Download MendeleyStructure of a high affinity TCR reveals native binding to MHC with enhanced peptide specificity
Borbulevych, O.Y., Baker, B.M.To be published.
4FTV
The complex between the high affinity version of A6 TCR (A6c134) and human Class I MHC HLA-A2 with the bound TAX nonameric peptide
- PDB DOI: https://doi.org/10.2210/pdb4FTV/pdb
- Classification: IMMUNE SYSTEM
- Organism(s): Homo sapiens, Human T-cell lymphotropic virus type 1 (african isolate)
- Expression System: Escherichia coli BL21
- Mutation(s): No
- Deposited: 2012-06-28 Released: 2013-07-03
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 2.74 Å
- R-Value Free: 0.260
- R-Value Work: 0.216
- R-Value Observed: 0.218
wwPDB Validation 3D Report Full Report
This is version 1.0 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| HLA class I histocompatibility antigen, A-2 alpha chain | 275 | Homo sapiens | Mutation(s): 0 Gene Names: HLA-A, HLAA |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P04439 (Homo sapiens) Explore P04439 Go to UniProtKB: P04439 | |||||
PHAROS: P04439 GTEx: ENSG00000206503 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P04439 | ||||
Sequence AnnotationsExpand | |||||
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Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 2 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Beta-2-microglobulin | 100 | Homo sapiens | Mutation(s): 0 Gene Names: B2M, CDABP0092, HDCMA22P |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P61769 (Homo sapiens) Explore P61769 Go to UniProtKB: P61769 | |||||
PHAROS: P61769 GTEx: ENSG00000166710 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P61769 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Find similar proteins by: Sequence | 3D Structure
Entity ID: 3 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Protein Tax-1 | 9 | Human T-cell lymphotropic virus type 1 (african isolate) | Mutation(s): 0 |  | |
UniProt | |||||
Find proteins for P0C213 (Human T-cell leukemia virus 1 (isolate Zaire EL subtype B)) Explore P0C213 Go to UniProtKB: P0C213 | |||||
Entity Groups | |||||
| UniProt Group | P0C213 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 4 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| A6 alpha chain | 200 | Homo sapiens | Mutation(s): 0 |  | |
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
Sequence AnnotationsExpand | |||||
| |||||
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 5 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| A6 beta chain | 245 | Homo sapiens | Mutation(s): 0 |  | |
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
Sequence AnnotationsExpand | |||||
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Small Molecules
| Ligands 1 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| GOL Query on GOL | F [auth A] G [auth A] H [auth A] I [auth A] J [auth A] | GLYCEROL C3 H8 O3 PEDCQBHIVMGVHV-UHFFFAOYSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 2.74 Å
- R-Value Free: 0.260
- R-Value Work: 0.216
- R-Value Observed: 0.218
- Space Group: C 1 2 1
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 224.23 | α = 90 |
| b = 48.954 | β = 89.62 |
| c = 94.398 | γ = 90 |
| Software Name | Purpose |
|---|---|
| SCALEPACK | data scaling |
| REFMAC | refinement |
| PDB_EXTRACT | data extraction |
| HKL-2000 | data collection |
| HKL-2000 | data reduction |
| HKL-2000 | data scaling |
| MOLREP | phasing |
Entry History
Deposition Data
- Released Date: 2013-07-03 Deposition Author(s): Borbulevych, O.Y., Baker, B.M.
Revision History (Full details and data files)
- Version 1.0: 2013-07-03
Type: Initial release
