sapiens
    Gene Names: Gene View for MMP12 HME
    UniProtKB: Protein Feature View | Search PDB | P39900  
     
  •   Structure Validation Hide

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  • MolProbity Ramachandran Plot
     

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  •   Source Hide
    Polymer: 1
    Scientific Name: Homo sapiens   Taxonomy   Common Name: Human Expression System: Escherichia coli  
     
  •   Related PDB Entries Hide
    Identifier Details
    1RMZ  Crystal structure of the catalytic domain of human MMP12 complexed with the inhibitor NNGH at 1.3 A resolution 
    3LIK  Human MMP12 in complex with non-zinc chelating inhibitor 
    3LIL  Human MMP12 in complex with non-zinc chelating inhibitor 
    3LJG  Human MMP12 in complex with non-zinc chelating inhibitor 
    3TS4  Human MMP12 in complex with L-glutamate motif inhibitor 
    3TSK  Human MMP12 in complex with L-glutamate motif inhibitor 
    4EFS  Human MMP12 in complex with L-glutamate motif inhibitor 
    4GQL  Crystal structure of the catalytic domain of Human MMP12 in complex with selective phosphinic inhibitor RXP470.1 
    4GR0  Crystal structure of the catalytic domain of Human MMP12 in complex with selective phosphinic inhibitor RXP470B 
    4H30  CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF MMP-12 IN COMPLEX WITH A TWIN INHIBITOR. 
    4H3X  Crystal structure of an MMP broad spectrum hydroxamate based inhibitor CC27 in complex with the MMP-9 catalytic domain 
     
  •   Ligand Chemical Component Hide
    Identifier Formula Name View Interactions
    10B
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    10B C17 H20 N2 O5 S
    N-2-(biphenyl-4-ylsulfonyl)-N-2-(isopropyloxy)- acetohydroxamic acid
    10B:4H76
    CA
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    CA Ca
    CALCIUM ION
    GOL
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    GOL C3 H8 O3
    GLYCEROL
    PEG
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    PEG C4 H10 O3
    DI(HYDROXYETHYL)ETHER
    PGO
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    PGO C3 H8 O2
    S-1,2-PROPANEDIOL
    PGO:4H76
    ZN
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    ZN Zn
    ZINC ION
     
  •   External Domain Annotations Hide
     
  •   Structural Biology Knowledgebase Data Hide
     
 
Data in orange boxes are gathered from external resources (when available).
 
  Biological Assembly       
Biological assembly 1 assigned by authors and generated by PISA (software)
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