Download MendeleyPairwise interaction of alpha-conotoxin BuIA Pro6 with the beta subunit of nicotinic acetylcholine receptor
Filchakova, O.M., Talley, T.T., Reger, A.S., Kim, C., Ho, K., Han, K., Taylor, P., McIntosh, J.M.To be published.
4EZ1
Crystal structure of acetylcholine binding protein (AChBP) from Aplysia Californica in complex with alpha-conotoxin BuIA
- PDB DOI: https://doi.org/10.2210/pdb4EZ1/pdb
- Classification: CHOLINE BINDING PROTEIN/TOXIN
- Organism(s): Aplysia californica, Conus bullatus
- Expression System: Homo sapiens
- Mutation(s): No
- Deposited: 2012-05-02 Released: 2013-05-08
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 2.49 Å
- R-Value Free: 0.227
- R-Value Work: 0.171
- R-Value Observed: 0.174
wwPDB Validation 3D Report Full Report
This is version 1.1 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Soluble acetylcholine receptor | 230 | Aplysia californica | Mutation(s): 0 |  | |
UniProt | |||||
Find proteins for Q8WSF8 (Aplysia californica) Explore Q8WSF8 Go to UniProtKB: Q8WSF8 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | Q8WSF8 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Find similar proteins by: Sequence | 3D Structure
Entity ID: 2 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Alpha-conotoxin BuIA | F [auth K], G [auth L], H [auth M], I [auth N], J [auth O] | 14 | Conus bullatus | Mutation(s): 0 |  |
UniProt | |||||
Find proteins for P69657 (Conus bullatus) Explore P69657 Go to UniProtKB: P69657 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P69657 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 1 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| MN Query on MN | K [auth C] | MANGANESE (II) ION Mn WAEMQWOKJMHJLA-UHFFFAOYSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 2.49 Å
- R-Value Free: 0.227
- R-Value Work: 0.171
- R-Value Observed: 0.174
- Space Group: P 1 21 1
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 68.437 | α = 90 |
| b = 78.636 | β = 93.2 |
| c = 117.636 | γ = 90 |
| Software Name | Purpose |
|---|---|
| BOS | data collection |
| PHASER | phasing |
| REFMAC | refinement |
| HKL-2000 | data reduction |
| HKL-2000 | data scaling |
Entry History
Deposition Data
- Released Date: 2013-05-08 Deposition Author(s): Talley, T.T., Reger, A.S., Kim, C., Sankaran, B., Ho, K., Taylor, P., McIntosh, J.M.
Revision History (Full details and data files)
- Version 1.0: 2013-05-08
Type: Initial release - Version 1.1: 2013-06-19
Changes: Structure summary
