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Human topoisomerase iibeta in complex with DNA and ametantrone
DOI:10.2210/pdb4g0w/pdb   NDB ID: NA1935
4G0W
Primary Citation
 
 
  •   Molecular Description Hide
    Classification: Isomerase/dna/isomerase Inhibitor
    Structure Weight: 197011.31
    Molecule: DNA topoisomerase 2-beta
    Polymer: 1 Type: protein Length: 803
    Chains: A, B
    EC#: 5.99.1.3   
    Fragment: HTOP2BETA CLEAVAGE CORE, UNP RESIDUES 450-1206
    Organism: Homo sapiens
    Gene Name: Gene View for TOP2B
    UniProtKB: Protein Feature View | Search PDB | Q02880  
    Molecule: DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3')
    Polymer: 2 Type: dna Length: 8
    Chains: C, E
    Molecule: DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3')
    Polymer: 3 Type: dna Length: 12
    Chains: D, F
     
  •   Structure Validation Hide

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  • MolProbity Ramachandran Plot
     

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  •   Source Hide
    Polymer: 1
    Scientific Name: Homo sapiens   Taxonomy   Common Name: Human Expression System: Escherichia coli  
    Polymer: 2
    Scientific Name: Synthetic construct   Taxonomy    
    Polymer: 3
    Scientific Name: Synthetic construct   Taxonomy    
     
  •   Related PDB Entries Hide
    Identifier Details
    3QX3  Human topoisomerase IIbeta in complex with DNA and etoposide 
    4G0U   
    4G0V   
    4J3N   
     
  •   Ligand Chemical Component Hide
    Identifier Formula Name View Interactions
    AKE
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    AKE C22 H28 N4 O4
    1,4-bis({2-[(2-hydroxyethyl)amino]ethyl}amino)anthracene- 9,10-dione
    AKE:4G0W
    MG
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    MG Mg
    MAGNESIUM ION
     
  •   External Domain Annotations Hide
     
  •   Structural Biology Knowledgebase Data Hide
     
  • Nucleic Acid Database Hide
    View the NDB ID associated with this structure: NA1935
     
 
Data in orange boxes are gathered from external resources (when available).
 
  Biological Assembly       
Biological assembly 1 assigned by authors and generated by PISA (software)
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  •   Deposition Summary Hide
    Authors:   Wu, C.C.,  Li, T.K.,  Li, Y.C.,  Chan, N.L.

    Deposition:   2012-07-10
    Release:   2013-07-17
    Last Modified (REVDAT):   2014-03-12
     
  •   Revision History    Hide
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    2014-03-12
    Citation
    2013-10-02
    Citation
     
  •   Experimental Details Hide
    Method:   X-RAY DIFFRACTION
    Exp. Data:
      Structure Factors
    EDS  
    Resolution[Å]:   2.70
    R-Value: 0.168 (obs.)
    R-Free: 0.215
    Space Group: P 21
    Unit Cell:
      Length [Å] Angles [°]
    a = 80.66 α = 90.00 
    b = 176.42 β = 112.04 
    c = 93.64 γ = 90.00