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Crystal structure of mutant MMP-9 catalytic domain in complex with a twin inhibitor.
4H1Q
Primary Citation
 
 
  •   Molecular Description Hide
    Classification: Hydrolase/hydrolase Inhibitor
    Structure Weight: 38638.64
    Molecule: Matrix metalloproteinase-9
    Polymer: 1 Type: protein Length: 160
    Chains: A, B
    EC#: 3.4.24.35   
    Fragment: unp residues 110-214
    Mutation: E402Q
    Organism: Homo sapiens
    Gene Names: Gene View for MMP9 CLG4B
    UniProtKB: Protein Feature View | Search PDB | P14780  
     
  •   Structure Validation Hide

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  •   Source Hide
    Polymer: 1
    Scientific Name: Homo sapiens   Taxonomy   Common Name: Human Expression System: Escherichia coli  
     
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    Identifier Details
    2OW1  MMP-9 active site mutant with trifluoromethyl hydroxamate inhibitor 
    4H2E   
    4H30   
    4H3X   
     
  •   Ligand Chemical Component Hide
    Identifier Formula Name View Interactions
    0XX
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    0XX C54 H66 N8 O14 S2
    N-(4-{[(3R)-3-[(biphenyl-4-ylsulfonyl)(propan- 2-yloxy)amino]-4-(hydroxyamino)-4-oxobutyl]amino}- 4-oxobutyl)-N'-(4-{[(3S)-3-[(biphenyl-4-ylsulfonyl)(propan- 2-yloxy)amino]-4-(hydroxyamino)-4-oxobutyl]amino}- 4-oxobutyl)benzene-1,3-dicarboxamide
    0XX:4H1Q
    CA
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    CA Ca
    CALCIUM ION
    ZN
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    ZN Zn
    ZINC ION
     
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  •   Structural Biology Knowledgebase Data Hide
     
 
Data in orange boxes are gathered from external resources (when available).
 
  Biological Assembly 1       
Biological assembly 1 assigned by authors and generated by PISA (software)
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